Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

[1]  Wai Lim Ku,et al.  Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila , 2018, Nature Communications.

[2]  Michael E. Greenberg,et al.  Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior , 2018, Neuron.

[3]  K. Fox,et al.  Mechanisms underlying the role of DISC1 in synaptic plasticity , 2018, The Journal of physiology.

[4]  J. Medina,et al.  Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc , 2018, Front. Behav. Neurosci..

[5]  S. Kim,et al.  Synapse development organized by neuronal activity-regulated immediate-early genes , 2018, Experimental & Molecular Medicine.

[6]  S. Abdelhak,et al.  TOP3B: A Novel Candidate Gene in Juvenile Myoclonic Epilepsy? , 2018, Cytogenetic and Genome Research.

[7]  H. van Praag,et al.  Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons , 2017, Scientific Reports.

[8]  W. Shen,et al.  Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction , 2016, Nucleic acids research.

[9]  M. Butler,et al.  Deletion of TOP3B Is Associated with Cognitive Impairment and Facial Dysmorphism , 2016, Cytogenetic and Genome Research.

[10]  P. Mckinnon.  Topoisomerases and the regulation of neural function , 2016, Nature Reviews Neuroscience.

[11]  M. Bear,et al.  Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex , 2015, Proceedings of the National Academy of Sciences.

[12]  R. Hen,et al.  Running rescues a fear-based contextual discrimination deficit in aged mice , 2015, Front. Syst. Neurosci..

[13]  K. Stover,et al.  Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease , 2015, Behavioural Brain Research.

[14]  K. Bath,et al.  Fragile X mental retardation protein regulates olfactory sensitivity but not odorant discrimination. , 2015, Chemical senses.

[15]  Andreas R. Pfenning,et al.  Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes , 2015, Cell.

[16]  Laura M. Tully,et al.  Social impairment in schizophrenia: new approaches for treating a persistent problem , 2015, Current opinion in psychiatry.

[17]  H. Cameron,et al.  Adult Neurogenesis and Mental Illness , 2015, Neuropsychopharmacology.

[18]  Qi Ding,et al.  Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background , 2014, Behavioural Brain Research.

[19]  J. Lucas,et al.  Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders , 2014, Front. Behav. Neurosci..

[20]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[21]  G. Ming,et al.  Functions and dysfunctions of adult hippocampal neurogenesis. , 2014, Annual review of neuroscience.

[22]  Sadegh Nabavi,et al.  Engineering a memory with LTD and LTP , 2014, Nature.

[23]  F. Chédin,et al.  Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. , 2014, Molecular cell.

[24]  S. Siris,et al.  Anxiety comorbidity in schizophrenia , 2013, Psychiatry Research.

[25]  Stormy J. Chamberlain,et al.  Topoisomerases facilitate transcription of long genes linked to autism , 2013, Nature.

[26]  Grant W. Brown,et al.  Top3β is an RNA topoisomerase that works with Fragile X syndrome protein to promote synapse formation , 2013, Nature Neuroscience.

[27]  M. Jarvelin,et al.  Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders , 2013, Nature Neuroscience.

[28]  M. Bear,et al.  Fragile X mental retardation protein and synaptic plasticity , 2013, Molecular Brain.

[29]  S. Levy,et al.  De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia , 2012, Nature Genetics.

[30]  Kenny Q. Ye,et al.  De Novo Gene Disruptions in Children on the Autistic Spectrum , 2012, Neuron.

[31]  Lukas Burger,et al.  Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state , 2012, Proceedings of the National Academy of Sciences.

[32]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[33]  Mark F Bear,et al.  Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. , 2012, Cold Spring Harbor perspectives in biology.

[34]  Alex Martin,et al.  Depression and Anxiety Symptoms in Children and Adolescents with Autism Spectrum Disorders without Intellectual Disability. , 2012, Research in autism spectrum disorders.

[35]  M. Carella,et al.  22q11.2 Distal Deletion Syndrome: Description of a New Case with Truncus Arteriosus Type 2 and Review , 2011, Molecular Syndromology.

[36]  T. Abe,et al.  Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. , 2011, Human molecular genetics.

[37]  A. Achim,et al.  How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association. , 2011, Schizophrenia bulletin.

[38]  M. Mattson,et al.  The AAA+ ATPase Thorase Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior , 2011, Cell.

[39]  Luis Alejandro Rojas,et al.  The C-Terminal Domain of RNA Polymerase II Is Modified by Site-Specific Methylation , 2011, Science.

[40]  M. Buchsbaum,et al.  Correlations between ventricular enlargement and gray and white matter volumes of cortex, thalamus, striatum, and internal capsule in schizophrenia , 2011, European Archives of Psychiatry and Clinical Neuroscience.

[41]  K. Becker,et al.  Disease and phenotype gene set analysis of disease-based gene expression in mouse and human. , 2010, Physiological genomics.

[42]  F. Gage,et al.  New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? , 2010, Nature Reviews Neuroscience.

[43]  G. Kreiman,et al.  Widespread transcription at neuronal activity-regulated enhancers , 2010, Nature.

[44]  Supriyo De,et al.  Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information , 2010, BMC Medical Genomics.

[45]  Holly Moore,et al.  A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition , 2008, Proceedings of the National Academy of Sciences.

[46]  P. Fitzgerald,et al.  Evidence for impaired long-term potentiation in schizophrenia and its relationship to motor skill learning. , 2008, Cerebral cortex.

[47]  A. Shaw,et al.  Development of autoimmunity in mice lacking DNA topoisomerase 3β , 2007, Proceedings of the National Academy of Sciences.

[48]  C. Vorhees,et al.  Morris water maze: procedures for assessing spatial and related forms of learning and memory , 2006, Nature Protocols.

[49]  M. Yaffe.  Faculty Opinions recommendation of A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. , 2006 .

[50]  C. Glass,et al.  A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription , 2006, Science.

[51]  Chunmei Zhao,et al.  Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus , 2006, The Journal of Neuroscience.

[52]  C. Vorhees,et al.  Abnormal neurodevelopment, neurosignaling and behaviour in Npas3‐deficient mice , 2005, The European journal of neuroscience.

[53]  Seon-Young Kim,et al.  PAGE: Parametric Analysis of Gene Set Enrichment , 2005, BMC Bioinform..

[54]  J. Piven,et al.  Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice , 2004, Genes, brain, and behavior.

[55]  F. Volkmar,et al.  Autism , 2003, The Lancet.

[56]  F. Gage,et al.  Functional neurogenesis in the adult hippocampus , 2002, Nature.

[57]  Kelvin Y. Kwan,et al.  Mice lacking DNA topoisomerase IIIβ develop to maturity but show a reduced mean lifespan , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Alcino J. Silva,et al.  The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. , 1998, Behavioral neuroscience.

[59]  M. Bear,et al.  A synaptic basis for memory storage in the cerebral cortex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[60]  Jane S. Paulsen,et al.  The nature of learning and memory impairments in schizophrenia , 1995, Journal of the International Neuropsychological Society.

[61]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[62]  L. Jarrard.  On the role of the hippocampus in learning and memory in the rat. , 1993, Behavioral and neural biology.

[63]  M. Fanselow,et al.  Modality-specific retrograde amnesia of fear. , 1992, Science.

[64]  R. Gur,et al.  Neuropsychological function in schizophrenia. Selective impairment in memory and learning. , 1991, Archives of general psychiatry.

[65]  J. Crawley.  Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines , 1981, Pharmacology Biochemistry and Behavior.

[66]  F. Goodwin,et al.  Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines , 1980, Pharmacology Biochemistry and Behavior.