Lead Levels in Non-Occupationally Exposed Women with Preeclampsia

There are many controversies regarding the relationship between lead exposure andcomplications in pregnancy. Preeclampsia (PE) is a maternal hypertensive disorder which is one of the main causes of maternal and foetal mortality. The aim of our study was to assess blood lead level (BLL) in Polish women with PE (PE group, n = 66) compared with healthy, non-pregnant women (CNP group, n = 40) and healthy pregnant women (CP group, n = 40). BLL was determined by inductively coupled plasma mass spectrometry (ICP-MS). The systolic blood pressure (SBP), diastolic blood pressure (DBP) and BLL in the CP group were significantly lower than in the PE group (p < 0.001). Logistic regression analyses of BLL showed a significant positive relationship with the presence of PE. Furthermore, both the SBP and DBP values were positively associated with BLL. This study indicates that preeclamptic women tend to present with significantly higher BLL compared to healthy pregnant women. There were no differences in the BLL between the CP and CNP groups.

[1]  J. Backstrand,et al.  Lead Toxicity and Pollution in Poland , 2020, International journal of environmental research and public health.

[2]  Ł. Komsta,et al.  Chemical elements and preeclampsia - An overview of current problems, challenges and significance of recent research. , 2020, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[3]  Disha,et al.  Association of raised blood lead levels in pregnant women with preeclampsia: A study at tertiary centre. , 2019, Taiwanese journal of obstetrics & gynecology.

[4]  P. Vokonas,et al.  Low‐Level Cumulative Lead and Resistant Hypertension: A Prospective Study of Men Participating in the Veterans Affairs Normative Aging Study , 2018, Journal of the American Heart Association.

[5]  W. H. Pearse,et al.  American College of Obstetricians and Gynecologists , 2018, Definitions.

[6]  R. Hornung,et al.  Low-level lead exposure and mortality in US adults: a population-based cohort study. , 2018, The Lancet. Public health.

[7]  M. Nasiri,et al.  The Relationship Between Blood Lead Level and Preeclampsia , 2016, Electronic physician.

[8]  B. Fagerberg,et al.  Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort. , 2016, Environmental research.

[9]  Alan J. Taylor,et al.  Revisiting mobilisation of skeletal lead during pregnancy based on monthly sampling and cord/maternal blood lead relationships confirm placental transfer of lead , 2016, Archives of Toxicology.

[10]  Y. Hong,et al.  Biomonitoring of Lead, Cadmium, Total Mercury, and Methylmercury Levels in Maternal Blood and in Umbilical Cord Blood at Birth in South Korea , 2015, International journal of environmental research and public health.

[11]  C. Prada,et al.  Endothelial dysfunction and preeclampsia: role of oxidative stress , 2014, Front. Physiol..

[12]  N. A. Jameil.  Maternal serum lead levels and risk of preeclampsia in pregnant women: a cohort study in a maternity hospital, Riyadh, Saudi Arabia. , 2014, International journal of clinical and experimental pathology.

[13]  J. Golding,et al.  Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: a prospective birth cohort study , 2014, BJOG : an international journal of obstetrics and gynaecology.

[14]  P. Magnus,et al.  Predictors of environmental lead exposure among pregnant women - a prospective cohort study in Poland. , 2014, Annals of agricultural and environmental medicine : AAEM.

[15]  M. Lamyian,et al.  PREDICTION OF PREECLAMPSIA BASED ON BLOOD LEAD LEVELS IN EARLY PREGNANCY , 2014 .

[16]  K. Joseph,et al.  Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. , 2013, American journal of obstetrics and gynecology.

[17]  D. Chou,et al.  Global and regional estimates of preeclampsia and eclampsia: a systematic review. , 2013, European journal of obstetrics, gynecology, and reproductive biology.

[18]  Aimls Ikaraoha Chidiebere Ikechukwu MSc,et al.  Blood Lead, Calcium, and Phosphorus in Women With Preeclampsia in Edo State, Nigeria , 2012 .

[19]  Ikaraoha Chidiebere Ikechukwu,et al.  Blood Lead, Calcium, and Phosphorus in Women With Preeclampsia in Edo State, Nigeria , 2012, Archives of environmental & occupational health.

[20]  K. Osungbade,et al.  Public Health Perspectives of Preeclampsia in Developing Countries: Implication for Health System Strengthening , 2011, Journal of pregnancy.

[21]  A. Ettinger,et al.  Guidelines for the identification and management of lead exposure in pregnant and lactating women , 2010 .

[22]  R. Slama,et al.  Maternal Blood Lead Levels and the Risk of Pregnancy-Induced Hypertension: The EDEN Cohort Study , 2009, Environmental health perspectives.

[23]  Lelia Duley,et al.  The global impact of pre-eclampsia and eclampsia. , 2009, Seminars in perinatology.

[24]  N. Vaziri,et al.  Mechanisms of lead-induced hypertension and cardiovascular disease. , 2008, American journal of physiology. Heart and circulatory physiology.

[25]  R. Pijnenborg,et al.  The uterine spiral arteries in human pregnancy: facts and controversies. , 2006, Placenta.

[26]  D. Krewski,et al.  Environmental lead level and pregnancy-induced hypertension. , 2006, Environmental research.

[27]  K. Yokoyama,et al.  Lead and other trace metals in preeclampsia: a case-control study in Tehran, Iran. , 2006, Environmental research.

[28]  I. Sargent,et al.  Latest Advances in Understanding Preeclampsia , 2005, Science.

[29]  D. Bellinger.  Teratogen update: lead and pregnancy. , 2005, Birth defects research. Part A, Clinical and molecular teratology.

[30]  S. Araki,et al.  Relationship between Increased Blood Lead and Pregnancy Hypertension in Women without Occupational Lead Exposure in Tehran, Iran , 2004, Archives of environmental health.

[31]  C. Savona-Ventura,et al.  Lead and other metals in gestational hypertension , 2003, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[32]  B. Sibai,et al.  Diagnosis and management of gestational hypertension and preeclampsia. , 2003, Obstetrics and gynecology.

[33]  R. Srivastava,et al.  Relationships of maternal blood lead and disorders of pregnancy to neonatal birthweight. , 2002, Veterinary and human toxicology.

[34]  S. Yagel,et al.  Regulation of trophoblast invasion: from normal implantation to pre-eclampsia , 2002, Molecular and Cellular Endocrinology.

[35]  E. Dawson,et al.  Blood cell lead, calcium, and magnesium levels associated with pregnancy-induced hypertension and preeclampsia , 2000, Biological Trace Element Research.

[36]  N. Chu,et al.  Reappraisal of the relation between blood lead concentration and blood pressure among the general population in Taiwan. , 1999, Occupational and environmental medicine.

[37]  C. Bulpitt,et al.  Lead Exposure and Conventional and Ambulatory Blood Pressure: A Prospective Population Study , 1996 .

[38]  D. Goffman,et al.  Maternal age and preeclampsia outcomes: 318 , 2019, American Journal of Obstetrics and Gynecology.

[39]  B. Lanphear,et al.  Blood lead and preeclampsia: A meta‐analysis and review of implications , 2018, Environmental research.

[40]  T. S. Peixe,et al.  Lead Exposure and Oxidative Stress: A Systematic Review. , 2016, Reviews of environmental contamination and toxicology.

[41]  P. Voogt.  Reviews of Environmental Contamination and Toxicology Volume 236 , 2016 .

[42]  I. Bergdahl,et al.  Chapter 43 – Lead , 2015 .

[43]  J. Sommar,et al.  Investigation of lead concentrations in whole blood, plasma and urine as biomarkers for biological monitoring of lead exposure , 2014, Journal of Exposure Science and Environmental Epidemiology.

[44]  S. Motawei,et al.  Lead level in pregnant women suffering from pre-eclampsia in Dakahlia, Egypt. , 2013, The international journal of occupational and environmental medicine.

[45]  Committee opinion No. 533: lead screening during pregnancy and lactation. , 2012, Obstetrics and gynecology.

[46]  A. Derkacz,et al.  [Relationship between chronic exposure to lead, cadmium and manganese, blood pressure values and incidence of arterial hypertension]. , 2010, Medycyna pracy.

[47]  Motao Zhu,et al.  Racial disparity in hypertensive disorders of pregnancy in New York State: a 10-year longitudinal population-based study. , 2007, American journal of public health.

[48]  D. Bellinger.  Teratogen Update Teratogen Update: Lead and Pregnancy , 2005 .