In‐vitro and in‐vivo studies of human axillary odour and the cutaneous microflora

The axillary microflora of 34 male subjects were studied in relation to their underarm odour intensity. The predominant groups of micro‐organisms were aerobic coryneforms, Micrococcaceae and propionibacteria. There was no competition for habitat between these groups (Fishers exact test P <0·05). There was an association between the population density of aerobic coryneforms and the intensity of odour (Spearman P = 0.001). Dominance of aerobic coryneforms within the axillary microflora was associated with high odour intensity (x2, P= 0.005). An in‐vitro odour model was developed using a diethyl ether extract of axillary skin incubated with test bacteria. Underarm odour was produced exclusively by aerobic coryneform bacteria. Of aerobic coryneforms, 71.4% were odour producers and these were identified as Corynebacterium xerosis.

[1]  K. T. Holland,et al.  Applications of gas chromatography-mass spectrometry in the study of androgen and odorous 16-androstene metabolism by human axillary bacteria. , 1991, Journal of chromatography.

[2]  A. Mallet,et al.  The skin microflora and the formation of human axillary odour , 1990, International journal of cosmetic science.

[3]  K. T. Holland,et al.  Interconversion of androst-16-ene steroids by human axillary aerobic coryneform bacteria. , 1989, Biochemical Society transactions.

[4]  A. Mallet,et al.  Simultaneous quantification of five odorous steroids (16-androstenes) in the axillary hair of men. , 1988, Journal of steroid biochemistry.

[5]  A. Mallet,et al.  Testosterone metabolism by pure and mixed cultures of human corynebacteria , 1987 .

[6]  K. T. Holland,et al.  The cutaneous microbiology of normal human feet. , 1987, The Journal of applied bacteriology.

[7]  A. Mallet,et al.  Testosterone metabolism by isolated human axillary Corynebacterium spp.: a gas-chromatographic mass-spectrometric study. , 1986, Journal of steroid biochemistry.

[8]  P. Jackman,et al.  Normal axillary skin in various populations , 1983 .

[9]  P. Jackman,et al.  Normal axillary skin microflora in various populations. , 1983, Clinical and experimental dermatology.

[10]  D. B. Gower,et al.  Axillary 5α-androst-16-en-3-one, cholesterol and squalene in men; Preliminary evidence for 5α-androst-16-en-3-one being a product of bacterial action , 1982 .

[11]  A M Kligman,et al.  The microbiology of the human axilla and its relationship to axillary odor. , 1981, The Journal of investigative dermatology.

[12]  T. Rodgers.  MICROBIOLOGY OF HUMAN SKIN , 1981, The Ulster Medical Journal.

[13]  H. Behrendt,et al.  Patterns of skin pH from birth through adolescence : with a synopsis on skin growth , 1971 .

[14]  A. Kligman,et al.  A new method for the quantitative investigation of cutaneous bacteria. , 1965, The Journal of investigative dermatology.

[15]  A. Kligman,et al.  The effect of topical antibacterial agents on the bacterial flora of the axilla. , 1963, The Journal of investigative dermatology.