Mercury Exposure in Children With Autistic Spectrum Disorder: Case-Control Study

Although mercury has been proven to be a neurotoxicant, there is a lack of data to evaluate the causal relationship between mercury and autism. We aim to see if there is increased mercury exposure in children with autistic spectrum disorder. We performed a cross-sectional cohort study over a 5-month period in 2000 to compare the hair and blood mercury levels of children with autistic spectrum disorder (n = 82; mean age 7.2 years) and a control group of normal children (n = 55; mean age 7.8 years). There was no difference in the mean mercury levels. The mean blood mercury levels of the autistic and control groups were 19.53 and 17.68 nmol/L, respectively (P = .15), and the mean hair mercury levels of the autistic and control groups were 2.26 and 2.07 ppm, respectively (P = .79). Thus, the results from our cohort study with similar environmental mercury exposure indicate that there is no causal relationship between mercury as an environmental neurotoxin and autism. (J Child Neurol 2004;19:431-434).

[1]  G. Dawson,et al.  The screening and diagnosis of autistic spectrum disorders. , 2004, Journal of autism and developmental disorders.

[2]  M. Lauritsen,et al.  The genetics of autism , 2001, Acta psychiatrica Scandinavica.

[3]  S. Hyman,et al.  The role of candidate genes in unraveling the genetics of autism , 2000 .

[4]  W. Sexson,et al.  Iatrogenic exposure to mercury after hepatitis B vaccination in preterm infants. , 2000, The Journal of pediatrics.

[5]  Stephen J. Guter,et al.  A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p. , 2001, American journal of human genetics.

[6]  G. Dawson,et al.  Practice parameter: Screening and diagnosis of autism , 2000, Neurology.

[7]  E. Budtz-Jørgensen,et al.  Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. , 2000, The Journal of pediatrics.

[8]  P. Ozuah.  Mercury poisoning. , 2000, Current problems in pediatrics.

[9]  E. Fombonne,et al.  The epidemiology of autism: a review , 1999, Psychological Medicine.

[10]  E. Fombonne.  Is there an epidemic of autism? , 2001, Pediatrics.

[11]  Roberta F. White,et al.  Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. , 1997, Neurotoxicology and teratology.

[12]  C Cox,et al.  Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. , 1998, JAMA.

[13]  R. Tuthill.  Hair lead levels related to children's classroom attention-deficit behavior. , 1996, Archives of environmental health.

[14]  M. Mutanen,et al.  Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. , 1995, Circulation.

[15]  J. Risher,et al.  Mercury, infant neurodevelopment, and vaccination. , 2000, The Journal of pediatrics.