The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21CIP1/Waf1

[1]  D. Latchman,et al.  Heat shock protein-56 is induced by cardiotrophin-1 and mediates its hypertrophic effect. , 2001, Journal of molecular and cellular cardiology.

[2]  D. Latchman,et al.  Brn-3a Activates the Expression of Bcl-xL and Promotes Neuronal Survival in Vivo as Well as in Vitro , 2001, Molecular and Cellular Neuroscience.

[3]  D. Latchman,et al.  The BRN-3A Transcription Factor Protects Sensory but Not Sympathetic Neurons from Programmed Cell Death/Apoptosis* , 2001, The Journal of Biological Chemistry.

[4]  E. Turner,et al.  Defects in Sensory Axon Growth Precede Neuronal Death in Brn3a-Deficient Mice , 2001, The Journal of Neuroscience.

[5]  D. Latchman,et al.  p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor* , 1999, The Journal of Biological Chemistry.

[6]  Mark D. Johnson,et al.  Contribution of p53-Dependent Caspase Activation to Neuronal Cell Death Declines with Neuronal Maturation , 1999, The Journal of Neuroscience.

[7]  D. Latchman,et al.  Bcl-2 Transcription from the Proximal P2 Promoter Is Activated in Neuronal Cells by the Brn-3a POU Family Transcription Factor* , 1998, The Journal of Biological Chemistry.

[8]  D. Rosenbaum,et al.  Apoptosis in neurological disease. , 1998, Neurosurgery.

[9]  M. Dragunow,et al.  Cycloheximide phase‐shifts, but does not prevent, de novo Krox‐24 protein expression , 1997, Neuroreport.

[10]  M. Schwartz,et al.  Coordinate Induction of the Three Neurofilament Genes by the Brn-3a Transcription Factor* , 1997, The Journal of Biological Chemistry.

[11]  M. Rosenfeld,et al.  POU domain family values: flexibility, partnerships, and developmental codes. , 1997, Genes & development.

[12]  D. Latchman,et al.  The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins , 1997, Molecular and cellular biology.

[13]  P. Sawchenko,et al.  Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons , 1996, Nature.

[14]  J. Nathans,et al.  Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[15]  V. Rotter,et al.  p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells , 1996, Molecular and cellular biology.

[16]  S. Korsmeyer,et al.  BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development , 1996, Neuron.

[17]  C. Prives,et al.  p53: puzzle and paradigm. , 1996, Genes & development.

[18]  E. Turner,et al.  Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors , 1995, Mechanisms of Development.

[19]  S. Korsmeyer,et al.  Role of BCL-2 in the survival and function of developing and mature sympathetic neurons , 1995, Neuron.

[20]  T. Möröy,et al.  Regulation of Neurite Outgrowth and SNAP-25 Gene Expression by the Brn-3a Transcription Factor (*) , 1995, The Journal of Biological Chemistry.

[21]  T. Möröy,et al.  Activation of the α-Internexin Promoter by the Brn-3a Transcription Factor Is Dependent on the N-terminal Region of the Protein (*) , 1995, The Journal of Biological Chemistry.

[22]  John Calvin Reed,et al.  Tumor suppressor p53 is a direct transcriptional activator of the human bax gene , 1995, Cell.

[23]  D. Latchman,et al.  The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells. , 1994, Nucleic acids research.

[24]  John Calvin Reed,et al.  Identification of a p53-dependent negative response element in the bcl-2 gene. , 1994, Cancer research.

[25]  J. Trent,et al.  WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.

[26]  E. Turner,et al.  Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[27]  S. Korsmeyer,et al.  Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair , 1993, Cell.

[28]  C. Verrijzer,et al.  POU domain transcription factors. , 1993, Biochimica et biophysica acta.

[29]  D. Latchman,et al.  A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells. , 1992, Nucleic acids research.

[30]  S. Bevan,et al.  Novel cell lines display properties of nociceptive sensory neurons , 1990, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[31]  L. Swanson,et al.  Expression of a large family of POU-domain regulatory genes in mammalian brain development , 1989, Nature.

[32]  V. Hamburger,et al.  Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor , 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[33]  M. Sieber-Blum,et al.  Growth factor synergism and antagonism in early neural crest development. , 1998, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[34]  S. D’Mello Molecular regulation of neuronal apoptosis. , 1998, Current topics in developmental biology.