3D neuro-electronic interface devices for neuromuscular control: design studies and realisation steps.

In order to design the shape and dimensions of new 3D multi-microelectrode information transducers properly, i.e. adapted to the scale of information delivery to and from peripheral nerve fibres, a number of studies were, and still are, being performed on modelling and simulation of electrical volume conduction inside and outside nerves, on animal experiments on stimulation and recording with single wires and linear arrays, and on new technologies for 3D micro-fabrication. This paper presents a selection of the results of these "Neurotechnology' studies at the University of Twente. The experimental and simulation results apply primarily to the peripheral motor nerves of the rat, but are also of interest for neural interfacing with myelinated nerves in man, as fascicles in man are about the same size as in the rat.

[1]  D. Mcneal.  Analysis of a Model for Excitation of Myelinated Nerve , 1976, IEEE Transactions on Biomedical Engineering.

[2]  R. Stein,et al.  Microneurography for the recording and selective stimulation of afferents: An assessment , 1988, Muscle & nerve.

[3]  David J. Edell,et al.  A Peripheral Nerve Information Transducer for Amputees: Long-Term Multichannel Recordings from Rabbit Peripheral Nerves , 1986, IEEE Transactions on Biomedical Engineering.

[4]  R. Mackel,et al.  Time course of action potentials recorded from single human afferents. , 1993, Brain : a journal of neurology.

[5]  Winfried Mayr,et al.  Multi-channel indirect stimulation reduces muscle fatigue , 1989, Images of the Twenty-First Century. Proceedings of the Annual International Engineering in Medicine and Biology Society,.

[6]  J. H. Meier.  Selectivity and design of neuro-electronic interfaces , 1992 .

[7]  J.H. Meier,et al.  Simulation of multipolar fiber selective neural stimulation using intrafascicular electrodes , 1992, IEEE Transactions on Biomedical Engineering.

[8]  J. M. Peyronnard,et al.  Motor, sympathetic and sensory innervation of rat skeletal muscles , 1986, Brain Research.

[9]  D. McCreery,et al.  Neural prostheses : fundamental studies , 1990 .

[10]  W.L.C. Rutten,et al.  Sensitivity and selectivity of intraneural stimulation using a silicon electrode array , 1991, IEEE Transactions on Biomedical Engineering.

[11]  J. M. Ritchie,et al.  A quantitative description of membrane currents in rabbit myelinated nerve. , 1979, The Journal of physiology.

[12]  R. Close.  Properties of motor units in fast and slow skeletal muscles of the rat , 1967, The Journal of physiology.

[13]  D. A. Ksienski,et al.  A nerve cuff technique for selective excitation of peripheral nerve trunk regions , 1990, IEEE Transactions on Biomedical Engineering.

[14]  Hiroshi Masuhara,et al.  Iridium oxide-based microelectrochemical transistors for pH sensing , 1993 .

[15]  Moshe Solomonow,et al.  Manipulation of Muscle Force with Various Firing Rate and Recruitment Control Strategies , 1987, IEEE Transactions on Biomedical Engineering.

[16]  R. Blanks,et al.  Motoneurons of the rat sciatic nerve , 1986, Experimental Neurology.

[17]  F Rattay,et al.  Ways to approximate current-distance relations for electrically stimulated fibers. , 1987, Journal of theoretical biology.

[18]  P K Thomas,et al.  Composition of Peripheral Nerves , 1969 .