Structure of potassium channels

[1]  G. F. Ruda,et al.  K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac , 2015, Science.

[2]  P. Koeck,et al.  Free RCK arrangement in Kch, a putative escherichia coli potassium channel, as suggested by electron crystallography. , 2015, Structure.

[3]  D. Minor,et al.  Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels , 2014, Neuron.

[4]  Ernest B. Campbell,et al.  Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel , 2014, Nature.

[5]  Jiusheng Yan,et al.  Regulation of BK channels by auxiliary γ subunits , 2014, Front. Physiol..

[6]  Terrence Frey,et al.  Faculty Opinions recommendation of TRPV1 structures in distinct conformations reveal activation mechanisms. , 2014 .

[7]  P. Purhonen,et al.  The projection structure of Kch, a putative potassium channel in Escherichia coli, by electron crystallography. , 2014, Biochimica et biophysica acta.

[8]  D. Julius,et al.  Structure of the TRPV1 ion channel determined by electron cryo-microscopy , 2013, Nature.

[9]  M. Sansom,et al.  Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains , 2013, The Journal of Biological Chemistry.

[10]  G. Cingolani,et al.  Structural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domain , 2013, Nature Communications.

[11]  R. MacKinnon,et al.  X-ray structure of the mammalian GIRK2-beta gamma G-protein complex. , 2013 .

[12]  R. MacKinnon,et al.  X-ray structure of the mammalian GIRK2 – βγ G protein complex , 2013, Nature.

[13]  Xiangshu Jin,et al.  Gating of the TrkH Ion Channel by its Associated RCK Protein, Trka , 2013, Nature.

[14]  E. Campbell,et al.  Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel , 2013, Proceedings of the National Academy of Sciences.

[15]  William A. Catterall,et al.  Crystal structure of a voltage-gated sodium channel in two potentially inactivated states , 2012, Nature.

[16]  Jianhua He,et al.  Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel , 2012, Nature.

[17]  Björn Wallner,et al.  Tracking a complete voltage-sensor cycle with metal-ion bridges , 2012, Proceedings of the National Academy of Sciences.

[18]  Simone Furini,et al.  Molecular dynamics simulations of the TrkH membrane protein. , 2012, Biochemistry.

[19]  J. McCoy,et al.  Structural correlates of selectivity and inactivation in potassium channels. , 2012, Biochimica et biophysica acta.

[20]  R. MacKinnon,et al.  Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel , 2012, Science.

[21]  S. Long,et al.  Crystal Structure of the Human Two–Pore Domain Potassium Channel K2P1 , 2012, Science.

[22]  R. MacKinnon,et al.  Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel , 2011, Nature.

[23]  C. Venien-Bryan,et al.  Structure of a KirBac potassium channel with an open bundle-crossing indicates a mechanism of channel gating , 2011, Nature Structural &Molecular Biology.

[24]  Zhong-ju Xiao,et al.  Electrostatic interaction between inactivation ball and T1-S1 linker region of Kv1.4 channel. , 2012, Biochimica et biophysica acta.

[25]  David Baker,et al.  Structural basis for gating charge movement in the voltage sensor of a sodium channel , 2011, Proceedings of the National Academy of Sciences.

[26]  P. Hart,et al.  Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain , 2011, Proceedings of the National Academy of Sciences.

[27]  Roderick MacKinnon,et al.  Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium , 2011, Cell.

[28]  Xiao Tao,et al.  Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2 , 2011, Nature.

[29]  M. Raja Diverse gating in K+ channels: differential role of the pore-helix glutamate in stabilizing the channel pore. , 2011, Biochemical and biophysical research communications.

[30]  Markus Rapedius,et al.  The pore structure and gating mechanism of K2P channels , 2011, The EMBO journal.

[31]  W. Catterall,et al.  THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL , 2011, Nature.

[32]  Simone Furini,et al.  Selectivity and permeation of alkali metal ions in K+-channels. , 2011, Journal of molecular biology.

[33]  Youxing Jiang,et al.  Structural studies of ion selectivity in tetrameric cation channels , 2011, The Journal of general physiology.

[34]  Weiran Liu,et al.  Lipid-dependent gating of a voltage-gated potassium channel , 2011, Nature communications.

[35]  C. Nichols,et al.  Mechanism for selectivity-inactivation coupling in KcsA potassium channels , 2011, Proceedings of the National Academy of Sciences.

[36]  Stefan A. Mann,et al.  Mapping the sequence of conformational changes underlying selectivity filter gating in the Kv11.1 potassium channel , 2011, Nature Structural &Molecular Biology.

[37]  D. Sauer,et al.  Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites , 2010, Proceedings of the National Academy of Sciences.

[38]  William A. Catterall,et al.  Signaling complexes of voltage-gated sodium and calcium channels , 2010, Neuroscience Letters.

[39]  J. Morais-Cabral,et al.  310 helices in channels and other membrane proteins , 2010, The Journal of general physiology.

[40]  J. Encinar,et al.  Ion binding to KcsA: implications in ion selectivity and channel gating. , 2010, Biochemistry.

[41]  Roderick MacKinnon,et al.  Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP. , 2010, Journal of molecular biology.

[42]  I. Booth,et al.  Mechanism of ligand-gated potassium efflux in bacterial pathogens , 2010, Proceedings of the National Academy of Sciences.

[43]  A. Nakagawa,et al.  A Structural Determinant for the Control of PIP2 Sensitivity in G Protein-gated Inward Rectifier K+ Channels , 2010, The Journal of Biological Chemistry.

[44]  William A Catterall,et al.  Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology , 2010, Neuron.

[45]  Zhe Lu,et al.  A Shaker K+ Channel with a Miniature Engineered Voltage Sensor , 2010, Cell.

[46]  Yang Li,et al.  Novel insights into K+ selectivity from high resolution structures of an open K+ channel pore , 2010, Nature Structural &Molecular Biology.

[47]  Roderick MacKinnon,et al.  Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 Å Resolution , 2010, Science.

[48]  Eduardo Perozo,et al.  Structural mechanism of C-type inactivation in K+ channels , 2010, Nature.

[49]  Benoît Roux,et al.  Structural basis for the coupling between activation and inactivation gates in K+ channels , 2010, Nature.

[50]  Yunkun Wu,et al.  Structure of the Gating Ring from the Human High-conductance Ca2+-gated K+ Channel , 2010, Nature.

[51]  Brian J. Smith,et al.  Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels , 2010, Cell.

[52]  Jianpeng Ma,et al.  Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement , 2010, Proceedings of the National Academy of Sciences.

[53]  C. Nichols,et al.  Lipids driving protein structure? Evolutionary adaptations in Kir channels , 2010, Channels.

[54]  Xiao Tao,et al.  A Gating Charge Transfer Center in Voltage Sensors , 2010, Science.

[55]  Péter Enyedi,et al.  Molecular Background of Leak K (cid:1) Currents: Two-Pore Domain Potassium Channels , 2010 .

[56]  O. Pongs,et al.  Ancillary subunits associated with voltage-dependent K+ channels. , 2010, Physiological reviews.

[57]  Kresten Lindorff-Larsen,et al.  Principles of conduction and hydrophobic gating in K+ channels , 2010, Proceedings of the National Academy of Sciences.

[58]  I. Shimada,et al.  Structural basis underlying the dual gate properties of KcsA , 2010, Proceedings of the National Academy of Sciences.

[59]  X. Tao Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 Angstrom resolution , 2010 .

[60]  Kazuharu Furutani,et al.  Inwardly rectifying potassium channels: their structure, function, and physiological roles. , 2010, Physiological reviews.

[61]  R. MacKinnon,et al.  Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution , 2009, Science.

[62]  Ilsoo Kim,et al.  Mechanism of potassium-channel selectivity revealed by Na+ and Li+ binding sites within the KcsA pore , 2009, Nature Structural &Molecular Biology.

[63]  Zhe Lu,et al.  Physical determinants of strong voltage sensitivity of K+ channel block , 2009, Nature Structural &Molecular Biology.

[64]  A. Engel,et al.  Assembly of Kch, a putative potassium channel from Escherichia coli. , 2009, Journal of structural biology.

[65]  S. Furini,et al.  Atypical mechanism of conduction in potassium channels , 2009, Proceedings of the National Academy of Sciences.

[66]  O. Pongs,et al.  Coupling of activation and inactivation gate in a K+‐channel: potassium and ligand sensitivity , 2009, The EMBO journal.

[67]  Fred J. Sigworth,et al.  Cryo-EM structure of the BK potassium channel in a lipid membrane , 2009, Nature.

[68]  S. Choe,et al.  KTN (RCK) Domains Regulate K+ Channels and Transporters by Controlling the Dimer-Hinge Conformation , 2009, Structure.

[69]  Seok-Yong Lee,et al.  Two Separate Interfaces between the Voltage Sensor and Pore Are Required for the Function of Voltage-Dependent K+ Channels , 2009, PLoS biology.

[70]  John M. Walker,et al.  Potassium Channels , 2009, Methods in Molecular Biology.

[71]  Yuval Ben-Abu,et al.  Inverse coupling in leak and voltage-activated K+ channel gates underlies distinct roles in electrical signaling , 2009, Nature Structural &Molecular Biology.

[72]  K. Swartz,et al.  Sensing voltage across lipid membranes , 2008, Nature.

[73]  P. Selvin,et al.  Extent of Voltage Sensor Movement during Gating of Shaker K+ Channels , 2008, Neuron.

[74]  Bertil Hille,et al.  PIP2 is a necessary cofactor for ion channel function: how and why? , 2008, Annual review of biophysics.

[75]  Hywel Morgan,et al.  Binding of anionic lipids to at least three nonannular sites on the potassium channel KcsA is required for channel opening. , 2008, Biophysical journal.

[76]  K. Sharp,et al.  The role of conformation in ion permeation in a K+ channel. , 2008, Journal of the American Chemical Society.

[77]  J. Morais-Cabral,et al.  Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel , 2008, Proceedings of the National Academy of Sciences.

[78]  S. Furini,et al.  Role of the intracellular cavity in potassium channel conductivity. , 2007, The journal of physical chemistry. B.

[79]  E. Campbell,et al.  Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment , 2007, Nature.

[80]  A. A. Alabi,et al.  Portability of paddle motif function and pharmacology in voltage sensors , 2007, Nature.

[81]  Benoît Roux,et al.  Closing In on the Resting State of the Shaker K+ Channel , 2007, Neuron.

[82]  M. Cadene,et al.  Crystal structure of a Kir3.1‐prokaryotic Kir channel chimera , 2007, The EMBO journal.

[83]  B. Bean The action potential in mammalian central neurons , 2007, Nature Reviews Neuroscience.

[84]  Ming Zhou,et al.  Structural and Thermodynamic Properties of Selective Ion Binding in a K+ Channel , 2007, PLoS biology.

[85]  R. MacKinnon,et al.  Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation , 2006, Science.

[86]  J. Bischofberger,et al.  BKCa-Cav Channel Complexes Mediate Rapid and Localized Ca2+-Activated K+ Signaling , 2006, Science.

[87]  Ehud Y Isacoff,et al.  How does voltage open an ion channel? , 2006, Annual review of cell and developmental biology.

[88]  Chae Un Kim,et al.  The RCK Domain of the KtrAB K+ Transporter: Multiple Conformations of an Octameric Ring , 2006, Cell.

[89]  Youxing Jiang,et al.  Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K+ Channels , 2006, Cell.

[90]  A. Lundby,et al.  Molecular Template for a Voltage Sensor in a Novel K+ Channel. I. Identification and Functional Characterization of KvLm, a Voltage-gated K+ Channel from Listeria monocytogenes , 2006, The Journal of general physiology.

[91]  A. Lundby,et al.  Molecular Template for a Voltage Sensor in a Novel K+ Channel. II. Conservation of a Eukaryotic Sensor Fold in a Prokaryotic K+ Channel , 2006, The Journal of general physiology.

[92]  Yasushi Okamura,et al.  A Voltage Sensor-Domain Protein Is a Voltage-Gated Proton Channel , 2006, Science.

[93]  David E. Clapham,et al.  A voltage-gated proton-selective channel lacking the pore domain , 2006, Nature.

[94]  Benoît Roux,et al.  Molecular determinants of gating at the potassium-channel selectivity filter , 2006, Nature Structural &Molecular Biology.

[95]  C. Kung,et al.  Prokaryotic K(+) channels: from crystal structures to diversity. , 2005, FEMS microbiology reviews.

[96]  Seok-Yong Lee,et al.  Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[97]  Manoj N. Krishnan,et al.  Functional Role and Affinity of Inorganic Cations in Stabilizing the Tetrameric Structure of the KcsA K+ Channel , 2005, The Journal of general physiology.

[98]  E. Campbell,et al.  Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling , 2005, Science.

[99]  E. Campbell,et al.  Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel , 2005, Science.

[100]  W. Catterall,et al.  Ion Permeation through a Voltage- Sensitive Gating Pore in Brain Sodium Channels Having Voltage Sensor Mutations , 2005, Neuron.

[101]  S. Buckingham,et al.  Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms. , 2005, Trends in pharmacological sciences.

[102]  Yasushi Okamura,et al.  Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor , 2005, Nature.

[103]  S. Korn,et al.  Potassium channels , 2005, IEEE Transactions on NanoBioscience.

[104]  Wei Zhou,et al.  Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification , 2005, Nature Neuroscience.

[105]  E. Isacoff,et al.  Voltage-Sensing Arginines in a Potassium Channel Permeate and Occlude Cation-Selective Pores , 2005, Neuron.

[106]  C. Ptak,et al.  Electrostatic interaction of a K+ channel RCK domain with charged membrane surfaces. , 2005, Biochemistry.

[107]  W. Catterall,et al.  Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[108]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[109]  Ming Zhou,et al.  A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. , 2004, Journal of molecular biology.

[110]  F. Bezanilla,et al.  A proton pore in a potassium channel voltage sensor reveals a focused electric field , 2004, Nature.

[111]  R. MacKinnon,et al.  The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. , 2003, Journal of molecular biology.

[112]  C. Zeilinger,et al.  MjK1, a K+ channel from M. jannaschii, mediates K+ uptake and K+ sensitivity in E. coli , 2003, FEBS letters.

[113]  F. Ashcroft,et al.  Crystal Structure of the Potassium Channel KirBac1.1 in the Closed State , 2003, Science.

[114]  F. Reimann,et al.  Sulphonylurea action revisited: the post-cloning era , 2003, Diabetologia.

[115]  Youxing Jiang,et al.  The principle of gating charge movement in a voltage-dependent K+ channel , 2003, Nature.

[116]  M. Cadene,et al.  X-ray structure of a voltage-dependent K+ channel , 2003, Nature.

[117]  F. Sesti,et al.  Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel , 2003, Nature Neuroscience.

[118]  J. Tate,et al.  Potassium channels: structures, models, simulations. , 2002, Biochimica et biophysica acta.

[119]  G. Yellen The voltage-gated potassium channels and their relatives , 2002, Nature.

[120]  R. MacKinnon,et al.  Lipids in the structure, folding, and function of the KcsA K+ channel. , 2002, Biochemistry.

[121]  Ian R. Booth,et al.  A Mechanism of Regulating Transmembrane Potassium Flux through a Ligand-Mediated Conformational Switch , 2002, Cell.

[122]  Youxing Jiang,et al.  Crystal structure and mechanism of a calcium-gated potassium channel , 2002, Nature.

[123]  Youxing Jiang,et al.  The open pore conformation of potassium channels , 2002, Nature.

[124]  M. Lazdunski,et al.  Polyunsaturated fatty acids induce ischemic and epileptic tolerance , 2002, Neuroscience.

[125]  R. MacKinnon,et al.  Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution , 2001, Nature.

[126]  Roderick MacKinnon,et al.  Energetic optimization of ion conduction rate by the K+ selectivity filter , 2001, Nature.

[127]  Zhe Lu,et al.  Ion conduction pore is conserved among potassium channels , 2001, Nature.

[128]  R. MacKinnon,et al.  Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors , 2001, Nature.

[129]  Francisco Bezanilla,et al.  Histidine Scanning Mutagenesis of Basic Residues of the S4 Segment of the Shaker K+ Channel , 2001, The Journal of general physiology.

[130]  Youxing Jiang,et al.  Structure of the RCK Domain from the E. coli K+ Channel and Demonstration of Its Presence in the Human BK Channel , 2001, Neuron.

[131]  R. MacKinnon,et al.  The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations. , 1999, Science.

[132]  M. Lazdunski,et al.  A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids , 1998, The EMBO journal.

[133]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[134]  Bertil Hille,et al.  Voltage-Gated Ion Channels and Electrical Excitability , 1998, Neuron.

[135]  Roderick MacKinnon,et al.  Contribution of the S4 Segment to Gating Charge in the Shaker K+ Channel , 1996, Neuron.

[136]  T Hoshi,et al.  Biophysical and molecular mechanisms of Shaker potassium channel inactivation , 1990, Science.

[137]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.