Protein engineering approaches to chemical biotechnology.

[1]  Huimin Zhao,et al.  Regeneration of cofactors for use in biocatalysis. , 2003, Current opinion in biotechnology.

[2]  C. Nakamura,et al.  Metabolic engineering for the microbial production of 1,3-propanediol. , 2003, Current opinion in biotechnology.

[3]  J. Mielenz,et al.  High-Yield Hydrogen Production from Starch and Water by a Synthetic Enzymatic Pathway , 2007, PloS one.

[4]  D. Shonnard,et al.  Improved activity and thermostability of (S)-aminotransferase by error-prone polymerase chain reaction for the production of a chiral amine , 2007 .

[5]  J. Liao,et al.  Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels , 2008, Nature.

[6]  P. Babbitt,et al.  Enzyme (re)design: lessons from natural evolution and computation. , 2009, Current opinion in chemical biology.

[7]  J. Mielenz,et al.  Spontaneous high-yield production of hydrogen from cellulosic materials and water catalyzed by enzyme cocktails. , 2009, ChemSusChem.

[8]  Kelly M. Thayer,et al.  Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control , 2010, Proceedings of the National Academy of Sciences.

[9]  A. Zeng,et al.  Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development. , 2010, Trends in biotechnology.

[10]  Hongjuan Liu,et al.  Elementary Mode Analysis for the Rational Design of Efficient Succinate Conversion from Glycerol by Escherichia coli , 2010, Journal of biomedicine & biotechnology.

[11]  V. Hatzimanikatis,et al.  Discovery and analysis of novel metabolic pathways for the biosynthesis of industrial chemicals: 3‐hydroxypropanoate , 2010, Biotechnology and bioengineering.

[12]  J. Keasling Manufacturing Molecules Through Metabolic Engineering , 2010, Science.

[13]  Hongjuan Liu,et al.  Metabolic pathway analysis of 1,3-propanediol production with a genetically modified Klebsiella pneumoniae by overexpressing an endogenous NADPH-dependent alcohol dehydrogenase , 2011 .

[14]  A. Zeng,et al.  Integrating molecular dynamics and co-evolutionary analysis for reliable target prediction and deregulation of the allosteric inhibition of aspartokinase for amino acid production. , 2011, Journal of biotechnology.

[15]  Pablo Carbonell,et al.  A retrosynthetic biology approach to metabolic pathway design for therapeutic production , 2011, BMC Systems Biology.

[16]  A. Zeng,et al.  Coevolutionary Analysis Enabled Rational Deregulation of Allosteric Enzyme Inhibition in Corynebacterium glutamicum for Lysine Production , 2011, Applied and Environmental Microbiology.

[17]  A. Burgard,et al.  Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol. , 2011, Nature chemical biology.

[18]  A. Zeng,et al.  Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production , 2013, Applied Microbiology and Biotechnology.

[19]  G. Huisman,et al.  Engineering the third wave of biocatalysis , 2012, Nature.

[20]  F. G. Mutti,et al.  Redox self-sufficient biocatalyst network for the amination of primary alcohols. , 2012, Angewandte Chemie.

[21]  A. Zeng,et al.  Discovery of Intramolecular Signal Transduction Network Based on a New Protein Dynamics Model of Energy Dissipation , 2012, PloS one.

[22]  D. Weuster‐Botz,et al.  Engineering of formate dehydrogenase: synergistic effect of mutations affecting cofactor specificity and chemical stability , 2012, Applied Microbiology and Biotechnology.

[23]  A. Zeng,et al.  Study and reengineering of the binding sites and allosteric regulation of biosynthetic threonine deaminase by isoleucine and valine in Escherichia coli , 2013, Applied Microbiology and Biotechnology.

[24]  C. You,et al.  Facilitated substrate channeling in a self-assembled trifunctional enzyme complex. , 2012, Angewandte Chemie.

[25]  A. Zeng,et al.  Compartmentalization and metabolic channeling for multienzymatic biosynthesis: practical strategies and modeling approaches. , 2013, Advances in biochemical engineering/biotechnology.

[26]  A. Zeng,et al.  Protein design in systems metabolic engineering for industrial strain development , 2013, Biotechnology journal.

[27]  An-Ping Zeng,et al.  Proteindesign für die Entwicklung von industriellen Mikroorganismen , 2013, BIOspektrum.

[28]  Tsz Kin Tam,et al.  New biotechnology paradigm: cell-free biosystems for biomanufacturing , 2013 .

[29]  A. Bommarius,et al.  The Evolution of an Amine Dehydrogenase Biocatalyst for the Asymmetric Production of Chiral Amines , 2013 .

[30]  Peng Xu,et al.  Pathway and protein engineering approaches to produce novel and commodity small molecules. , 2013, Current opinion in biotechnology.

[31]  A. Zeng,et al.  Deregulation of Feedback Inhibition of Phosphoenolpyruvate Carboxylase for Improved Lysine Production in Corynebacterium glutamicum , 2013, Applied and Environmental Microbiology.

[32]  A. Zeng,et al.  In vitro multienzymatic reaction systems for biosynthesis. , 2013, Advances in biochemical engineering/biotechnology.

[33]  Huimin Zhao,et al.  Directed evolution of a cellobiose utilization pathway in Saccharomyces cerevisiae by simultaneously engineering multiple proteins , 2013, Microbial Cell Factories.

[34]  An-Ping Zeng,et al.  In silico evaluation of a complex multi-enzymatic system using one-pot and modular approaches: Application to the high-yield production of hydrogen from a synthetic metabolic pathway , 2013 .

[35]  A. Skerra,et al.  Coupled Enzymatic Alcohol‐to‐Amine Conversion of Isosorbide using Engineered Transaminases and Dehydrogenases , 2013 .

[36]  Christopher M Pirie,et al.  Integrating the protein and metabolic engineering toolkits for next-generation chemical biosynthesis. , 2013, ACS chemical biology.

[37]  Joseph A. Rollin,et al.  High-yield production of dihydrogen from xylose by using a synthetic enzyme cascade in a cell-free system. , 2013, Angewandte Chemie.

[38]  H. Gröger,et al.  Strategies for regeneration of nicotinamide coenzymes emphasizing self-sufficient closed-loop recycling systems. , 2014, Journal of biotechnology.

[39]  T. Iverson,et al.  Bioretrosynthetic construction of a didanosine biosynthetic pathway , 2014, Nature chemical biology.

[40]  A. Zeng,et al.  A de novo NADPH generation pathway for improving lysine production of Corynebacterium glutamicum by rational design of the coenzyme specificity of glyceraldehyde 3-phosphate dehydrogenase. , 2014, Metabolic engineering.

[41]  Joseph A. Rollin,et al.  In vitro metabolic engineering of hydrogen production at theoretical yield from sucrose. , 2014, Metabolic engineering.

[42]  A. Bommarius,et al.  A novel chimeric amine dehydrogenase shows altered substrate specificity compared to its parent enzymes. , 2014, Chemical communications.

[43]  Adam M. Feist,et al.  Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path. , 2014, Metabolic engineering.

[44]  Yanping Zhang,et al.  Design and Construction of a Non-Natural Malate to 1,2,4-Butanetriol Pathway Creates Possibility to Produce 1,2,4-Butanetriol from Glucose , 2014, Scientific Reports.

[45]  P. Cirino,et al.  Recent advances in engineering proteins for biocatalysis , 2014, Biotechnology and bioengineering.

[46]  A. Zeng,et al.  Cell‐free synthesis of 1,3‐propanediol from glycerol with a high yield , 2014 .

[47]  D. Mink,et al.  Cofactor Specificity Engineering of Streptococcus mutans NADH Oxidase 2 for NAD(P)+ Regeneration in Biocatalytic Oxidations , 2014, Computational and structural biotechnology journal.

[48]  C. You,et al.  Annexation of a high-activity enzyme in a synthetic three-enzyme complex greatly decreases the degree of substrate channeling. , 2014, ACS synthetic biology.

[49]  Sang Yup Lee,et al.  Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering. , 2015, Biotechnology advances.

[50]  A. Zeng,et al.  Protein design and engineering of a de novo pathway for microbial production of 1,3-propanediol from glucose. , 2015, Biotechnology journal.

[51]  Ashty S. Karim,et al.  Cell‐free metabolic engineering: Biomanufacturing beyond the cell , 2015, Biotechnology journal.

[52]  Jung-Min Choi,et al.  Industrial applications of enzyme biocatalysis: Current status and future aspects. , 2015, Biotechnology advances.

[53]  A. Zeng,et al.  Rational design of allosteric regulation of homoserine dehydrogenase by a nonnatural inhibitor L-lysine. , 2015, ACS synthetic biology.

[54]  Zachary N. Russ,et al.  An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. , 2015, Nature chemical biology.

[55]  N. Scrutton,et al.  Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades , 2015, Science.

[56]  S. Lee,et al.  Systems strategies for developing industrial microbial strains , 2015, Nature Biotechnology.

[57]  Zhen Chen,et al.  Metabolic Engineering of Klebsiella pneumoniae for the Production of 2-Butanone from Glucose , 2015, PloS one.

[58]  U. Bornscheuer,et al.  Cascade catalysis--strategies and challenges en route to preparative synthetic biology. , 2015, Chemical communications.

[59]  Amanda L. Smith,et al.  Computational protein design enables a novel one-carbon assimilation pathway , 2015, Proceedings of the National Academy of Sciences.

[60]  Zhen Chen,et al.  Metabolic engineering of Klebsiella pneumoniae for the de novo production of 2-butanol as a potential biofuel. , 2015, Bioresource technology.

[61]  T. Maoka,et al.  A highly selective biosynthetic pathway to non-natural C50 carotenoids assembled from moderately selective enzymes , 2015, Nature Communications.

[62]  A. Zeng,et al.  Exploring signal transduction in heteromultimeric protein based on energy dissipation model , 2015, Journal of biomolecular structure & dynamics.

[63]  Seung Hwan Lee,et al.  Enhanced production of gamma-aminobutyrate (GABA) in recombinant Corynebacterium glutamicum by expressing glutamate decarboxylase active in expanded pH range , 2015, Microbial Cell Factories.

[64]  De-hua Liu,et al.  Metabolic engineering of Corynebacterium glutamicum for the de novo production of ethylene glycol from glucose. , 2016, Metabolic engineering.

[65]  A. Zeng,et al.  Protein and pathway engineering for the biosynthesis of 5‐hydroxytryptophan in Escherichia coli , 2017, Engineering in life sciences.