Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.

[1]  Edwin K Silverman,et al.  Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. , 2012, Human molecular genetics.

[2]  L. Edwards,et al.  A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. , 2012, Human molecular genetics.

[3]  D. Grossman,et al.  Role of the apoptotic and mitotic regulator survivin in melanoma. , 2012, Anticancer research.

[4]  Benjamin Haibe-Kains,et al.  Predictive networks: a flexible, open source, web application for integration and analysis of human gene networks , 2011, Nucleic Acids Res..

[5]  C. Sato,et al.  Novel Regulation of Fibroblast Growth Factor 2 (FGF2)-mediated Cell Growth by Polysialic Acid* , 2011, The Journal of Biological Chemistry.

[6]  A. Polizio,et al.  Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins , 2011, Science Signaling.

[7]  S. Bellino,et al.  Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma , 2011, International journal of vascular medicine.

[8]  Robert L. Sutherland,et al.  Cyclin D as a therapeutic target in cancer , 2011, Nature Reviews Cancer.

[9]  E. Silverman,et al.  On the follow‐up of genome‐wide association studies: an overall test for the most promising SNPs , 2011, Genetic epidemiology.

[10]  P. Ingham,et al.  Mechanisms and functions of Hedgehog signalling across the metazoa , 2011, Nature Reviews Genetics.

[11]  M. Kai,et al.  Hypoxia activates the hedgehog signaling pathway in a ligand‐independent manner by upregulation of Smo transcription in pancreatic cancer , 2011, Cancer science.

[12]  Andrew E. Teschendorff,et al.  Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies , 2011, Bioinform..

[13]  J. Couchman,et al.  Syndecans as cell surface receptors: Unique structure equates with functional diversity. , 2011, Matrix biology : journal of the International Society for Matrix Biology.

[14]  A. M. Herrera,et al.  Fibrotic Response of Tissue Remodeling in COPD , 2011, Lung.

[15]  David X. Liu,et al.  BCL-2 Is a Downstream Target of ATF5 That Mediates the Prosurvival Function of ATF5 in a Cell Type-dependent Manner* , 2011, The Journal of Biological Chemistry.

[16]  Huang-Hui Chen,et al.  Investigations of survivin: the past, present and future. , 2011, Frontiers in bioscience.

[17]  Inês Barroso,et al.  Genome-wide association study identifies five loci associated with lung function , 2010, Nature Genetics.

[18]  G. Gamble,et al.  Chromosome 4q31 locus in COPD is also associated with lung cancer , 2010, European Respiratory Journal.

[19]  P. Beachy,et al.  Interactions between Hedgehog proteins and their binding partners come into view. , 2010, Genes & development.

[20]  M. Post,et al.  Gli2 influences proliferation in the developing lung through regulation of cyclin expression. , 2010, American journal of respiratory cell and molecular biology.

[21]  Michael R. Green,et al.  A genome-wide RNA interference screen reveals an essential CREB3L2/ATF5/MCL1 survival pathway in malignant glioma with therapeutic implications , 2010, Nature Medicine.

[22]  A. Hofman,et al.  Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function , 2010, Nature Genetics.

[23]  A. Hofman,et al.  Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study , 2009, European Respiratory Journal.

[24]  W. Parks,et al.  Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines. , 2009, Blood.

[25]  S. Hymowitz,et al.  The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling , 2009, Nature Structural &Molecular Biology.

[26]  K. Shianna,et al.  A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci , 2009, PLoS genetics.

[27]  Mark I. McCarthy,et al.  Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966 , 2009, PLoS genetics.

[28]  M. Stewart,et al.  Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway , 2009, Human molecular genetics.

[29]  H. Osada,et al.  RECK negatively regulates matrix metalloproteinase-9 transcription. , 2009, Cancer research.

[30]  Antoine M. van Oijen,et al.  Real-time single-molecule observation of rolling-circle DNA replication , 2009, Nucleic acids research.

[31]  Wei Hu,et al.  Involvement of Bcl-2 family in apoptosis and signal pathways induced by cigarette smoke extract in the human airway smooth muscle cells. , 2009, DNA and cell biology.

[32]  Brad T. Sherman,et al.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.

[33]  M. Grace,et al.  Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells , 2008, Proceedings of the National Academy of Sciences.

[34]  David Warde-Farley,et al.  GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function , 2008, Genome Biology.

[35]  W. Parks,et al.  Metalloproteinases and their inhibitors: regulators of wound healing. , 2008, The international journal of biochemistry & cell biology.

[36]  David M. Evans,et al.  Genome-wide association analysis identifies 20 loci that influence adult height , 2008, Nature Genetics.

[37]  John D. Storey,et al.  Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis , 2007, PLoS genetics.

[38]  Hui-Hsuan Lin,et al.  Immunohistochemical Detection of Apoptotic Proteins, p53/Bax and JNK/FasL Cascade, in the Lung of Rats Exposed to Cigarette Smoke , 2006, Archives of Toxicology.

[39]  D. Gumucio,et al.  Epithelial hedgehog signals pattern the intestinal crypt-villus axis , 2005, Development.

[40]  A. McMahon,et al.  Combined activities of hedgehog signaling inhibitors regulate pancreas development , 2003, Development.

[41]  W. Hung,et al.  Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. , 2003, Cancer research.

[42]  K. Aoshiba,et al.  Alveolar wall apoptosis causes lung destruction and emphysematous changes. , 2003, American journal of respiratory cell and molecular biology.

[43]  Stephen B. Baylin,et al.  Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer , 2003, Nature.

[44]  N. Kaminski,et al.  Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema , 2003, Nature.

[45]  A. McMahon,et al.  Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. , 2003, Genes & development.

[46]  M. Sogayar,et al.  Transcriptional control of the RECK metastasis/angiogenesis suppressor gene. , 2002, Cancer detection and prevention.

[47]  David B. Alexander,et al.  The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis , 2001, Cell.

[48]  N J Wareham,et al.  Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction. , 2001, American journal of respiratory and critical care medicine.

[49]  Pao-Tien Chuang,et al.  Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein , 1999, Nature.

[50]  B Rosner,et al.  Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. , 1998, American journal of respiratory and critical care medicine.