The strong relationship between disease severity and thiol-disulphide homeostasis in patients with restless legs syndrome

Amac: Bu calisma, primer huzursuz bacak sendromu (RLS) hastalarinda yeni bir oksidatif stres belirteci olan tiyol-disulfid homeostazisini arastirmak amaciyla yapildi. Gerec ve Yontem: Otuz sekiz hasta ve 43 saglikli birey calismaya alindi. Serum nativ tiyol, total tiyol, disulfit ve disulfid / nativ tiyol oranlari yeni bir otomatik yontem kullanilarak olculmustur. RLS tanisi Uluslararasi Huzursuz Bacak Sendromu Calisma Grubu (IRLSSG) tarafindan onerilen kriterlere gore konuldu ve RLS siddeti IRLSSG Şiddet Olcegi kullanilarak degerlendirildi. Bulgular: Serum nativ tiyol ve total tiyol duzeyleri anlamli derecede dusuk (sirasiyla p<0.001; p=0.007), disulfid ve disulfid / nativ tiyol orani anlamli olarak daha yuksekti (sirasiyla p=0.017; p<0.001). RLS kontrol grubu ile karsilastirildi. IRLSSG Onem Olcegi ve tiyol-disulfid homeostasisi parametreleri arasinda anlamli korelasyonlar bulundu (r=-0.56, nativ tiyol icin p<0.001; total tiyol icin r=-0.51, p<0.001; disulfid icin r=0.37, p=0.020); r=0.60, disulfid / nativ tiyol yuzdesi orani icin p<0.001). Sonuclar: Azalmis nativ tiyol, artan disulfid seviyeleri ve artmis disulfid / nativ tiyol orani, tiyol-disulfur dengesinin oksidasyon tarafina kaydigini gostermektedir. IRLSSG Onem Olcegi ve tiyol-disulfid homeostasisi parametreleri arasindaki guclu korelasyonlar, homeostazin primer RLS'nin patogenezinde rol oynayabilecegini gostermektedir.

[1]  S. Steffensen,et al.  Peripheral Dopamine in Restless Legs Syndrome , 2018, Front. Neurol..

[2]  Ö. Erel,et al.  Thiol/disulphide homeostasis in schizophrenia patients with positive symptoms , 2018, Nordic journal of psychiatry.

[3]  A. Hartzema,et al.  Adherence and persistence to ropinirole, pramipexole, and gabapentin in patients with newly diagnosed restless legs syndrome. , 2017, Sleep medicine.

[4]  O. Erel,et al.  Impairment of dynamic thiol–disulphide homeostasis in patients with idiopathic Parkinson’s disease and its relationship with clinical stage of disease , 2017, Clinical Neurology and Neurosurgery.

[5]  A. Walters,et al.  Restless Legs Syndrome: Current Concepts about Disease Pathophysiology , 2016, Tremor and other hyperkinetic movements.

[6]  O. Erel,et al.  Evaluation of thiol levels, thiol/disulfide homeostasis and their relation with inflammation in cardiac syndrome X , 2016, Coronary artery disease.

[7]  O. Erel,et al.  The relation of serum thiol levels and thiol/disulphide homeostasis with the severity of coronary artery disease. , 2016, Kardiologia polska.

[8]  O. Erel,et al.  A novel oxidative stress marker in migraine patients: dynamic thiol–disulphide homeostasis , 2016, Neurological Sciences.

[9]  O. Erel,et al.  A novel oxidative stress marker in patients with Alzheimer’s disease: dynamic thiol–disulphide homeostasis , 2016, Acta Neuropsychiatrica.

[10]  O. Erel,et al.  Comparison of thiol/disulphide homeostasis parameters in patients with COPD, asthma and ACOS. , 2016, European review for medical and pharmacological sciences.

[11]  O. Erel,et al.  Association of thiol disulfide homeostasis with slow coronary flow , 2016, Scandinavian cardiovascular journal : SCJ.

[12]  M. Abe,et al.  Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis. , 2015, Sleep medicine.

[13]  O. Erel,et al.  Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum , 2015, Journal of Perinatology.

[14]  O. Erel,et al.  A novel and automated assay for thiol/disulphide homeostasis. , 2014, Clinical biochemistry.

[15]  Richard P Allen,et al.  Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. , 2014, Sleep medicine.

[16]  Y. Türker,et al.  Association between restless leg syndrom and slow coronary flow. , 2014, Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.

[17]  Rafael Radi,et al.  The thiol pool in human plasma: the central contribution of albumin to redox processes. , 2013, Free radical biology & medicine.

[18]  G. Baskol,et al.  Assessment of nitric oxide, advanced oxidation protein products, malondialdehyde, and thiol levels in patients with restless legs syndrome. , 2012, Sleep medicine.

[19]  J. Sztajzel,et al.  Oxidative stress and autonomic nervous system functions in restless legs syndrome , 2011, European journal of clinical investigation.

[20]  J. Mieyal,et al.  Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease. , 2010, Biochemistry.

[21]  D. Dean,et al.  Structure, function, and formation of biological iron-sulfur clusters. , 2005, Annual review of biochemistry.

[22]  M. Piercey,et al.  Pramipexole — a new dopamine agonist for the treatment of Parkinson's disease , 1999, Journal of the Neurological Sciences.

[23]  C. Peschle,et al.  Oxidative stress leads to a rapid alteration of transferrin receptor intravesicular trafficking. , 1998, Experimental cell research.

[24]  A. Camerman,et al.  Stereochemistry of dopaminergic ergoline derivatives: structures of pergolide and pergolide mesylate , 1987 .

[25]  L. Akpinar.  Restless Legs Syndrome Treatment with Dopaminergic Drugs , 1987, Clinical neuropharmacology.

[26]  N. Chasteen.  The identification of the probable locus of iron and anion binding in the transferrins , 1983 .

[27]  J. Connor,et al.  Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. , 2018, Sleep medicine.

[28]  W. Oertel,et al.  Restless legs syndrome in Parkinson's disease and other neurodegenerative diseases of the central nervous system , 2007, Movement disorders : official journal of the Movement Disorder Society.

[29]  J. Kehr,et al.  Determination of the dopamine agonist rotigotine in microdialysates from the rat brain by microbore column liquid chromatography with electrochemical detection. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[30]  R. Crichton.  Structure and function of ferritin. , 1973, Angewandte Chemie.