Digital nerve injuries: a review of predictors of sensory recovery after microsurgical digital nerve repair

BackgroundOptimal surgical management of digital nerve lesions remains uncertain despite the publication of numerous studies. The purposes of this review were primarily to analyze whether there is a superior surgical technique for digital nerve repair and secondarily to statistically verify the variables to be predictors of sensory recovery.MethodsA literature search was performed using PubMed including citation from MEDLINE. Studies were included if they involved patients with digital nerve lacerations in whom end-to-end neurorrhaphy, nerve grafts, conduits, or end-to-side neurorrhaphy were performed. Further, the sensory outcome had to be assessed according to the modified American Society for Surgery of the Hand guidelines to stratify for two-point discrimination in millimeters. The variables age, follow-up, delay in repair, type of trauma, and gap length were extracted. The association between each predictor and response was assessed using a linear mixed model and corrected for heterogeneity between studies. Significance was considered present at p ≤ 0.05.ResultsOf the 34 articles found, 14 articles were included giving appropriate individual data for 191 nerves. There was no statistically significant difference in outcome between operation techniques. Age and follow-up were verified predictors of sensory recovery.ConclusionIn this review, the type of operation for digital nerve repair does not influence sensory outcome. However, we verified outcome to be influenced by the patient’s age and the follow-up period. To add more scientific evidence to our results, larger cohort prospective studies need to be done with better detailed description of data.

[1]  H. Kleinert,et al.  AMERICAN Society for Surgery of the hand. , 1977, The Journal of bone and joint surgery. American volume.

[2]  E. Moberg Criticism and studvy of methods for examining sensibility in the hand* , 1962, Neurology.

[3]  P W Brown,et al.  Factors influencing the success of the surgical repair of peripheral nerves. , 1972, The Surgical clinics of North America.

[4]  N. Poppen,et al.  Recovery of sensibility after suture of digital nerves. , 1979, The Journal of hand surgery.

[5]  J. Chong,et al.  Recovery of sensibility after suture of digital nerves , 1980 .

[6]  D. Green,et al.  Operative hand surgery , 1983 .

[7]  J. Kaas,et al.  The reorganization of somatosensory cortex following peripheral nerve damage in adult and developing mammals. , 1983, Annual review of neuroscience.

[8]  H. Millesi,et al.  Nerve grafting. , 1984, Clinics in plastic surgery.

[9]  Y. Hirasawa,et al.  Evaluation of sensibility after sensory reconstruction of the thumb. , 1985, The Journal of bone and joint surgery. British volume.

[10]  D. Sullivan Results of Digital Neurorrhaphy in Adults , 1985, Journal of hand surgery.

[11]  A L Dellon,et al.  Reliability of two-point discrimination measurements. , 1987, The Journal of hand surgery.

[12]  J. Gattuso,et al.  Peripheral nerve repair in humans using muscle autografts. A new technique. , 1988, The Journal of bone and joint surgery. British volume.

[13]  J. Nunley,et al.  Use of the anterior branch of the medial antebrachial cutaneous nerve as a graft for the repair of defects of the digital nerve. , 1989, The Journal of bone and joint surgery. American volume.

[14]  R. L. Walton,et al.  Autogenous vein graft repair of digital nerve defects in the finger: a retrospective clinical study. , 1989, Plastic and reconstructive surgery.

[15]  A. Berger,et al.  Results of primary nerve repair in the upper extremity , 1989, Microsurgery.

[16]  S. Mackinnon,et al.  A Study of Nerve Regeneration Across Synthetic (Maxon) and Biologic (Collagen) Nerve Conduits For Nerve Gaps Up to 5 Cm in the Primate , 1990, Journal of reconstructive microsurgery.

[17]  Assh The Hand: Examination and Diagnosis , 1990 .

[18]  R. Griffiths Peripheral nerve repair in humans using muscle autografts , 1990 .

[19]  B Strauch,et al.  A prospective clinical evaluation of autogenous vein grafts used as a nerve conduit for distal sensory nerve defects of 3 cm or less. , 1990, Plastic and reconstructive surgery.

[20]  R. Gelberman Operative nerve repair and reconstruction , 1991 .

[21]  A Azzarà,et al.  Results of Primary Repair of Digital Nerves , 1991, Journal of hand surgery.

[22]  J. C. Trindade,et al.  Latero-terminal neurorrhaphy without removal of the epineural sheath. Experimental study in rats. , 1992, Revista paulista de medicina.

[23]  R. Birch,et al.  The Long Term Result of Digital Nerve Repair in No-Man’s Land , 1992, Journal of hand surgery.

[24]  M. Vastamäki,et al.  An Analysis of the Results of Late Reconstruction of 132 Median Nerves , 1993, Journal of hand surgery.

[25]  Y. Gu,et al.  Repair of Digital Nerve Defect with Autogenous Vein Graft during Flexor Tendon Surgery in Zone 2 , 1993, Journal of hand surgery.

[26]  P. Kallio The Results of Secondary Repair of 254 Digital Nerves , 1993, Journal of hand surgery.

[27]  K. Khan,et al.  Results of Clinical Assessment after Primary Digital Nerve Repair , 1994, Journal of hand surgery.

[28]  A. Mazzoni,et al.  Two end-to-side neurorrhaphies and nerve graft with removal of the epineural sheath: experimental study in rats. , 1994, British journal of plastic surgery.

[29]  D. Efstathopoulos,et al.  Clinical assessment of primary digital nerve repair. , 1995, Acta orthopaedica Scandinavica. Supplementum.

[30]  H. Tadjalli,et al.  Digital Nerve Repair: Relationship Between Severity of Injury and Sensibility Recovery , 1995, Annals of plastic surgery.

[31]  J B Tang,et al.  Vein Conduits with Interposition of Nerve Tissue for Peripheral Nerve Defects , 1995, Journal of reconstructive microsurgery.

[32]  D L Sackett,et al.  Clinical recommendations using levels of evidence for antithrombotic agents. , 1995, Chest.

[33]  J. Nunley,et al.  Results of interfascicular nerve grafting for radial nerve lesions , 1996, Microsurgery.

[34]  W. Baylis,et al.  Outcome of digital nerve injuries in adults. , 1996, The Journal of hand surgery.

[35]  M. Boyer Green's Operative Hand Surgery, 4th ed , 1999 .

[36]  S. Wolfe,et al.  Peripheral Nerve Injury and Repair , 2000, The Journal of the American Academy of Orthopaedic Surgeons.

[37]  B Strauch,et al.  Use of nerve conduits in peripheral nerve repair. , 2000, Hand clinics.

[38]  N. Weinzweig,et al.  Recovery of Sensibility After Digital Neurorrhaphy: A Clinical Investigation of Prognostic Factors , 2000, Annals of plastic surgery.

[39]  R. Weber,et al.  A Randomized Prospective Study of Polyglycolic Acid Conduits for Digital Nerve Reconstruction in Humans , 2000, Plastic and reconstructive surgery.

[40]  M. Al-Qattan Terminolateral Neurorrhaphy: Review of Experimental and Clinical Studies , 2001, Journal of reconstructive microsurgery.

[41]  K A Segalman,et al.  Digital Neurorrhaphy after the Age of 60 Years , 2001, Journal of reconstructive microsurgery.

[42]  V. Casoli,et al.  [Terminal-lateral nerve anastomoses. Preliminary clinical report of two cases]. , 2001, Annales de chirurgie plastique et esthetique.

[43]  L. Hung,et al.  A Prospective Study of Early Tactile Stimulation After Digital Nerve Repair , 2001, Clinical orthopaedics and related research.

[44]  D. Martin,et al.  Les anastomoses nerveuses terminolatrales. Rapport clinique prliminaire propos de dix cas , 2001 .

[45]  al-Qattan Mm Terminolateral neurorrhaphy: review of experimental and clinical studies. , 2001 .

[46]  M. Meek,et al.  Clinical Use of Nerve Conduits in Peripheral-Nerve Repair: Review of the Literature , 2002, Journal of reconstructive microsurgery.

[47]  S. Coppolino,et al.  Clinical results and thoughts on sensory nerve repair by autologous vein graft in emergency hand reconstruction. , 2002, Chirurgie de la main.

[48]  M. Frey,et al.  End-to-side neurorrhaphy of sensory nerves , 2003, European Journal of Plastic Surgery.

[49]  M. Frey Commentary on "The use of silicone tubes in end-to-side nerve grafting: an experimental study" by Gravvanis et al. , 2003, European Journal of Plastic Surgery.

[50]  U. Mennen End-to-side nerve suture in clinical practice. , 2003, Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand.

[51]  Stephen Lemos,et al.  A New Technique , 2004, The American journal of sports medicine.

[52]  Stefano Geuna,et al.  Nerve repair by means of tubulization: Literature review and personal clinical experience comparing biological and synthetic conduits for sensory nerve repair , 2005, Microsurgery.

[53]  C. Rohde,et al.  Pathway sampling by regenerating peripheral axons , 2005, The Journal of comparative neurology.

[54]  M. Meek,et al.  Poor results after nerve grafting in the upper extremity: Quo vadis? , 2005, Microsurgery.

[55]  P. Mailänder,et al.  Advances in peripheral nerve repair in emergency surgery of the hand , 1991, World Journal of Surgery.

[56]  O. Chan,et al.  Hand , 2005, BMJ : British Medical Journal.

[57]  R. Buntic End-to-Side Neurorrhaphy for Defects of Palmar Sensory Digital Nerves , 2006 .

[58]  F. Doglietto,et al.  End-to-side nerve neurorrhaphy: critical appraisal of experimental and clinical data. , 2007, Acta neurochirurgica. Supplement.

[59]  P. Tos,et al.  Alternative techniques for peripheral nerve repair: conduits and end-to-side neurorrhaphy. , 2007, Acta neurochirurgica. Supplement.

[60]  G Lundborg,et al.  Hand function after nerve repair , 2007, Acta physiologica.

[61]  S. Shieh,et al.  Secondary nerve reconstruction using vein conduit grafts for neglected digital nerve injuries , 2008, Microsurgery.

[62]  P. Soucacos,et al.  Nerve repair: experimental and clinical evaluation of biodegradable artificial nerve guides. , 2008, Injury.

[63]  Brandon D Bushnell,et al.  Early clinical experience with collagen nerve tubes in digital nerve repair. , 2008, The Journal of hand surgery.

[64]  Hans-Günther Machens,et al.  The clinical use of artificial nerve conduits for digital nerve repair: a prospective cohort study and literature review. , 2009, Journal of reconstructive microsurgery.

[65]  P. Tos,et al.  Termino-lateral nerve suture in lesions of the digital nerves: clinical experience and literature review , 2010, The Journal of hand surgery, European volume.

[66]  Marcoccio Ignazio,et al.  Muscle-in-Vein Nerve Guide for Secondary Reconstruction in Digital Nerve Lesions , 2010 .

[67]  I. Marcoccio,et al.  Muscle-in-vein nerve guide for secondary reconstruction in digital nerve lesions. , 2010, The Journal of hand surgery.

[68]  B. Rinker,et al.  A prospective randomized study comparing woven polyglycolic acid and autogenous vein conduits for reconstruction of digital nerve gaps. , 2009, The Journal of hand surgery.