Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface

[1]  Jie Zhou,et al.  Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo. , 2016, ACS infectious diseases.

[2]  Jie Zhou,et al.  A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication. , 2016, The Journal of antimicrobial chemotherapy.

[3]  L. Goracci,et al.  Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Protein-Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics. , 2016, Journal of medicinal chemistry.

[4]  Jie Zhou,et al.  A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase , 2016, Scientific Reports.

[5]  Jie Zhou,et al.  Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase. , 2016, Antiviral research.

[6]  D. Stuart,et al.  Crystal structure of the RNA-dependent RNA polymerase from influenza C virus , 2015, Nature.

[7]  Tokiko Watanabe,et al.  Influenza virus-host interactomes as a basis for antiviral drug development. , 2015, Current opinion in virology.

[8]  Jie Zhou,et al.  Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain , 2015, Antimicrobial Agents and Chemotherapy.

[9]  G. Neumann,et al.  At the centre: influenza A virus ribonucleoproteins , 2014, Nature Reviews Microbiology.

[10]  S. Cusack,et al.  Structure of influenza A polymerase bound to the viral RNA promoter , 2014, Nature.

[11]  Stefan Reich,et al.  Structural insight into cap-snatching and RNA synthesis by influenza polymerase , 2014, Nature.

[12]  Yuna Sun,et al.  Current progress in antiviral strategies , 2014, Trends in Pharmacological Sciences.

[13]  Min-Sung Kim,et al.  Transient mammalian cell transfection with polyethylenimine (PEI). , 2013, Methods in enzymology.

[14]  D. Smee,et al.  Exacerbation of Influenza Virus Infections in Mice by Intranasal Treatments and Implications for Evaluation of Antiviral Drugs , 2012, Antimicrobial Agents and Chemotherapy.

[15]  Aeron C. Hurt,et al.  The Ongoing Battle Against Influenza: Drug-resistant influenza viruses: why fitness matters , 2012, Nature Medicine.

[16]  Giorgio Palù,et al.  Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase , 2012, Proceedings of the National Academy of Sciences.

[17]  L. Kakkola,et al.  Emerging cellular targets for influenza antiviral agents. , 2012, Trends in pharmacological sciences.

[18]  M. Ison Antivirals and resistance: influenza virus. , 2011, Current opinion in virology.

[19]  L. Brunotte,et al.  Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences , 2011, Journal of Virology.

[20]  Hideo Goto,et al.  Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA. , 2011, Journal of virological methods.

[21]  Kai-Cheng Hsu,et al.  iGEMDOCK: a graphical environment of enhancing GEMDOCK using pharmacological interactions and post-screening analysis , 2011, BMC Bioinformatics.

[22]  F. Hayden,et al.  Emerging influenza antiviral resistance threats. , 2011, The Journal of infectious diseases.

[23]  Ke Zhang,et al.  D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice , 2010, Experimental biology and medicine.

[24]  Yi Guan,et al.  Identification of influenza A nucleoprotein as an antiviral target , 2010, Nature Biotechnology.

[25]  James M Aramini,et al.  Structures of influenza A proteins and insights into antiviral drug targets , 2010, Nature Structural &Molecular Biology.

[26]  E. Obayashi,et al.  Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase , 2009, The EMBO journal.

[27]  A. Joachimiak,et al.  Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus , 2008, Nature.

[28]  E. Obayashi,et al.  The structural basis for an essential subunit interaction in influenza virus RNA polymerase , 2008, Nature.

[29]  Samson S. Y. Wong,et al.  Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus , 2008, Proceedings of the National Academy of Sciences.

[30]  Ruth Nussinov,et al.  FireDock: a web server for fast interaction refinement in molecular docking† , 2008, Nucleic Acids Res..

[31]  P. Leeson,et al.  The influence of drug-like concepts on decision-making in medicinal chemistry , 2007, Nature Reviews Drug Discovery.

[32]  Ronald Frank,et al.  Peptide-Mediated Interference with Influenza A Virus Polymerase , 2007, Journal of Virology.

[33]  George G. Brownlee,et al.  In Vitro Assembly of PB2 with a PB1-PA Dimer Supports a New Model of Assembly of Influenza A Virus Polymerase Subunits into a Functional Trimeric Complex , 2005, Journal of Virology.

[34]  Ruth Nussinov,et al.  PatchDock and SymmDock: servers for rigid and symmetric docking , 2005, Nucleic Acids Res..

[35]  C. Lipinski Lead- and drug-like compounds: the rule-of-five revolution. , 2004, Drug discovery today. Technologies.

[36]  Herman Tse,et al.  Identification of Novel Small-Molecule Inhibitors of Severe Acute Respiratory Syndrome-Associated Coronavirus by Chemical Genetics , 2004, Chemistry & Biology.

[37]  P. Digard,et al.  Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites. , 2004, Virology.

[38]  D. Walker Functional Domains , 1996 .

[39]  R. Taylor,et al.  EXPERIMENTAL INFECTION WITH INFLUENZA A VIRUS IN MICE , 1941, The Journal of experimental medicine.