Origin of Stem Cells in Organogenesis

The development of individual organs in animal embryos involves the formation of tissue-specific stem cells that sustain cell renewal of their own tissue for the lifetime of the organism. Although details of their origin are not always known, tissue-specific stem cells usually share the expression of key transcription factors with cells of the embryonic rudiment from which they arise, and are probably in a similar developmental state. On the other hand, the isolation of pluripotent stem cells from the postnatal organism has encouraged the formulation of models of embryonic and postnatal development that are at variance with the conventional ones. Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed.

[1]  P. Traber,et al.  Cdx1 and cdx2 expression during intestinal development. , 2000, Gastroenterology.

[2]  Irving L Weissman,et al.  Biology of hematopoietic stem cells and progenitors: implications for clinical application. , 2003, Annual review of immunology.

[3]  L. Pevny,et al.  SOX2 Functions to Maintain Neural Progenitor Identity , 2003, Neuron.

[4]  Yann Barrandon,et al.  Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells , 2001, Cell.

[5]  L. Zon,et al.  Hematopoiesis: An Evolving Paradigm for Stem Cell Biology , 2008, Cell.

[6]  Anthony Atala,et al.  Isolation of amniotic stem cell lines with potential for therapy , 2007, Nature Biotechnology.

[7]  E. Fuchs,et al.  Hair follicle stem cells are specified and function in early skin morphogenesis. , 2008, Cell stem cell.

[8]  Andrea-Romana Prusa,et al.  Oct-4-expressing cells in human amniotic fluid: a new source for stem cell research? , 2003, Human reproduction.

[9]  David J. Anderson,et al.  Prospective Identification, Isolation by Flow Cytometry, and In Vivo Self-Renewal of Multipotent Mammalian Neural Crest Stem Cells , 1999, Cell.

[10]  S. Fraser,et al.  Vital dye labelling of Xenopus laevis trunk neural crest reveals multipotency and novel pathways of migration. , 1993, Development.

[11]  A. Schäffler,et al.  Concise Review: Adipose Tissue‐Derived Stromal Cells—Basic and Clinical Implications for Novel Cell‐Based Therapies , 2007, Stem cells.

[12]  M. Weiss,et al.  Concise Review: Wharton's Jelly‐Derived Cells Are a Primitive Stromal Cell Population , 2008, Stem cells.

[13]  J. Sanes,et al.  Lineage of neurons and glia in chick dorsal root ganglia: analysis in vivo with a recombinant retrovirus. , 1991, Development.

[14]  J. Sanes.  Analysing cell lineage with a recombinant retrovirus , 1989, Trends in Neurosciences.

[15]  H. Niemann,et al.  Isolation of Murine and Porcine Fetal Stem Cells from Somatic Tissue1 , 2005, Biology of reproduction.

[16]  David R. Kaplan,et al.  A dermal niche for multipotent adult skin-derived precursor cells , 2004, Nature Cell Biology.

[17]  David J. Anderson,et al.  Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members , 1996, Cell.

[18]  L. Looijenga,et al.  Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives. , 2007, International journal of andrology.

[19]  R. A. Willis.  The Borderland of Embryology and Pathology , 1950, Bulletin of the New York Academy of Medicine.

[20]  Elaine Fuchs,et al.  Epidermal stem cells of the skin. , 2006, Annual review of cell and developmental biology.

[21]  F. Miller,et al.  Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[22]  D. Zipori,et al.  The Stem State: Plasticity Is Essential, Whereas Self‐Renewal and Hierarchy Are Optional , 2005, Stem cells.

[23]  D. Harrison.  Normal production of erythrocytes by mouse marrow continuous for 73 months. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[24]  D. Ponzin,et al.  p63 identifies keratinocyte stem cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[25]  J Ratajczak,et al.  Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells , 2005, Leukemia.

[26]  T. Shimazaki,et al.  Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart , 2005, The Journal of cell biology.

[27]  A. Joyner,et al.  Genetic inducible fate mapping in mouse: Establishing genetic lineages and defining genetic neuroanatomy in the nervous system , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[28]  N. Nardi,et al.  In Search of the In Vivo Identity of Mesenchymal Stem Cells , 2008, Stem cells.

[29]  R. Stewart,et al.  Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells , 2007, Science.

[30]  M Grim,et al.  Pluripotent neural crest stem cells in the adult hair follicle , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[31]  H. Blau,et al.  The Evolving Concept of a Stem Cell Entity or Function? , 2001, Cell.

[32]  C. Matheny,et al.  Runx1 Is Expressed in Adult Mouse Hematopoietic Stem Cells and Differentiating Myeloid and Lymphoid Cells, But Not in Maturing Erythroid Cells , 2004, Stem cells.

[33]  P. Scotting.  Are cranial germ cell tumours really tumours of germ cells? , 2006, Neuropathology and applied neurobiology.

[34]  G. Fishell,et al.  Genetic approaches identify adult pituitary stem cells , 2008, Proceedings of the National Academy of Sciences.

[35]  Catherine M. Verfaillie,et al.  Pluripotency of mesenchymal stem cells derived from adult marrow , 2002, Nature.

[36]  S. Fraser,et al.  Cell lineage analysis reveals multipotency of some avian neural crest cells , 1988, Nature.

[37]  A. Mills,et al.  p63 is the molecular switch for initiation of an epithelial stratification program. , 2004, Genes & development.

[38]  P. L. Krohn.  Review Lectures on Senescence - II. Heterochronic transplantation in the study of ageing , 1962, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[39]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[40]  M. Grompe,et al.  Cell fusion is the principal source of bone-marrow-derived hepatocytes , 2003, Nature.

[41]  P. Morrison,et al.  Pluripotent Stem Cells Identified in Multiple Murine Tissues , 2003, Annals of the New York Academy of Sciences.

[42]  C. Cepko,et al.  Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[43]  A. McMahon,et al.  Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. , 2000, Development.

[44]  S. Morrison,et al.  Neural Crest Stem Cells Persist in the Adult Gut but Undergo Changes in Self-Renewal, Neuronal Subtype Potential, and Factor Responsiveness , 2002, Neuron.

[45]  P. Schiller,et al.  Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential , 2004, Journal of Cell Science.

[46]  R. M. Wynn.  The borderland of embryology and pathology , 1964 .

[47]  V. Episkopou.  SOX2 functions in adult neural stem cells , 2005, Trends in Neurosciences.

[48]  M. Grompe,et al.  Generation and Regeneration of Cells of the Liver and Pancreas , 2008, Science.

[49]  Helen M. Blau,et al.  Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant , 2003, Nature Cell Biology.

[50]  Irving L Weissman,et al.  Plasticity of Adult Stem Cells , 2004, Cell.

[51]  J. Slack.  Homoeotic transformations in man: implications for the mechanism of embryonic development and for the organization of epithelia. , 1985, Journal of theoretical biology.

[52]  S. Nishikawa,et al.  Neuroepithelial Cells Supply an Initial Transient Wave of MSC Differentiation , 2007, Cell.

[53]  Toshio Miki,et al.  Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells , 2008, Stem cells.

[54]  L. Lajtha.  Stem cell concepts. , 1979, Nouvelle revue francaise d'hematologie.

[55]  Hans Clevers,et al.  The intestinal stem cell. , 2008, Genes & development.