A Novel Self Accommodate Control Network

A 7-(5-amino-5-carboxyvaleramido)-7-methoxycephalosporin with amino and acid groups protected is reacted with PCl5 or other agent capable of forming an imino halide; the resulting imino halide is thereafter reacted under essentially non-aqueous conditions with a primary loweralkanol of C1-C4 or with methan-d3-ol, yielding nucleus bearing a 7-alkoxy group derived from the primary loweralkanol or methan-d3-ol. In situ acylation of the nucleus affords 7-acylamido-7-alkoxycephalosporins in good yield; these products can be deesterified to yield the corresponding acids, which exhibit antibacterial activity.