High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes

[1]  M. Farzaei,et al.  Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective , 2018, Nutrients.

[2]  A. Whitworth,et al.  The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease. , 2018, Cell reports.

[3]  Kang-Yell Choi,et al.  Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling , 2018, Experimental & Molecular Medicine.

[4]  J. Lapointe,et al.  Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction , 2018, World journal of gastroenterology.

[5]  Songtao Li,et al.  Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease , 2018, Experimental & Molecular Medicine.

[6]  Ikenna C. Eze,et al.  Insufficient Fruit and Vegetable Intake in a Low- and Middle-Income Setting: A Population-Based Survey in Semi-Urban Tanzania , 2018, Nutrients.

[7]  M. Myers,et al.  Leptin and the maintenance of elevated body weight , 2018, Nature Reviews Neuroscience.

[8]  M. Cruz,et al.  Nicotinamide prevents sweet beverage‐induced hepatic steatosis in rats by regulating the G6PD, NADPH/NADP+ and GSH/GSSG ratios and reducing oxidative and inflammatory stress , 2018, European journal of pharmacology.

[9]  H. Tilg,et al.  Fat-enriched rather than high-fructose diets promote whitening of adipose tissue in a sex-dependent manner. , 2017, The Journal of nutritional biochemistry.

[10]  M. Serlie,et al.  Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease , 2017, Nutrients.

[11]  T. Saibara,et al.  Use of Mac‐2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis , 2017, Hepatology communications.

[12]  G. Piccoli,et al.  The Diet and Haemodialysis Dyad: Three Eras, Four Open Questions and Four Paradoxes. A Narrative Review, Towards a Personalized, Patient-Centered Approach , 2017, Nutrients.

[13]  Xiongwei Xie.  Liquiritigenin attenuates cardiac injury induced by high fructose-feeding through fibrosis and inflammation suppression. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  K. Iizuka.  The Role of Carbohydrate Response Element Binding Protein in Intestinal and Hepatic Fructose Metabolism , 2017, Nutrients.

[15]  Joshua D Rabinowitz,et al.  One-Carbon Metabolism in Health and Disease. , 2017, Cell metabolism.

[16]  A. Molina,et al.  Regulators of Mitochondrial Quality Control Differs in Subcutaneous Fat of Metabolically Healthy and Unhealthy Obese Monkeys , 2016, Obesity.

[17]  K. Kavanagh,et al.  Fatty Liver Promotes Fibrosis In Monkeys Consuming High Fructose , 2016, Obesity.

[18]  M. Herman,et al.  The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis , 2016, Trends in Endocrinology & Metabolism.

[19]  C. Medana,et al.  Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice. , 2016, Free radical biology & medicine.

[20]  L. Redman,et al.  Effect of Two‐Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non‐Obese Younger Adults: A Randomized Clinical Trial , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  R. Mailloux,et al.  Protein S-glutathionlyation links energy metabolism to redox signaling in mitochondria , 2015, Redox biology.

[22]  Chunlin Li,et al.  Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research) , 2015, Journal of diabetes research.

[23]  Ching-Wei Chang,et al.  Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One–Carbon Cycle Energy Producing Pathway , 2015, Metabolites.

[24]  Xiaoming Fan,et al.  Ghrelin-ghrelin O-acyltransferase system in the pathogenesis of nonalcoholic fatty liver disease. , 2015, World journal of gastroenterology.

[25]  S. Caprio,et al.  Blunted suppression of acyl‐ghrelin in response to fructose ingestion in obese adolescents: The role of insulin resistance , 2015, Obesity.

[26]  S. Swoap,et al.  Three Months of High-Fructose Feeding Fails to Induce Excessive Weight Gain or Leptin Resistance in Mice , 2014, PloS one.

[27]  G. Shulman,et al.  Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans , 2014, Proceedings of the National Academy of Sciences.

[28]  T. Shlomi,et al.  Quantitative flux analysis reveals folate-dependent NADPH production , 2014, Nature.

[29]  A. Jobe,et al.  Ventilation-Induced Increases in EGFR Ligand mRNA Are Not Altered by Intra-Amniotic LPS or Ureaplasma in Preterm Lambs , 2014, PloS one.

[30]  J. Auwerx,et al.  Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 , 2014, EMBO molecular medicine.

[31]  G. Matić,et al.  Dietary fructose-related adiposity and glucocorticoid receptor function in visceral adipose tissue of female rats , 2014, European Journal of Nutrition.

[32]  M. Díaz-Flores,et al.  Nicotinamide, a glucose-6-phosphate dehydrogenase non-competitive mixed inhibitor, modifies redox balance and lipid accumulation in 3T3-L1 cells. , 2013, Life sciences.

[33]  S. Verma,et al.  Predictive value of ALT levels for non‐alcoholic steatohepatitis (NASH) and advanced fibrosis in non‐alcoholic fatty liver disease (NAFLD) , 2013, Liver international : official journal of the International Association for the Study of the Liver.

[34]  I. Rusyn,et al.  Strain‐dependent dysregulation of one‐carbon metabolism in male mice is associated with choline‐ and folate‐deficient diet‐induced liver injury , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  G. Matić,et al.  Fructose consumption enhances glucocorticoid action in rat visceral adipose tissue. , 2013, The Journal of nutritional biochemistry.

[36]  M. Başaranoǧlu,et al.  Fructose as a key player in the development of fatty liver disease. , 2013, World journal of gastroenterology.

[37]  V. Lionetti,et al.  Glucose 6-Phosphate Dehydrogenase Deficiency Increases Redox Stress and Moderately Accelerates the Development of Heart Failure , 2013, Circulation. Heart failure.

[38]  Li Tang,et al.  Protective effects of nicotinamide against acetaminophen-induced acute liver injury. , 2012, International immunopharmacology.

[39]  T. Merritt,et al.  Interactions of NADP-Reducing Enzymes Across Varying Environmental Conditions: A Model of Biological Complexity , 2012, G3: Genes | Genomes | Genetics.

[40]  P. Hecker,et al.  Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets. , 2012, American journal of physiology. Endocrinology and metabolism.

[41]  L. Du,et al.  Regulation of adipose differentiation by fructose and GluT5. , 2012, Molecular endocrinology.

[42]  J. Iredale,et al.  Macrophages: central regulators of hepatic fibrogenesis and fibrosis resolution. , 2012, Journal of hepatology.

[43]  S. Watkins,et al.  The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. , 2012, Cell metabolism.

[44]  H. T. Kang,et al.  Nicotinamide-induced Mitophagy , 2012, The Journal of Biological Chemistry.

[45]  D. Cameron-Smith,et al.  Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBP1c with no effect on body weight or liver fat. , 2012, Food & function.

[46]  J. Kieswich,et al.  Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function , 2011, Diabetologia.

[47]  K. Adeli,et al.  Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. , 2010, American journal of physiology. Endocrinology and metabolism.

[48]  Shelly C. Lu,et al.  Fatty liver and fibrosis in glycine N‐methyltransferase knockout mice is prevented by nicotinamide , 2010, Hepatology.

[49]  E. Rogdakis,et al.  Comparative Approach of the de novo Fatty Acid Synthesis (Lipogenesis) between Ruminant and Non Ruminant Mammalian Species: From Biochemical Level to the Main Regulatory Lipogenic Genes , 2010, Current genomics.

[50]  R. Boldrini,et al.  Protein glutathionylation increases in the liver of patients with non‐alcoholic fatty liver disease , 2008, Journal of gastroenterology and hepatology.

[51]  S. Friedman,et al.  Mechanisms of hepatic fibrogenesis. , 2008, Gastroenterology.

[52]  D. Witcher,et al.  Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. , 2008, The Journal of clinical endocrinology and metabolism.

[53]  G. Shulman,et al.  Cytosolic and Mitochondrial Malic Enzyme Isoforms Differentially Control Insulin Secretion* , 2007, Journal of Biological Chemistry.

[54]  U. Flügge,et al.  A Comprehensive Analysis of the NADP-Malic Enzyme Gene Family of Arabidopsis1[w] , 2005, Plant Physiology.

[55]  F. Marra,et al.  Dose dependent and divergent effects of superoxide anion on cell death, proliferation, and migration of activated human hepatic stellate cells , 2005, Gut.

[56]  T. Huh,et al.  Cytosolic NADP+-dependent Isocitrate Dehydrogenase Plays a Key Role in Lipid Metabolism* , 2004, Journal of Biological Chemistry.

[57]  R. Townsend,et al.  Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. , 2004, The Journal of clinical endocrinology and metabolism.

[58]  N. Keim,et al.  Fructose, weight gain, and the insulin resistance syndrome. , 2002, The American journal of clinical nutrition.

[59]  T. Huh,et al.  Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. , 2002, Free radical biology & medicine.

[60]  Freya Q. Schafer,et al.  Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. , 2001, Free radical biology & medicine.

[61]  G. Kroemer,et al.  Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells: correlation with changes in mitochondria, glutathione depletion, intracellular acidification and caspase 3 activation. , 2001, The Biochemical journal.

[62]  K. Lindor,et al.  The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease , 1999, American Journal of Gastroenterology.

[63]  R. Kletzien,et al.  Glucose‐6‐phosphate dehydrogenase: a “housekeeping” enzyme subject to tissue‐specific regulation by hormones, nutrients, and oxidant stress , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[64]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[65]  F. Tietze.  Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. , 1969, Analytical biochemistry.

[66]  F. Booth,et al.  High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. , 2018, American journal of physiology. Endocrinology and metabolism.

[67]  Xiao-Yi Zeng,et al.  IRE1 impairs insulin signaling transduction of fructose-fed mice via JNK independent of excess lipid. , 2015, Biochimica et biophysica acta.

[68]  Won-Young Lee,et al.  Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes. , 2014, The Journal of nutritional biochemistry.

[69]  K. Shibata,et al.  Pharmacological doses of nicotinic acid and nicotinamide are independently metabolized in rats. , 2014, Journal of nutritional science and vitaminology.

[70]  J. Girard,et al.  Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver. , 2012, Journal of hepatology.

[71]  B. Amir-Ahmady,et al.  Dietary regulation of expression of glucose-6-phosphate dehydrogenase. , 2001, Annual review of nutrition.

[72]  P. Fürst,et al.  Improved analysis of malondialdehyde in human body fluids. , 1996, Free radical biology & medicine.