Project. Development of the use of protons in oncological therapy. Report on research activities in the fields of biophysics, radiobiology, dosimetry and development of software packages and treatment planning.

[1]  R Mohan,et al.  Algorithms and functionality of an intensity modulated radiotherapy optimization system. , 2000, Medical physics.

[2]  R K Ten Haken,et al.  Partial irradiation of the liver. , 2001, Seminars in radiation oncology.

[3]  C E Mountford,et al.  Human cancers detected by proton MRS and chemical shift imaging ex vivo. , 1996, Anticancer research.

[4]  Yutaka Tsutsumi,et al.  Gastric carcinoma with lymphoid stroma , 2004, Virchows Archiv A.

[5]  M Belli,et al.  A semi-microscopic model for the evaluation of radiation damage. , 2002, Radiation protection dosimetry.

[6]  M Pugliese,et al.  Inactivation of human normal and tumour cells irradiated with low energy protons. , 2000, International journal of radiation biology.

[7]  G. Trinchieri,et al.  Preferential proliferation of natural killer cells among peripheral blood mononuclear cells cocultured with B lymphoblastoid cell lines. , 1987, Natural immunity and cell growth regulation.

[8]  Xing Wu,et al.  A global optimization method for three-dimensional conformal radiotherapy treatment planning , 2001, Physics in medicine and biology.

[9]  E Grusell,et al.  General characteristics of the use of silicon diode detectors for clinical dosimetry in proton beams. , 2000, Physics in medicine and biology.

[10]  M. Durante,et al.  Chromatid break rejoining and exchange aberration formation following gamma-ray exposure: analysis in G2 human fibroblasts by chemically induced premature chromosome condensation. , 1999, International journal of radiation biology.

[11]  C. Birattari,et al.  Relative biological effectiveness for protons of energies up to 31 MeV. , 1979, Radiation research.

[12]  P Chauvel,et al.  Clinical and technical requirements for proton treatment planning of ocular diseases. The SERAG (South Europe Radiotherapy Group). , 1997, Frontiers of radiation therapy and oncology.

[13]  Bernard Gottschalk,et al.  Charge-balancing current integrator with large dynamic range , 1983 .

[14]  W Friedland,et al.  Simulation of DNA fragment distributions after irradiation with photons , 1999, Radiation and environmental biophysics.

[15]  Skarsgard Ld,et al.  Radiobiology with heavy charged particles: a historical review. , 1998 .

[16]  P Chauvel,et al.  The depth-dependent radiation response of human melanoma cells exposed to 65 MeV protons. , 1994, The British journal of radiology.

[17]  Arne Miller,et al.  Novel Radiochromic Films for Clinical Dosimetry , 1996 .

[18]  Peter Jacob,et al.  Simulation of DNA Damage after Proton Irradiation , 2003, Radiation research.

[19]  L. Dewit,et al.  Combined treatment of radiation and cisdiamminedichloroplatinum (II): a review of experimental and clinical data. , 1987, International journal of radiation oncology, biology, physics.

[20]  Maria Antonella Tabocchini,et al.  Proton irradiation facility for radiobiological studies at a 7 MV Van de Graaff accelerator , 1987 .

[21]  P. Andreo,et al.  Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry based on Standards of Absorbed Dose to Water , 2001 .

[22]  M. Butson,et al.  Radiochromic film dosimetry in water phantoms , 2001, Physics in medicine and biology.

[23]  Christopher A. Lepre,et al.  Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA , 1990 .

[24]  I Barba,et al.  The relationship between nuclear magnetic resonance-visible lipids, lipid droplets, and cell proliferation in cultured C6 cells. , 1999, Cancer research.

[25]  H. Kanegane,et al.  Differential protective action of cytokines on radiation-induced apoptosis of peripheral lymphocyte subpopulations. , 1995, Cellular immunology.

[26]  A Ottolenghi,et al.  Long-term cardiac mortality after radiotherapy of breast cancer--application of the relative seriality model. , 1996, The British journal of radiology.

[27]  U Oppitz,et al.  The in vitro colony assay: a predictor of clinical outcome , 2001, International journal of radiation biology.

[28]  A. Ferrari,et al.  Physical and biophysical characteristics of a fully modulated 72 MeV therapeutic proton beam: model predictions and experimental data , 1999 .

[29]  F Ianzini,et al.  RBE-LET relationships for cell inactivation and mutation induced by low energy protons in V79 cells: further results at the LNL facility. , 1998, International journal of radiation biology.

[30]  F Ballarini,et al.  Modelling study on the protective role of OH radical scavengers and DNA higher‐order structures in induction of single‐ and double‐strand break by gamma‐radiation , 2003, International journal of radiation biology.

[31]  K M Prise,et al.  Use of radiation quality as a probe for DNA lesion complexity. , 1994, International journal of radiation biology.

[32]  A Dritschilo,et al.  Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy. , 1988, International journal of radiation oncology, biology, physics.

[33]  L Lindborg,et al.  Experimental limitations in microdosimetry measurements using the variance technique , 1981, Radiation and environmental biophysics.

[34]  J F Williamson,et al.  Quantitative evaluation of radiochromic film response for two-dimensional dosimetry. , 1997, Medical physics.

[35]  Walter Murray,et al.  Construction of a three-dimensional geometric model for segmentation and visualization of cervical spine images , 1996 .

[36]  K. Sasai,et al.  Prediction of human cell radiosensitivity: comparison of clonogenic assay with chromosome aberrations scored using premature chromosome condensation with fluorescence in situ hybridization. , 1994, International journal of radiation oncology, biology, physics.

[37]  T Kanai,et al.  Change in radiosensitivity with fractionated-dose irradiation of carbon-ion beams in five different human cell lines. , 2000, International journal of radiation oncology, biology, physics.

[38]  M Silari,et al.  Proton beam dosimetry: a comparison between the Faraday cup and an ionization chamber. , 1997, Physics in medicine and biology.

[39]  M Pugliese,et al.  Inactivation of human cells exposed to fractionated doses of low energy protons: relationship between cell sensitivity and recovery efficiency. , 1998, Journal of radiation research.

[40]  James A. Sethian,et al.  Level Set Methods for Curvature Flow, Image Enchancement, and Shape Recovery in Medical Images , 1997, VisMath.

[41]  P. Almond,et al.  Electron beam dose calculations , 1981, Physics in medicine and biology.

[42]  Julie Brittenden,et al.  Natural killer cells and cancer , 1996, Cancer.

[43]  E. Gorelik,et al.  Depression of natural antitumor resistance of C57BL/6 mice by leukemogenic doses of radiation and restoration of resistance by transfer of bone marrow or spleen cells from normal, but not beige, syngeneic mice. , 1982, Journal of the National Cancer Institute.

[44]  A J Lomax,et al.  A treatment planning inter-comparison of proton and intensity modulated photon radiotherapy. , 1999, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[45]  G. Moschini,et al.  RBE-LET relationship for the survival of V79 cells irradiated with low energy protons. , 1989, International journal of radiation biology.

[46]  Michael Unser,et al.  Multiscale B-spline snakes for general contour detection , 1998, Optics & Photonics.

[47]  Edward G. Shapiro,et al.  Linear Seven-Decade Current/Voltage-to-Frequency Converter , 1970 .

[48]  M G Lötter,et al.  Chelator effect on ion diffusion in ferrous-sulfate-doped gelatin gel dosimeters as analyzed by MRI. , 1996, Medical physics.

[49]  D Blöcher,et al.  In CHEF electrophoresis a linear induction of dsb corresponds to a nonlinear fraction of extracted DNA with dose. , 1990, International journal of radiation biology.

[50]  Anders Brahme,et al.  Treatment Optimization Using Physical and Radiobiological Objective Functions , 1995 .

[51]  William R. Fair,et al.  DOSE ESCALATION WITH THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY AFFECTS THE OUTCOME IN PROSTATE CANCER , 1998 .

[52]  D T Goodhead,et al.  Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. , 1994, International journal of radiation biology.

[53]  L. Gras,et al.  Estimation of the incidence of late bladder and rectum complications after high-dose (70-78 GY) conformal radiotherapy for prostate cancer, using dose-volume histograms. , 1998, International journal of radiation oncology, biology, physics.

[54]  M. Benassi,et al.  An empirical formula, continuous in field parameters and depth, for the axial dose for 60Co gamma radiation , 1972 .

[55]  R. Kauppinen,et al.  1H NMR visible lipids in the life and death of cells. , 2000, Trends in biochemical sciences.

[56]  J. Gore,et al.  Measurement of radiation dose distributions by nuclear magnetic resonance (NMR) imaging. , 1984, Physics in medicine and biology.

[57]  Lynn J. Verhey,et al.  Performance Specifications for Proton Medical Facility , 1993 .

[58]  L E Olsson,et al.  Ferrous sulphate gels for determination of absorbed dose distributions using MRI technique: basic studies. , 1989, Physics in medicine and biology.

[59]  P Chauvel,et al.  Changes in biological effectiveness with depth of the Medicyc neutron therapy beam. , 1996, Bulletin du cancer. Radiotherapie : journal de la Societe francaise du cancer : organe de la societe francaise de radiotherapie oncologique.

[60]  R. Mortimer,et al.  A quantitative model of DNA fragments generated by ionizing radiation, and possible experimental applications. , 1991, Radiation research.

[61]  H Paganetti,et al.  Calculation of relative biological effectiveness for proton beams using biological weighting functions. , 1997, International journal of radiation oncology, biology, physics.

[62]  A Brahme,et al.  Tumour and normal tissue responses to fractionated non-uniform dose delivery. , 1992, International journal of radiation biology.

[63]  M Goitein,et al.  A pencil beam algorithm for proton dose calculations. , 1996, Physics in medicine and biology.

[64]  B. Collinge,et al.  A Precision Current Integrator of Medium Sensitivity , 1953 .

[65]  A Piermattei,et al.  Characteristics of silicon and diamond detectors in a 60 MeV proton beam. , 2002, Physics in medicine and biology.

[66]  H. J. Brede,et al.  Induction of DNA double-strand breaks by 1H and 4He lons in primary human skin fibroblasts in the LET range of 8 to 124 keV/microm. , 1999, Radiation research.

[67]  A. Buttafava,et al.  ESR study of radical processes in irradiated DNA: The effect of the complexation with cis-dichloro diamino Pt(II) , 1996 .

[68]  Marco Zaider,et al.  Microdosimetry and Its Applications , 1995 .

[69]  F. H. Attix Introduction to Radiological Physics and Radiation Dosimetry , 1991 .

[70]  C Brovall,et al.  Radiation sensitivity of human natural killer cell activity: control by X-linked genes. , 1981, Journal of immunology.

[71]  J. Galvin,et al.  Radiochromic film dosimetry: recommendations of AAPM Radiation Therapy Committee Task Group 55. American Association of Physicists in Medicine. , 1998, Medical physics.

[72]  A Ottolenghi,et al.  The FLUKA code for space applications: recent developments. , 2004, Advances in space research : the official journal of the Committee on Space Research.

[73]  E. Hersh,et al.  Gamma-irradiated peripheral blood mononuclear cells can express LAK activity. , 1991, International journal of cell cloning.

[74]  P. Umapathy,et al.  The chemical and biochemical consequences of the binding of the antitumour drug cisplatin and other platinum group metal complexes to DNA , 1989 .

[75]  C. Mothersill,et al.  Lethal mutations and genomic instability. , 1997, International journal of radiation biology.

[76]  C C Ling,et al.  Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality. , 2000, International journal of radiation oncology, biology, physics.

[77]  Reinhard W. Schulte,et al.  Conformal proton therapy for prostate carcinoma. , 1998, International journal of radiation oncology, biology, physics.

[78]  K Ando,et al.  Chromosome aberration frequencies produced by a 70-MeV proton beam. , 1990, Radiation research.

[79]  Maria Antonella Tabocchini,et al.  Inactivation of normal and tumour human cells irradiated with low energy protons. , 2000 .

[80]  Bernd Giese,et al.  On the Mechanism of Long-Range Electron Transfer through DNA. , 1999, Angewandte Chemie.

[81]  Mario Pillon,et al.  Comparison Between Anthropomorphic Mathematical Phantoms Using MCNP and FLUKA Codes , 1996 .

[82]  I I Rosen,et al.  Treatment planning optimization using constrained simulated annealing. , 1991, Physics in medicine and biology.

[83]  J. Lett,et al.  Damage to cellular DNA from particulate radiations, the efficacy of its processing and the radiosensitivity of mammalian cells , 1992, Radiation and environmental biophysics.

[84]  F Ianzini,et al.  Inactivation and mutation induction in V79 cells by low energy protons: re-evaluation of the results at the LNL facility. , 1993, International journal of radiation biology.

[85]  M. G. Sabini,et al.  Radiochromic film dosimetry of a low energy proton beam. , 2000, Medical physics.

[86]  A Ottolenghi,et al.  DNA complex lesions induced by protons and ⋅-particles: track structure characteristics determining linear energy transfer and particle type dependence , 1997, Radiation and environmental biophysics.

[87]  David Flanagan,et al.  Java in a Nutshell , 1996 .

[88]  J. Gore,et al.  Radiation dose distributions in three dimensions from tomographic optical density scanning of polymer gels: II. Optical properties of the BANG polymer gel. , 1996, Physics in medicine and biology.

[89]  Demetri Terzopoulos,et al.  Snakes: Active contour models , 2004, International Journal of Computer Vision.

[90]  M Zaider,et al.  The synergistic effects of different radiations. , 1980, Radiation research.

[91]  A Niemierko,et al.  Random search algorithm (RONSC) for optimization of radiation therapy with both physical and biological end points and constraints. , 1992, International journal of radiation oncology, biology, physics.

[92]  T Kron,et al.  Fast T1 imaging of dual gel samples for diffusion measurements in NMR dosimetry gels. , 1997, Magnetic resonance imaging.

[93]  Angelo Piermattei,et al.  Preliminary results in solid state dosimetry of proton beams for ocular pathology treatment , 1995 .

[94]  M. Goitein,et al.  Tolerance of normal tissue to therapeutic irradiation. , 1991, International journal of radiation oncology, biology, physics.

[95]  Stephen M. Moore,et al.  DICOM shareware: a public implementation of the DICOM standard , 1994, Medical Imaging.

[96]  Francesco D'errico,et al.  MR images of Fricke-agarose dosimeters irradiated with proton beams , 1999 .

[97]  D. Rideout,et al.  1H NMR visible lipids are induced by phosphonium salts and 5‐fluorouracil in human breast cancer cells , 2001, Magnetic resonance in medicine.

[98]  M. Goitein,et al.  Fitting of normal tissue tolerance data to an analytic function. , 1991, International journal of radiation oncology, biology, physics.

[99]  A Piermattei,et al.  PTW-diamond detector: dose rate and particle type dependence. , 2000, Medical physics.

[100]  C Nauraye,et al.  Experimental determination and verification of the parameters used in a proton pencil beam algorithm. , 2001, Medical physics.

[101]  V Grégoire,et al.  Measurements of radiobiological effectiveness in the 85 MeV proton beam produced at the cyclotron CYCLONE of Louvain-la-Neuve, Belgium. , 1996, Radiation research.

[102]  Aloke Chatterjee,et al.  Clusters of DNA Damage Induced by Ionizing Radiation: Formation of Short DNA Fragments. I. Theoretical Modeling , 1996 .

[103]  A Ottolenghi,et al.  Radiation pneumonitis after breast cancer irradiation: analysis of the complication probability using the relative seriality model. , 2000, International journal of radiation oncology, biology, physics.

[104]  M. Zankl,et al.  The adult male voxel model ”Golem” segmented from whole-body CT patient data , 2001, Radiation and environmental biophysics.

[105]  Jerry L Prince,et al.  Current methods in medical image segmentation. , 2000, Annual review of biomedical engineering.

[106]  S. Spirou,et al.  A gradient inverse planning algorithm with dose-volume constraints. , 1998, Medical physics.

[107]  A Ottolenghi,et al.  Modelling chromosomal aberration induction by ionising radiation: the influence of interphase chromosome architecture. , 2001, Advances in space research : the official journal of the Committee on Space Research.

[108]  E. Thorsby,et al.  Long-term changes in natural killer activity after external pelvic radiotherapy. , 1981, International journal of radiation oncology, biology, physics.

[109]  D T Goodhead,et al.  Molecular and cell models of biological effects of heavy ion radiation , 1995, Radiation and environmental biophysics.

[110]  G. Mazza,et al.  Performances of a VLSI wide dynamic range current-to-frequency converter for strip ionization chambers , 1998 .

[111]  R Miralbell,et al.  Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams. , 2000, International journal of radiation oncology, biology, physics.

[112]  Marco Durante,et al.  The quality of DNA double-strand breaks: A Monte Carlo simulation of the end-structure of strand breaks produced by protons and alpha particles , 1995, Radiation and environmental biophysics.

[113]  M. Löbrich,et al.  Non-random distribution of DNA double-strand breaks induced by particle irradiation. , 1996, International journal of radiation biology.

[114]  Dudley T. Goodhead,et al.  1 – Relationship of Microdosimetric Techniques to Applications in Biological Systems , 1987 .

[115]  David Becker,et al.  Radiation damage in DNA , 1994 .

[116]  G Cuttone,et al.  Preliminary results on a dedicated silicon diode detector for proton dosimetry. , 2002, Radiation protection dosimetry.

[117]  P. Matarrese,et al.  1H‐MRS lipid signal modulation and morphological and ultrastructural changes related to tumor cell proliferation , 1999, Magnetic resonance in medicine.

[118]  A Ottolenghi,et al.  Nuclear architecture and radiation induced chromosome aberrations: models and simulations. , 2002, Radiation protection dosimetry.

[119]  P. Shragge,et al.  Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IV. The suppressive effect of normal pregnancy. , 1978, American journal of obstetrics and gynecology.

[120]  M Goitein,et al.  Energy of proton accelerator necessary for treatment of choroidal melanomas. , 1983, International journal of radiation oncology, biology, physics.

[121]  U Amaldi,et al.  Hadrontherapy in the world and the programmes of the TERA Foundation. , 1998, Tumori.

[122]  H. Degani,et al.  Variations in energy and phospholipid metabolism in normal and cancer human mammary epithelial cells. , 1996, Anticancer research.

[123]  Detlef Blöcher,et al.  DNA Double-strand Break Repair Determines the RBE of α-particles , 1988 .

[124]  J Dausset,et al.  Decline of natural killer cell activity in sublethally irradiated mice. , 1978, Journal of the National Cancer Institute.

[125]  C Johannes,et al.  DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutations and oncogenic transformation. , 1992, Mutagenesis.

[126]  I. Lax,et al.  Electron beam dose planning using discrete Gaussian beams. Mathematical background. , 1981, Acta radiologica. Oncology.

[127]  R Miralbell,et al.  Potential role of intensity modulated proton beams in prostate cancer radiotherapy. , 2001, International journal of radiation oncology, biology, physics.

[128]  Roberto Cherubini,et al.  Radiation effects on soluble metabolites in cultured HeLa cells examined by 1H MRS: Changes in concentration of glutathione and of lipid catabolites induced by gamma rays and proton beams , 2001, International journal of cancer.

[129]  G. Tornielli,et al.  Microdosimetric measurements of the Nice therapeutic proton beam , 2001 .

[130]  Wioletta Wieszczycka,et al.  PHYSICAL AND RADIOBIOLOGICAL PROPERTIES OF HADRONS , 2001 .

[131]  M. Ratner,et al.  Charge hopping in DNA. , 2001, Journal of the American Chemical Society.

[132]  S Marzi,et al.  Optimization of intensity modulated radiation therapy: assessing the complexity of the problem. , 2001, Annali dell'Istituto superiore di sanita.

[133]  Michael Unser,et al.  Splines: a perfect fit for signal and image processing , 1999, IEEE Signal Process. Mag..

[134]  IT Istituto Superiore di Sanit,et al.  HeLa cells after gamma and proton irradiation: 1H MRS studies on lipid and perchloric acid extracts , 1998 .

[135]  A Ottolenghi,et al.  A Monte Carlo calculation of cell inactivation by light ions. , 1997, International journal of radiation biology.

[136]  A. Nahum,et al.  Condensed-history Monte-Carlo simulation for charged particles: what can it do for us? , 1999, Radiation and environmental biophysics.

[137]  U Oelfke,et al.  Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay. , 1996, Radiation research.

[138]  S. Vatnitsky,et al.  Radiochromic film dosimetry for clinical proton beams. , 1997, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[139]  S Webb,et al.  A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density. , 1993, Physics in medicine and biology.

[140]  M. Vitale,et al.  Radiosensitivity of human natural killer cells: binding and cytotoxic activities of natural killer cell subsets. , 1990, Radiation research.

[141]  Bo Nordell,et al.  Diffusion of ferric ions in agarose dosimeter gels , 1992 .

[142]  H. Bartelink,et al.  Potential of radiation-induced chromosome aberrations to predict radiosensitivity in human tumour cells. , 1999, International journal of radiation biology.

[143]  J C Gore,et al.  Dose-response curves for Fricke-infused agarose gels as obtained by nuclear magnetic resonance. , 1990, Physics in medicine and biology.

[144]  B. Perussia,et al.  Lymphokine-activated killer cells, natural killer cells and cytokines. , 1991, Current opinion in immunology.

[145]  M Moyers,et al.  Application of solid state detectors for dosimetry of therapeutic proton beams. , 1995, Medical physics.

[146]  Demetri Terzopoulos,et al.  Deformable models in medical image analysis: a survey , 1996, Medical Image Anal..

[147]  David Becker,et al.  The chemical consequences of radiation damage to DNA , 1993 .

[148]  Timothy E. Schultheiss,et al.  Radiation Dose-Response Models , 1995 .

[149]  T. Böhringer,et al.  Results of proton radiotherapy for uveal melanomas. , 1997, Frontiers of radiation therapy and oncology.

[150]  M. Durante,et al.  A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. , 1998, International journal of radiation biology.

[151]  A. Lomax,et al.  Intensity modulation methods for proton radiotherapy. , 1999, Physics in medicine and biology.

[152]  Franca Podo,et al.  Cellular Localization and Functional Role of Phosphatidylcholine-Specific Phospholipase C in NK Cells , 2001, The Journal of Immunology.

[153]  A M Kellerer,et al.  The relative biological effectiveness of 160 MeV protons--II. Biological data and their interpretation in terms of microdosimetry. , 1978, International journal of radiation oncology, biology, physics.

[154]  A. Mazal,et al.  Radiobiological Effectiveness of Radiation Beams With Broad Let Spectra - Microdosimetric Analysis Using Biological Weighting Functions , 1994 .

[155]  Armando Buttafava,et al.  The electron spin resonance spectrum of γ-irradiated deoxyribonucleic acid: a novel interpretation based on molecular orbital calculations and computer simulations , 1985 .

[156]  J. Gore,et al.  NMR relaxation enhancement in gels polymerized and cross-linked by ionizing radiation: a new approach to 3D dosimetry by MRI. , 1993, Magnetic resonance imaging.

[157]  P Marzola,et al.  Bayesian estimation of relaxation times T(1) in MR images of irradiated Fricke-agarose gels. , 2000, Magnetic resonance imaging.

[158]  A Skretting,et al.  Measurement of the ferric diffusion coefficient in agarose and gelatine gels by utilization of the evolution of a radiation induced edge as reflected in relaxation rate images. , 1997, Physics in medicine and biology.

[159]  R. Mohan,et al.  Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations. , 1991, International journal of radiation oncology, biology, physics.

[160]  N Suchowerska,et al.  Perturbation of radiotherapy beams by radiographic film: measurements and Monte Carlo simulations. , 1999, Physics in medicine and biology.

[161]  R. Cherubini,et al.  ESR study of the chemical damage in the direct radiolysis of DNA by 60Co gamma and 5.6 Mev protons: the effect of the mono and bifunctional complexation to Pt(II) , 1999 .

[162]  J M Slater,et al.  Dosimetry techniques for narrow proton beam radiosurgery. , 1999, Physics in medicine and biology.

[163]  R Goodall,et al.  The 62 MeV proton beam for the treatment of ocular melanoma at Clatterbridge. , 1993, The British journal of radiology.

[164]  P. Kliauga,et al.  Measurement of Single Event Energy Deposition Spectra at 5 nm to 250 nm Simulated Site Sizes , 1990 .

[165]  S. Webb Optimizing the planning of intensity-modulated radiotherapy. , 1994, Physics in medicine and biology.

[166]  S. Rustgi,et al.  Dosimetric characterization of radiosurgical beams with a diamond detector. , 1995, Medical physics.

[167]  J C Gore,et al.  Radiation therapy dosimetry using magnetic resonance imaging of polymer gels. , 1996, Medical physics.

[168]  A Ottolenghi,et al.  Estimating mixed field effects: an application supporting the lack of a non-linear component for chromosome aberration induction by neutrons. , 2003, Radiation protection dosimetry.

[169]  M. Koizumi,et al.  Comparison of radiobiological effective depths in 65-MeV modulated proton beams. , 1997, British Journal of Cancer.

[170]  F D'Errico,et al.  Dose distribution of proton beams with NMR measurements of Fricke-agarose gels. , 1997, Magnetic resonance imaging.

[171]  Masakatsu Imamura,et al.  Identification of lymphocyte subpopulations in human breast cancer tissue and its significance: An immunoperoxidase study with anti‐human t‐ and b‐cell sera , 1982 .

[172]  G. Moschini,et al.  DNA DSB induction and rejoining in V79 cells irradiated with light ions: a constant field gel electrophoresis study. , 2000, International journal of radiation biology.

[173]  A Ottolenghi,et al.  Chromosome aberrations induced by light ions: Monte Carlo simulations based on a mechanistic model. , 1999, International journal of radiation biology.

[174]  M Pugliese,et al.  Inactivation of C3H 10T1/2 cells by monoenergetic high LET alpha-particles. , 1992, International journal of radiation biology.

[175]  F Ianzini,et al.  DNA double-strand breaks induced by low energy protons in V79 cells. , 1994, International journal of radiation biology.

[176]  A. Campa,et al.  A semi-empirical approach to the evaluation of the relative biological effectiveness of therapeutic proton beams: the methodological framework. , 1997, Radiation research.

[177]  J. Little,et al.  Radiobiological studies of a high‐energy modulated proton beam utilizing cultured mammalian cells , 1975 .

[178]  G S Ibbott,et al.  Dosimetric characteristics of an improved radiochromic film. , 1996, Medical physics.

[179]  W A Beckham,et al.  Dose rate dependence of a PTW diamond detector in the dosimetry of a 6 MV photon beam. , 1994, Physics in medicine and biology.

[180]  A Ottolenghi,et al.  Chromosome aberrations as biomarkers of radiation exposure: modelling basic mechanisms. , 2003, Advances in space research : the official journal of the Committee on Space Research.

[181]  A. Niemierko Reporting and analyzing dose distributions: a concept of equivalent uniform dose. , 1997, Medical physics.

[182]  F Ballarini,et al.  Stochastic aspects and uncertainties in the prechemical and chemical stages of electron tracks in liquid water: a quantitative analysis based on Monte Carlo simulations , 2000, Radiation and environmental biophysics.

[183]  F Ballarini,et al.  Modelling radiation-induced biological lesions: from initial energy depositions to chromosome aberrations , 1999, Radiation and environmental biophysics.

[184]  J. Little,et al.  Radiation-induced genomic instability. , 1998, International journal of radiation biology.

[185]  Roberto Cirio,et al.  A VLSI analog pipeline read-out for electrode segmented ionization chambers ☆ , 1999 .

[186]  Jerry L Prince,et al.  Image Segmentation Using Deformable Models , 2000 .

[187]  S A Bäck,et al.  Ferrous sulphate gel dosimetry and MRI for proton beam dose measurements. , 1999, Physics in medicine and biology.

[188]  G. Trinchieri,et al.  Biology of Natural Killer Cells , 1989, Advances in Immunology.

[189]  A. Lomax,et al.  A comparison of dose distributions of proton and photon beams in stereotactic conformal radiotherapy of brain lesions. , 2001, International journal of radiation oncology, biology, physics.

[190]  A Brahme,et al.  Electron Beam Dose Planning Using Discrete Gaussian Beams. , 1982 .

[191]  Demetri Terzopoulos,et al.  Topologically adaptable snakes , 1995, Proceedings of IEEE International Conference on Computer Vision.

[192]  E Grusell,et al.  Relative biological effectiveness of intermediate energy protons. Comparisons with 60Co gamma-radiation using two cell lines. , 1993, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[193]  D. Zarcone,et al.  Radiation sensitivity of resting and activated nonspecific cytotoxic cells of T lineage and NK lineage. , 1989, Blood.

[194]  Mark Rijpkema,et al.  Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels. , 2002, Academic radiology.

[195]  A Brahme,et al.  Comparison of cell survival models for mixed LET radiation. , 1999, International journal of radiation biology.