Regional study of the genetic influence on the sulcal pits

The influence of genes on cortical structures has been assessed through various phenotypes already. However, the heritability of the sulcal pits, which are the deepest points of the sulci, has not yet been estimated. These pits are assumed to be under tight genetic control and to have close relationship with underlying functional organization. We estimated the heritability of these pits depth using the HCP pedigree data. Our results confirm previous hypothesis, with significant heritability estimates found for the pits of central and superior temporal sulci, and underline the pit as biomarkers of interest for future genome wide association studies.

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