A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

[1]  M. Tencerova,et al.  Obesity-Induced Changes in Bone Marrow Homeostasis , 2020, Frontiers in Endocrinology.

[2]  Julian M. W. Quinn,et al.  An atlas of genetic influences on osteoporosis in humans and mice , 2018, Nature Genetics.

[3]  O. Andreassen,et al.  A global overview of pleiotropy and genetic architecture in complex traits , 2019, Nature Genetics.

[4]  Anthony J. Payne,et al.  Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps , 2018, Nature Genetics.

[5]  D. Kiel,et al.  Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study , 2018, British Medical Journal.

[6]  M. Brand,et al.  Osteoblast‐like MC3T3‐E1 Cells Prefer Glycolysis for ATP Production but Adipocyte‐like 3T3‐L1 Cells Prefer Oxidative Phosphorylation , 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  Christopher D. Scharer,et al.  Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs , 2018, Nature Communications.

[8]  N. Risch,et al.  A large electronic health record-based genome-wide study of serum lipids , 2018, Nature Genetics.

[9]  Łukasz M. Boryń,et al.  Resolving systematic errors in widely-used enhancer activity assays in human cells , 2017, Nature Methods.

[10]  G. Gilfillan,et al.  Native Chromatin Immunoprecipitation-Sequencing (ChIP-Seq) from Low Cell Numbers. , 2018, Methods in molecular biology.

[11]  P. Visscher,et al.  Multi-trait analysis of genome-wide association summary statistics using MTAG , 2017, Nature Genetics.

[12]  Kyle J. Gaulton,et al.  Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci , 2017, bioRxiv.

[13]  Y. Hsu,et al.  Identifying Pleiotropic Effects: A Two-Stage Approach Using Genome-Wide Association Meta-Analysis Data , 2017, bioRxiv.

[14]  Stephen C. J. Parker,et al.  A Type 2 Diabetes–Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus , 2017, Diabetes.

[15]  P. Visscher,et al.  MTAG: Multi-Trait Analysis of GWAS , 2017, bioRxiv.

[16]  Evan Z. Macosko,et al.  Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types , 2017, Nature Genetics.

[17]  Helen E. Parkinson,et al.  The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog) , 2016, Nucleic Acids Res..

[18]  Xiaofeng Zhu,et al.  Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium , 2016, PloS one.

[19]  Stephen C. J. Parker,et al.  The genetic architecture of type 2 diabetes , 2016, Nature.

[20]  David R. Kelley,et al.  Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks , 2015, bioRxiv.

[21]  Joseph K. Pickrell,et al.  Detection and interpretation of shared genetic influences on 42 human traits , 2015, Nature Genetics.

[22]  Mark I. McCarthy,et al.  Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors , 2015, PLoS genetics.

[23]  Eric Haugen,et al.  Large-scale identification of sequence variants impacting human transcription factor occupancy in vivo , 2015, Nature Genetics.

[24]  Yakir A Reshef,et al.  Partitioning heritability by functional annotation using genome-wide association summary statistics , 2015, Nature Genetics.

[25]  Manolis Kellis,et al.  FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. , 2015, The New England journal of medicine.

[26]  Jonathan K. Pritchard,et al.  WASP: allele-specific software for robust molecular quantitative trait locus discovery , 2015, Nature Methods.

[27]  L. Rubin,et al.  Clonal analyses and gene profiling identify genetic biomarkers of human brown and white preadipocyte thermogenic potential , 2015, Nature medicine.

[28]  Benjamin J. Strober,et al.  A method to predict the impact of regulatory variants from DNA sequence , 2015, Nature Genetics.

[29]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[30]  C. Farber,et al.  Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast , 2015, Molecular and Cellular Biology.

[31]  M. Parker,et al.  A novel de novo 20q13.32–q13.33 deletion in a 2-year-old child with poor growth, feeding difficulties and low bone mass , 2015, Journal of Human Genetics.

[32]  Jing Liang,et al.  Chromatin architecture reorganization during stem cell differentiation , 2015, Nature.

[33]  M. Brand,et al.  The contributions of respiration and glycolysis to extracellular acid production. , 2015, Biochimica et biophysica acta.

[34]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[35]  Xiaofeng Zhu,et al.  Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension. , 2015, American journal of human genetics.

[36]  Howard Y. Chang,et al.  ATAC‐seq: A Method for Assaying Chromatin Accessibility Genome‐Wide , 2015, Current protocols in molecular biology.

[37]  C. Ling,et al.  Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets , 2014, PLoS genetics.

[38]  G. Shulman Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. , 2014, The New England journal of medicine.

[39]  Kate B. Cook,et al.  Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity , 2014, Cell.

[40]  G. Rutter,et al.  ADCY5 Couples Glucose to Insulin Secretion in Human Islets , 2014, Diabetes.

[41]  Bernhard Horsthemke,et al.  Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms , 2014, Cell.

[42]  Tom C Freeman,et al.  An expression atlas of human primary cells: inference of gene function from coexpression networks , 2013, BMC Genomics.

[43]  P. Arner,et al.  Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass , 2013, PLoS biology.

[44]  C. Ling,et al.  Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets , 2013, Diabetologia.

[45]  J. Kanis,et al.  Type 2 diabetes and bone , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[46]  S. Dankel,et al.  The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss , 2012, International Journal of Obesity.

[47]  L. Mirny,et al.  Iterative Correction of Hi-C Data Reveals Hallmarks of Chromosome Organization , 2012, Nature Methods.

[48]  Swneke D. Bailey,et al.  Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression , 2012, Nature Genetics.

[49]  D. Kiel,et al.  Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits , 2012, Diabetes.

[50]  Claude Bouchard,et al.  A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance , 2012, Nature Genetics.

[51]  Daniel L. Koller,et al.  Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture , 2012, Nature Genetics.

[52]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[53]  Manolis Kellis,et al.  ChromHMM: automating chromatin-state discovery and characterization , 2012, Nature Methods.

[54]  David Haussler,et al.  The Human Epigenome Browser at Washington University , 2011, Nature Methods.

[55]  F. Agakov,et al.  Abundant pleiotropy in human complex diseases and traits. , 2011, American journal of human genetics.

[56]  V. Steen,et al.  Switch from Stress Response to Homeobox Transcription Factors in Adipose Tissue After Profound Fat Loss , 2010, PloS one.

[57]  Jason H. Moore,et al.  Missing heritability and strategies for finding the underlying causes of complex disease , 2010, Nature Reviews Genetics.

[58]  Alex Doney,et al.  Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge , 2010, Nature Genetics.

[59]  Christian Gieger,et al.  New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , 2010, Nature Genetics.

[60]  Esko Ukkonen,et al.  MOODS: fast search for position weight matrix matches in DNA sequences , 2009, Bioinform..

[61]  F. Collins,et al.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.

[62]  M. Czech,et al.  Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes , 2008, Nature Reviews Molecular Cell Biology.

[63]  R. Verhaak,et al.  A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. , 2007, The Journal of clinical investigation.

[64]  J. Aubin,et al.  LIF Inhibits Osteoblast Differentiation at Least in Part by Regulation of HAS2 and Its Product Hyaluronan , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[65]  P. Fischer-Posovszky,et al.  Human SGBS preadipocytes – an unique tool for studies of human adipocyte biology , 2007 .

[66]  P. Vestergaard,et al.  Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis , 2007, Osteoporosis International.

[67]  H. Hauner,et al.  Primary culture and differentiation of human adipocyte precursor cells. , 2005, Methods in molecular medicine.

[68]  Ton Feuth,et al.  Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes , 2005, Laboratory Investigation.

[69]  D. Haussler,et al.  Aligning multiple genomic sequences with the threaded blockset aligner. , 2004, Genome research.

[70]  T. Kohwi-Shigematsu,et al.  Tissue-specific nuclear architecture and gene expession regulated by SATB1 , 2003, Nature Genetics.

[71]  D Tabor,et al.  Regulation of gene expression by SREBP and SCAP. , 2000, Biochimica et biophysica acta.

[72]  J. Hanoune,et al.  Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. , 2000, American journal of physiology. Renal physiology.

[73]  D. Baylink,et al.  Skeletal alkaline phosphatase activity as a bone formation index in vitro. , 1986, Metabolism: clinical and experimental.