Vibrotactile amplitude discrimination capacity parallels magnitude changes in somatosensory cortex and follows Weber’s Law

In this study, we investigated the changes in perceptual metrics of amplitude discrimination that were observed in ten healthy human subjects with increasing intensities of stimulation. The ability to perceive differences in vibrotactile amplitude changed systematically with increasing stimulus magnitude (i.e., followed Weber’s Law) in a near linear fashion (R2 = 0.9977), and the linear fit determined by the amplitude discrimination task predicted the subjects’ detection thresholds. Additionally, the perceptual metrics correlated well with observations from a previously reported study in which measures of SI cortical activity in non-human primates (squirrel monkeys) evoked by different amplitudes of vibrotactile stimulation were obtained (Simons et al. in BMC Neurosci 6:43, 2005). Stimuli were delivered simultaneously to two different skin sites (D2 and D3), enabling a method for the relatively rapid acquisition of the data. Stability and robustness of the measure, its rapid acquisition, and its apparent relationship with responses previously observed in SI cortex, led to the conclusion that deviations from the baseline values observed in the obtained perceptual metric could provide a useful indicator of cerebral cortical health.

[1]  V. Mountcastle,et al.  THE RELATION OF THALAMIC CELL RESPONSE TO PERIPHERAL STIMULI VARIED OVER AN INTENSIVE CONTINUUM. , 1963, Journal of neurophysiology.

[2]  V. Mountcastle,et al.  NEURAL ACTIVITY IN MECHANORECEPTIVE CUTANEOUS AFFERENTS: STIMULUS-RESPONSE RELATIONS, WEBER FUNCTIONS, AND INFORMATION TRANSMISSION. , 1965, Journal of neurophysiology.

[3]  K. O. Johnson,et al.  Reconstruction of population response to a vibratory stimulus in quickly adapting mechanoreceptive afferent fiber population innervating glabrous skin of the monkey. , 1974, Journal of neurophysiology.

[4]  D. Simons.  Response properties of vibrissa units in rat SI somatosensory neocortex. , 1978, Journal of neurophysiology.

[5]  R. Llinás,et al.  Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. , 1980, The Journal of physiology.

[6]  J. Moran,et al.  Sensation and perception , 1980 .

[7]  D M Green,et al.  Detection and intensity discrimination of a sinusoid. , 1984, The Journal of the Acoustical Society of America.

[8]  J. S. McCasland,et al.  High‐resolution 2‐deoxyglucose mapping of functional cortical columns in mouse barrel cortex , 1988, The Journal of comparative neurology.

[9]  S. Bolanowski,et al.  Vibrotactile intensity discrimination measured by three methods. , 1990, The Journal of the Acoustical Society of America.

[10]  C. Connor,et al.  Tactile roughness: neural codes that account for psychophysical magnitude estimates , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[11]  B L Whitsel,et al.  Minicolumnar activation patterns in cat and monkey SI cortex. , 1993, Cerebral cortex.

[12]  M. Hollins,et al.  Vibrotactile adaptation enhances amplitude discrimination. , 1993, The Journal of the Acoustical Society of America.

[13]  J A Stillman,et al.  Intensity just-noticeable differences at equal-loudness levels in normal and pathological ears. , 1993, The Journal of the Acoustical Society of America.

[14]  M. Hollins,et al.  Vibrotactile adaptation enhances frequency discrimination. , 1994, The Journal of the Acoustical Society of America.

[15]  R W Cholewiak,et al.  Vibrotactile threshold in young and old observers: the effects of spatial summation and the presence of a rigid surround. , 1996, The Journal of the Acoustical Society of America.

[16]  G A Gescheider,et al.  Effects of stimulus duration on the amplitude difference limen for vibrotaction. , 1996, The Journal of the Acoustical Society of America.

[17]  J. Ekholm,et al.  Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls , 1996, Pain.

[18]  M. Hollins,et al.  Vibrotactile threshold is elevated in temporomandibular disorders , 1996, PAIN.

[19]  O. Franzén,et al.  Somesthesis and the Neurobiology of the Somatosensory Cortex , 1996, Advances in Life Sciences.

[20]  S J Bolanowski,et al.  The effects of aging on information-processing channels in the sense of touch: III. Differential sensitivity to changes in stimulus intensity. , 1996, Somatosensory & motor research.

[21]  Douglas G. Kelly,et al.  Local receptive field diversity within cortical neuronal populations , 1996 .

[22]  S J Bolanowski,et al.  The effects of skin temperature on the detection and discrimination of tactile stimulation. , 1997, Somatosensory & motor research.

[23]  Asgeir Sigurdsson,et al.  Vibrotactile amplitude and frequency discrimination in temporomandibular disorders , 1998, Pain.

[24]  S J Bolanowski,et al.  Vibrotactile temporal summation: probability summation or neural integration? , 1999, Somatosensory & motor research.

[25]  W. Backes,et al.  Somatosensory cortex responses to median nerve stimulation: fMRI effects of current amplitude and selective attention , 2000, Clinical Neurophysiology.

[26]  B L Whitsel,et al.  Stability of rapidly adapting afferent entrainment vs responsivity. , 2000, Somatosensory & motor research.

[27]  T. Carpenter,et al.  Linear coupling between functional magnetic resonance imaging and evoked potential amplitude in human somatosensory cortex , 2000, Neuroscience.

[28]  Claudio Babiloni,et al.  Comparison between SI and SII responses as a function of stimulus intensity , 2002, Neuroreport.

[29]  Mark Tommerdahl,et al.  Optical imaging of intrinsic signals in somatosensory cortex , 2002, Behavioural Brain Research.

[30]  Christian Füllgrabe,et al.  Temporal envelope perception in dyslexic children , 2002, Neuroreport.

[31]  Yoko Hoshi,et al.  Selective attention regulates spatial and intensity information processing in the human primary somatosensory cortex , 2002, Neuroreport.

[32]  Kenneth O. Johnson,et al.  Review: Neural Coding and the Basic Law of Psychophysics , 2002, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[33]  D. Simons,et al.  Thalamocortical Angular Tuning Domains within Individual Barrels of Rat Somatosensory Cortex , 2003, The Journal of Neuroscience.

[34]  Anders M. Dale,et al.  Optical Imaging of a Tactile Illusion in Area 3b of the Primary Somatosensory Cortex , 2003 .

[35]  S. J. Bolanowski,et al.  Some characteristics of tactile channels , 2004, Behavioural Brain Research.

[36]  Burak Güçlü,et al.  Modeling Population Responses of Rapidly-Adapting Mechanoreceptive Fibers , 2002, Journal of Computational Neuroscience.

[37]  Simon J Graham,et al.  Activation in SI and SII: the influence of vibrotactile amplitude during passive and task-relevant stimulation. , 2004, Brain research. Cognitive brain research.

[38]  B. Whitsel,et al.  Minicolumnar Patterns in the Global Cortical Response to Sensory Stimulation , 2005 .

[39]  Response of SII cortex to ipsilateral, contralateral and bilateral flutter stimulation in the cat , 2005, BMC neuroscience.

[40]  Mark Tommerdahl,et al.  Amplitude-dependency of response of SI cortex to flutter stimulation , 2005, BMC Neuroscience.

[41]  V. Tannan,et al.  A novel device for delivering two-site vibrotactile stimuli to the skin , 2005, Journal of Neuroscience Methods.

[42]  B. Whitsel,et al.  Stimulus-dependent spatial patterns of response in SI cortex , 2005, BMC Neuroscience.

[43]  Mark Tommerdahl,et al.  Ipsilateral Input Modifies the Primary Somatosensory Cortex Response to Contralateral Skin Flutter , 2006, The Journal of Neuroscience.

[44]  Barry L. Whitsel,et al.  Vibrotactile adaptation enhances spatial localization , 2006, Brain Research.

[45]  B. Whitsel,et al.  Duration-dependent response of SI to vibrotactile stimulation in squirrel monkey. , 2007, Journal of neurophysiology.

[46]  V. Tannan,et al.  A portable tactile sensory diagnostic device , 2007, Journal of Neuroscience Methods.

[47]  Burak Güçlü,et al.  Tactile sensitivity of normal and autistic children , 2007, Somatosensory & motor research.

[48]  R. Defrin,et al.  The characteristics of chronic central pain after traumatic brain injury , 2007, PAIN.

[49]  Evaluation of the dynamics of sensory improvement in the hand after surgical treatment of carpal tunnel syndrome. , 2007, Neurologia i neurochirurgia polska.

[50]  V. Tannan,et al.  Effects of adaptation on the capacity to differentiate simultaneously delivered dual-site vibrotactile stimuli , 2007, Brain Research.

[51]  V. Tannan,et al.  Vibrotactile adaptation fails to enhance spatial localization in adults with autism , 2007, Brain Research.

[52]  Mark Tommerdahl,et al.  Effects of stimulus-driven synchronization on sensory perception , 2007, Behavioral and Brain Functions.

[53]  V. Tannan,et al.  Effects of the N-methyl-D-Aspartate receptor antagonist dextromethorphan on vibrotactile adaptation , 2008, BMC Neuroscience.

[54]  Mark Tommerdahl,et al.  Absence of stimulus-driven synchronization effects on sensory perception in autism: Evidence for local underconnectivity? , 2008, Behavioral and Brain Functions.

[55]  G. Dehnhardt,et al.  Brightness discrimination in the harbor seal (Phoca vitulina) , 2008, Vision Research.

[56]  Franco Lepore,et al.  Tactile acuity in the blind: a psychophysical study using a two-dimensional angle discrimination task , 2008, Experimental Brain Research.

[57]  Mark Tommerdahl,et al.  A quantitative method for determining spatial discriminative capacity , 2008, Biomedical engineering online.

[58]  G. Baranek,et al.  Perceptual metrics of individuals with autism provide evidence for disinhibition , 2008, Autism research : official journal of the International Society for Autism Research.