Abnormal eye movements in parkinsonism: a historical view

ABSTRACT Parkinson's disease (PD), known since ancient times as paralysis agitans, was studied and described by James Parkinson in 1817 in his work “An Essay on the Shaking Palsy”. Fifty years later, Charcot and his students delved into the disease, naming it as we know it today, as well as defining the classic disease and its variants. One of these students, Arthur Dutil, addressed patients’ abnormal eye movements. Nowadays, it is known that the differential diagnosis of PD is relevant for prognosis, treatment and research, and, despite the advances in the area, it remains largely clinical. The relevance of the eye movement exam has grown along with the history of PD and it has proved to be an excellent tool for the differential diagnosis of parkinsonism. Additionally, it can become a support to identify different types of genetic PD and be useful for improving early recognition of cognitive decline in patients with PD.

[1]  B. Chwalisz,et al.  Ocular motor manifestations of movement disorders. , 2019, Current opinion in ophthalmology.

[2]  O. W. Wong,et al.  Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking. , 2019, Journal of visualized experiments : JoVE.

[3]  Y. Terao,et al.  Differentiating early Parkinson's disease and multiple system atrophy with parkinsonism by saccade velocity profiles , 2019, Clinical Neurophysiology.

[4]  Ji-Soo Kim,et al.  Abnormal Eye Movements in Parkinsonism and Movement Disorders , 2019, Journal of movement disorders.

[5]  A. Lees,et al.  Saccadic Direction Errors are Associated with Impulsive Compulsive Behaviours in Parkinson's Disease Patients. , 2019, Journal of Parkinson's disease.

[6]  P. Svenningsson,et al.  Eye movements during reading in Parkinson's disease: A pilot study , 2018, Movement disorders : official journal of the Movement Disorder Society.

[7]  J. Kassubek,et al.  Structural and Functional Brain Mapping Correlates of Impaired Eye Movement Control in Parkinsonian Syndromes: A Systems-Based Concept , 2018, Front. Neurol..

[8]  Lance M. Optican,et al.  Eye Movements in Parkinson’s Disease and Inherited Parkinsonian Syndromes , 2017, Front. Neurol..

[9]  M. Hallett,et al.  Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy , 2017, Movement disorders : official journal of the Movement Disorder Society.

[10]  Y. J. Liao,et al.  Abnormal eye movement behavior during reading in Parkinson's disease. , 2016, Parkinsonism & related disorders.

[11]  L S Illis,et al.  Handbook of clinical neurology , 2013, Spinal Cord.

[12]  C. Goetz.  The history of Parkinson's disease: early clinical descriptions and neurological therapies. , 2011, Cold Spring Harbor perspectives in medicine.

[13]  James Parkinson,et al.  An essay on the shaking palsy. 1817. , 2002, The Journal of neuropsychiatry and clinical neurosciences.

[14]  C. Goetz.  An early photographic case of probable progressive supranuclear palsy , 1996 .

[15]  R. Duvoisin.  A brief history of parkinsonism. , 1992, Neurologic clinics.

[16]  C. Goetz,et al.  Charcot on Parkinson's disease , 1986, Movement disorders : official journal of the Movement Disorder Society.

[17]  M. Swash,et al.  Post-encephalitic Parkinsonism: current experience , 1981, Journal of neurology, neurosurgery, and psychiatry.

[18]  H. Shibasaki,et al.  Oculomotor abnormalities in Parkinson's disease. , 1979, Archives of neurology.

[19]  M. B. Bender,et al.  Oculomotor function in patients with Parkinson's disease. , 1972, Journal of the neurological sciences.

[20]  A. Veronese,et al.  Modifications of the vestibulo-ocular responses in parkinsonian patients after thalamolysis. An electronystagmographic study. , 1965, Confinia neurologica.