The Thy‐I epidermal cell: perspective and prospective

Recently a class of cells distinguished by the presence of the cell‐surface protein, Thy‐I, has been discovered in the epidermis. These cells constitute a heterogeneous population such that they may be dendritic or round, and may be derived from both mesenchymal and ectodermal tissue. Phenotypically, cells with the following characteristics have been observed: Thy‐I +, Vim +; Thy‐I+, Vim‐; Thy‐I+, Ker+; Thy‐I+, Ker‐; Thy‐I +, asialo GMI+; Thy‐I +, asialo GMI ‐. Thy‐I + epidermal cells do not appear to be T or B lymphocytes, macrophage/monocytes or melanocytes. The Thy‐I+ epidermal cell can be studied in in vivo and in vitro systems. It would appear that skin as well as the immune system contain Thy‐I+ and Ia + cells. Such cells may he prerequisite for both systems to carry out their primary defense functions.

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