Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down‐regulation

Objectives  Acteoside is a phenylpropanoid glycoside extracted from the leaves of Rehmannia glutinosa that displays various biological activities. In this study, we tested the effects of acteoside on tyrosinase activity and melanin biosynthesis in B16F10 melanoma cells. We also explored molecular mechanisms for the inhibition of melanogenesis observed, focusing on the signalling pathway of extracellular signal‐regulated kinase (ERK).

[1]  R. Reid,et al.  Evaluation of quality control strategies in Scutellaria herbal medicines. , 2011, Journal of pharmaceutical and biomedical analysis.

[2]  Y. M. Lee,et al.  Inhibitory effect of glyceollin isolated from soybean against melanogenesis in B16 melanoma cells. , 2010, BMB reports.

[3]  Jongsung Lee,et al.  Mechanisms of melanogenesis inhibition by propafenone , 2010, Archives of Dermatological Research.

[4]  Lei Guo,et al.  Baicalein inhibits melanogenesis through activation of the ERK signaling pathway. , 2010, International journal of molecular medicine.

[5]  Tzung-Han Chou,et al.  Antioxidative characteristics and inhibition of α‐melanocyte‐stimulating hormone‐stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare , 2009, Experimental dermatology.

[6]  Yu-Chih Liang,et al.  Acteoside and 6-O-acetylacteoside downregulate cell adhesion molecules induced by IL-1beta through inhibition of ERK and JNK in human vascular endothelial cells. , 2009, Journal of agricultural and food chemistry.

[7]  H. Song,et al.  Acetoside inhibits α‐MSH‐induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase , 2009 .

[8]  Jimin Xu,et al.  2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG) induces melanogenesis in B16 cells by MAP kinase activation and tyrosinase upregulation. , 2009, Life sciences.

[9]  Te-Sheng Chang,et al.  An Updated Review of Tyrosinase Inhibitors , 2009, International journal of molecular sciences.

[10]  V. Hearing,et al.  Physiological factors that regulate skin pigmentation , 2009, BioFactors.

[11]  H. Song,et al.  Acteoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase. , 2009, The Journal of pharmacy and pharmacology.

[12]  K. Wakamatsu,et al.  Chemistry of Mixed Melanogenesis—Pivotal Roles of Dopaquinone † , 2008, Photochemistry and photobiology.

[13]  N. Sadick,et al.  The use of antisense strategy to modulate human melanogenesis. , 2007, Journal of drugs in dermatology : JDD.

[14]  Dong-Nyung Lee,et al.  Effects of ephedrae herba on melanogenesis and gene expression profiles using cDNA microarray in B16 melanocytes , 2006, Phytotherapy research : PTR.

[15]  Y. Ohkawa,et al.  The Microphthalmia-associated Transcription Factor Requires SWI/SNF Enzymes to Activate Melanocyte-specific Genes* , 2006, Journal of Biological Chemistry.

[16]  Jeong Ah Kim,et al.  Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression. , 2006, Pigment cell research.

[17]  Jeong-Chae Lee,et al.  Antioxidant property of an active component purified from the leaves of paraquat-tolerant Rehmannia glutinosa , 2005, Redox report : communications in free radical research.

[18]  V. Hearing.  Biogenesis of pigment granules: a sensitive way to regulate melanocyte function. , 2005, Journal of dermatological science.

[19]  Kyoung-Chan Park,et al.  Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation , 2003, Journal of Cell Science.

[20]  Kazuhiro Takahashi,et al.  Identification of a distal enhancer for the melanocyte-specific promoter of the MITF gene. , 2002, Pigment cell research.

[21]  I. Hwang,et al.  Acteoside from Rehmannia glutinosa nullifies paraquat activity in Cucumis sativus , 2002 .

[22]  Toshio Mori,et al.  Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes. , 2001, Pigment cell research.

[23]  E. Sharlow,et al.  Inhibition of melanosome transfer results in skin lightening. , 2000, The Journal of investigative dermatology.

[24]  R. Buscà,et al.  Cyclic AMP a key messenger in the regulation of skin pigmentation. , 2000, Pigment cell research.

[25]  M. Nukina,et al.  Radical scavenging activity of phenylpropanoid glycosides in Caryopteris incana. , 1999, Bioscience, biotechnology, and biochemistry.

[26]  E. Price,et al.  α-Melanocyte-stimulating Hormone Signaling Regulates Expression of microphthalmia, a Gene Deficient in Waardenburg Syndrome* , 1998, The Journal of Biological Chemistry.

[27]  K. Hase,et al.  Hepatoprotective activity of phenylethanoids from Cistanche deserticola. , 1998, Planta medica.

[28]  A. Henriques,et al.  Antiinflammatory and antinociceptive activities of extracts and isolated compounds from Stachytarpheta cayennensis. , 1998, Journal of ethnopharmacology.

[29]  J. Park,et al.  Biological role of tyrosinase related protein and its biosynthesis and transport from TGN to stage I melanosome, late endosome, through gene transfection study. , 1997, Pigment cell research.

[30]  M. Tachibana,et al.  Evidence to suggest that expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg syndrome type 2A. , 1997, Pigment cell research.

[31]  E. Medrano,et al.  Retroviral infection with human tyrosinase-related protein-1 (TRP-1) cDNA upregulates tyrosinase activity and melanin synthesis in a TRP-1-deficient melanoma cell line. , 1996, The Journal of investigative dermatology.

[32]  M. Iinuma,et al.  Studies of cuticle drugs from natural sources. IV. Inhibitory effects of some Arctostaphylos plants on melanin biosynthesis. , 1996, Biological & pharmaceutical bulletin.

[33]  J. Ortonne,et al.  Mitogen-activated Protein Kinase Pathway and AP-1 Are Activated during cAMP-induced Melanogenesis in B-16 Melanoma Cells (*) , 1995, The Journal of Biological Chemistry.

[34]  K. Jimbow,et al.  Current update and trends in melanin pigmentation and melanin biology. , 1995, The Keio journal of medicine.

[35]  C. Goding,et al.  Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator , 1994, Molecular and cellular biology.

[36]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.