论文信息 - Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma

Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma

ABSTRACT In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation of membrane ruffles in response to growth factor receptor stimulation.

Mariana Cooke

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