Randomised controlled trial

Context Gastro-oesophageal reflux disease (GORD) is common in western countries. Up to 40% experience symptoms at least once a month and 10% of adults use proton pump inhibitor (PPI) medication for GORD. The REFLUX study addresses a question fundamental to the management of this problem: what is the best treatment strategy? The current study reports 5-year outcomes of a multicentre randomised clinical trial of surgery versus medical management in the UK.