Effects of histaminergic drugs on muricide induced by thiamine deficiency.

Male Wistar rats maintained on a thiamine deficient diet showed mouse-killing aggression (muricide). On the 30th day of experimental feeding, the incidence of this muricide was about 70%. Intracerebroventricular histamine suppressed the muricide induced by thiamine deficiency in a dose-dependent manner. Histamine H1-receptor blocking agents such as diphenhydramine, promethazine and chlorpheniramine also showed muricidal suppression, but astemizole which lacks central effects did not show muricidal suppression. Mianserin and iprindole showed muricidal suppression, but metiamide i.p. did not. On the 20th day of experimental feeding, the incidence of this muricide was 45.5%. Histamine synthesis inhibitors such as brocresine or alpha-fluoromethylhistidine could not enhance the muricide on non-killer-rats, but really suppressed the thiamine deficient killer-rats. The results of this paper suggested that muricide induced by thiamine deficiency is not mediated by the central histaminergic system, but pharmacologically characterized by antidepressants, antihistamines and histamine synthesis inhibitors.

[1]  M. Reilly,et al.  Suppression of histamine-induced adrenocorticotropic hormone release by antihistamines and antidepressants. , 1982, The Journal of pharmacology and experimental therapeutics.

[2]  T. Sullivan Pharmacologic modulation of the whealing response to histamine in human skin: identification of doxepin as a potent in vivo inhibitor. , 1982, The Journal of allergy and clinical immunology.

[3]  K. Onodera,et al.  Characteristics of muricide induced by thiamine deficiency and its suppression by antidepressants or intraventricular serotonin , 1981, Physiology & Behavior.

[4]  F. Awouters,et al.  A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs , 1981, Neuropharmacology.

[5]  T. Kamioka,et al.  [Behavioral pharmacology of mianserin hydrochloride, a new antidepressant (author's transl)]. , 1980, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[6]  J. Schwartz,et al.  Histamine as a Neurotransmitter in Mammalian Brain: Neurochemical Evidence , 1980, Journal of neurochemistry.

[7]  B. Bielkiewicz,et al.  Dimaprit-induced hypothermia in normal rats: Its attenuation by cimetidine and by tricyclic antidepressant drugs , 1979, Neuropharmacology.

[8]  K. Onodera,et al.  Effect of 5-hydroxytryptophan on muricide response induced by thiamine deficiency. , 1979, Archives internationales de pharmacodynamie et de therapie.

[9]  G. Barr,et al.  Manipulations of dietary tryptophan: Effects on mouse killing and brain serotonin in the rat , 1979, Brain Research.

[10]  A. Patchett,et al.  Selective inhibitors of biosynthesis of aminergic neurotransmitters , 1978, Nature.

[11]  K. Onodera,et al.  [Muricide induced by thiamine deficiency in the rats (author's transl)]. , 1978, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[12]  G. Barr,et al.  Effects of para-chlorophenylalanine and 5-hydroxytryptophan on mouse killing behavior in killer rats , 1978, Pharmacology Biochemistry and Behavior.

[13]  P. Greengard,et al.  Brain histamine receptors as targets for antidepressant drugs , 1978, Nature.

[14]  J. Green,et al.  Tricyclic antidepressant drugs block histamine H2 receptor in brain , 1977, Nature.

[15]  J. C. Emmett,et al.  Some chemical aspects of histamine H2-receptor antagonists. , 1976, Federation proceedings.

[16]  S. Snyder,et al.  Histamine in rat brain: sensitive assay of endogenous levels, formation in vivo and lowering by inhibitors of histidine decarboxylase. , 1971, The Journal of pharmacology and experimental therapeutics.

[17]  G. Chiara,et al.  Evidence for Inhibition by Brain Serotonin of Mouse Killing Behaviour in Rats , 1971, Nature.

[18]  T. Hökfelt,et al.  Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine. , 1969, European journal of pharmacology.

[19]  P. Kielholz,et al.  [Management of endogenous depressions using psychopharmacologic agents]. , 1968, Deutsche medizinische Wochenschrift.

[20]  Z. Horovitz,et al.  Selective block of rat mouse-killing by antidepressants. , 1965, Life sciences.

[21]  R. Gundlach,et al.  DIPHENHYDRAMINE AS AN ANTIDEPRESSANT: A NEGATIVE FINDING. , 1964, Diseases of the nervous system.

[22]  F. Wilcoxon,et al.  A simplified method of evaluating dose-effect experiments. , 1948, The Journal of pharmacology and experimental therapeutics.

[23]  J. Schwartz,et al.  Histamine receptors in brain as targets for tricyclic antidepressants , 1981 .

[24]  J. Schwartz,et al.  Histaminergic Systems in Brain , 1979 .

[25]  Wallach Mb,et al.  The effects of antihistamines in a modified behavioral despair test. , 1979 .

[26]  G. Paxinos,et al.  5, 7‐dihydroxytryptamine lesions: Effects on body weight, irritability, and muricide , 1977 .

[27]  A. Barnett,et al.  Activity of antihistamines in laboratory antidepressant tests. , 1969, International journal of neuropharmacology.

[28]  L. Pellegrino,et al.  stereotaxic atlas of the rat brain , 1967 .