Electroforming of Implantable Tubular Magnetic Microrobots for Wireless Ophthalmologic Applications

Magnetic tubular implantable micro-robots are batch fabricated by electroforming. These microdevices can be used in targeted drug delivery and minimally invasive surgery for ophthalmologic applications. These tubular shapes are fitted into a 23-gauge needle enabling sutureless injections. Using a 5-degree-of-freedom magnetic manipulation system, the microimplants are conveniently maneuvered in biological environments. To increase their functionality, the tubes are coated with biocompatible films and can be successfully filled with drugs.

[1]  D. Morck,et al.  Drug delivery to the posterior segment of the eye through hydrogel contact lenses , 2011, Clinical & experimental optometry.

[2]  S. Whitcup,et al.  New developments in sustained release drug delivery for the treatment of intraocular disease , 1999, The British journal of ophthalmology.

[3]  Robert Langer,et al.  Reservoir-based drug delivery systems utilizing microtechnology. , 2012, Advanced drug delivery reviews.

[4]  Antonios G Mikos,et al.  Gelatin as a delivery vehicle for the controlled release of bioactive molecules. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[5]  T. Groth,et al.  Testing the cytotoxicity of metal alloys used as magnetic prosthetic devices , 2003, Journal of materials science. Materials in medicine.

[6]  O. Schmidt,et al.  Nanotechnology: Thin solid films roll up into nanotubes , 2001, Nature.

[7]  B. Gilger,et al.  Advancements in ocular drug delivery. , 2010, Veterinary ophthalmology.

[8]  Robert J Greenberg,et al.  Microsensors and microbiosensors for retinal implants. , 2005, Frontiers in bioscience : a journal and virtual library.

[9]  J. Escrig,et al.  Reversal modes and magnetostatic interactions in Fe3O4/ZrO2/Fe3O4 multilayer nanotubes , 2012, Nanotechnology.

[10]  M. Junkar,et al.  Miniaturization of injection abrasive water jet machining process , 2006 .

[11]  P. A. Pearson,et al.  Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study. , 2006, Ophthalmology.

[12]  R. Guss,et al.  Rhodamine B as a test molecule in intraocular dynamics. , 1984, Investigative ophthalmology & visual science.

[13]  S. Pané,et al.  Redox Cycling for Passive Modification of Polypyrrole Surface Properties: Effects on Cell Adhesion and Proliferation , 2013, Advanced healthcare materials.

[14]  Ioannis K. Kaliakatsos,et al.  Microrobots for minimally invasive medicine. , 2010, Annual review of biomedical engineering.

[15]  Jake J. Abbott,et al.  Robotics in the Small, Part I: Microbotics , 2007, IEEE Robotics & Automation Magazine.

[16]  W. Kao,et al.  Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems , 2010, Expert opinion on drug delivery.

[17]  A. Sher,et al.  Photovoltaic Retinal Prosthesis with High Pixel Density , 2012, Nature Photonics.

[18]  Kalayaan V. Bilbao,et al.  THE CHICK CHORIOALLANTOIC MEMBRANE AS A MODEL TISSUE FOR SURGICAL RETINAL RESEARCH AND SIMULATION , 2004, Retina.

[19]  S. Young,et al.  Drug delivery to the posterior segment of the eye. , 2011, Drug discovery today.

[20]  Li Zhang,et al.  Artificial bacterial flagella for micromanipulation. , 2010, Lab on a chip.

[21]  Chi-Hwa Wang,et al.  Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems. , 2006, Advanced drug delivery reviews.

[22]  N Rajgor,et al.  Implantable drug delivery systems: An overview , 2011 .

[23]  Franziska Ullrich,et al.  Mobility experiments with microrobots for minimally invasive intraocular surgery. , 2013, Investigative ophthalmology & visual science.

[24]  W. Xi,et al.  Rolled-up magnetic microdrillers: towards remotely controlled minimally invasive surgery. , 2013, Nanoscale.

[25]  A. Scherz,et al.  Evaluation of the new photosensitizer Stakel (WST-11) for photodynamic choroidal vessel occlusion in rabbit and rat eyes. , 2008, Investigative ophthalmology & visual science.

[26]  S. Downes,et al.  The use of gelatin as a vehicle for drug and peptide delivery , 1994 .

[27]  Samuel Sanchez,et al.  Fabrication and applications of large arrays of multifunctional rolled-up SiO/SiO2 microtubes , 2012 .

[28]  Yong Tang,et al.  Experimental study of oil-filled high-speed spin forming micro-groove fin-inside tubes , 2007 .

[29]  Warren Apel,et al.  Cobalt–chromium toxic retinopathy case study , 2013, Documenta Ophthalmologica.

[30]  E. Beyne,et al.  Electrodeposition for the synthesis of microsystems , 2000 .

[31]  Young H. Kwon,et al.  Novel drug delivery systems for glaucoma , 2011, Eye.

[32]  U. Schmidt-Erfurth,et al.  Guidance for the treatment of neovascular age-related macular degeneration. , 2007, Acta ophthalmologica Scandinavica.

[33]  Juho Pokki,et al.  In Vitro Oxygen Sensing Using Intraocular Microrobots , 2012, IEEE Transactions on Biomedical Engineering.

[34]  M. Sanford.  Fluocinolone Acetonide Intravitreal Implant (Iluvien®) , 2013, Drugs.

[35]  Y. Tai,et al.  Wireless Intraocular Pressure Sensing Using Microfabricated Minimally Invasive Flexible-Coiled LC Sensor Implant , 2010, Journal of Microelectromechanical Systems.

[36]  W. Xi,et al.  Self-propelled nanotools. , 2012, ACS nano.