Overview: Virtual Reality in Medicine

96 800x600 Normal 0 14 false false false IT JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabella normale"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Cambria;} Background: Virtual Reality (VR) was defined as a collection of technological devices: “a computer capable of interactive 3D visualization, a head-mounted display and data gloves equipped with one or more position trackers”. Today, lots of scientists define VR as a simulation of the real world based on computer graphics, a three dimensional world in which communities of real people interact, create content, items and services, producing real economic value through e-Commerce. Objective: To report the results of a systematic review of articles and reviews published about the theme: “Virtual Reality in Medicine”. Methods: We used the search query string: “Virtual Reality”, “Metaverse”, “Second Life”, “Virtual World”, “Virtual Life” in order to find out how many articles were written about these themes. For the “Meta-review” we used only “Virtual Reality” AND “Review”. We searched the following databases: Psycinfo, Journal of Medical Internet Research, Isiknowledge till September 2011 and Pubmed till February 2012. We included any source published in either print format or on the Internet, available in all languages, and containing texts that define or attempt to define VR in explicit terms. Results: We retrieved 3,443 articles on Pubmed in 2012 and 8,237 on Isiknowledge in 2011. This large number of articles covered a wide range of themes, but showed no clear consensus about VR. We identified 4 general uses of VR in Medicine, and searched for the existing reviews about them. We found 364 reviews in 2011, although only 197 were pertinent to our aims: 1. Communication Interface (11 Reviews); 2. Medical Education (49 reviews); 3. Surgical Simulation (49 Reviews) and 4. Psychotherapy (88 Reviews). Conclusion: We found a large number of articles, but no clear consensus about the meaning of the term VR in Medicine. We found numerous articles published on these topics and many of them have been reviewed. We decided to group these reviews in 4 areas in order to provide a systematic overview of the subject matter, and to enable those interested to learn more about these particular topics.

[1]  D. Moore,et al.  Collaborative Virtual Environment Technology for People With Autism , 2005 .

[2]  Mary T. Johnson,et al.  Development of Virtual Patient Simulations for Medical Education , 2009 .

[3]  B. Wolfe.  The role of lived experience in self- and relational observation: A commentary on Horowitz (2002). , 2002 .

[4]  P. Mitchell,et al.  Using Virtual Environments for Teaching Social Understanding to 6 Adolescents with Autistic Spectrum Disorders , 2007, Journal of autism and developmental disorders.

[5]  P. Tonin,et al.  Virtual Reality as an assessment tool for arm motor deficits after brain lesions. , 2001, Studies in health technology and informatics.

[6]  R. Baños,et al.  Virtual reality: a new clinical setting lab. , 1998, Studies in health technology and informatics.

[7]  Hunter G. Hoffman,et al.  Modulation of thermal pain-related brain activity with virtual reality: evidence from fMRI , 2004, Neuroreport.

[8]  G. Riva,et al.  15 Virtual Reality and Telemedicine Based Experiential Cognitive Therapy: Rationale and Clinical Protocol , 2001 .

[9]  Luc Soler,et al.  Advances in virtual reality are wide ranging , 2002, BMJ : British Medical Journal.

[10]  C Chinnock,et al.  Virtual reality in surgery and medicine. , 1994, Hospital technology series.

[11]  G Riva,et al.  Virtual reality in telemedicine. , 2000, Telemedicine journal and e-health : the official journal of the American Telemedicine Association.

[12]  Kenneth J. Ottenbacher,et al.  Virtual Reality in the Assessment of Selected Cognitive Function After Brain Injury , 2001, American journal of physical medicine & rehabilitation.

[13]  J. Dale,et al.  Effects of Distraction on Pain, Fear, and Distress During Venous Port Access and Venipuncture in Children and Adolescents With Cancer , 2007, Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses.

[14]  Brenda K. Wiederhold,et al.  A Review of Virtual Reality as a Psychotherapeutic Tool , 1998, Cyberpsychology Behav. Soc. Netw..

[15]  Todd Bowerly,et al.  A Virtual Reality Scenario for All Seasons: The Virtual Classroom , 2009, CNS Spectrums.

[16]  A. Rizzo,et al.  The application of virtual reality technology in rehabilitation. , 2001 .

[17]  Margaret M Hansen,et al.  Versatile, Immersive, Creative and Dynamic Virtual 3-D Healthcare Learning Environments: A Review of the Literature , 2008, Journal of medical Internet research.

[18]  H. Hoffman,et al.  Virtual reality exposure therapy for the treatment of posttraumatic stress disorder following September 11, 2001. , 2007, The Journal of clinical psychiatry.

[19]  David Burden,et al.  Web GIS in practice V: 3-D interactive and real-time mapping in Second Life , 2007, International journal of health geographics.

[20]  Albert A. Rizzo,et al.  A Bibliography of Articles Relevant to the Application of Virtual Reality in the Mental Health Field , 1998, Cyberpsychology Behav. Soc. Netw..

[21]  Giuseppe Riva,et al.  Guest editorial: introduction to the special issue on virtual reality environments in behavioral sciences , 2002, IEEE Trans. Inf. Technol. Biomed..

[22]  Maureen K. Holden,et al.  Virtual Environments for Motor Rehabilitation: Review , 2005, Cyberpsychology Behav. Soc. Netw..

[23]  Jaron Lanier,et al.  A hand gesture interface device , 1987, CHI 1987.

[24]  Sam Bucolo,et al.  The efficacy of an augmented virtual reality system to alleviate pain in children undergoing burns dressing changes: a randomised controlled trial. , 2008, Burns : journal of the International Society for Burn Injuries.

[25]  Joseph Murphy,et al.  Does this Avatar Make Me Look Fat? Obesity and Interviewing in Second Life , 2009 .

[26]  Concepción Perpiñá,et al.  Virtual Reality and Psychopathology , 1999, Cyberpsychology Behav. Soc. Netw..

[27]  G Riva,et al.  Virtual reality as clinical tool: immersion and three-dimensionality in the relationship between patient and therapist. , 2001, Studies in health technology and informatics.

[28]  G Riva,et al.  Applications of Virtual Environments in Medicine , 2003, Methods of Information in Medicine.

[29]  Maged N Kamel Boulos,et al.  Scientific discourse 2.0 , 2008, EMBO reports.

[30]  James R Korndorffer,et al.  Skill retention following proficiency-based laparoscopic simulator training. , 2005, Surgery.

[31]  Hunter G. Hoffman,et al.  Virtual Reality Exposure Therapy for World Trade Center Post-traumatic Stress Disorder: A Case Report , 2002, Cyberpsychology Behav. Soc. Netw..

[32]  C. Botella,et al.  Virtual reality in the treatment of spider phobia: a controlled study. , 2002, Behaviour research and therapy.

[33]  Mark B. Powers,et al.  Virtual reality exposure therapy for anxiety disorders: A meta-analysis. , 2008, Journal of anxiety disorders.

[34]  Teodor P Grantcharov,et al.  Effect of virtual reality training on laparoscopic surgery: randomised controlled trial , 2009, BMJ : British Medical Journal.

[35]  Eduardo Salas,et al.  Requirements for Future Research in Flight Simulation Training: Guidance Based on a Meta-Analytic Review , 1992 .

[36]  R. Baños,et al.  Virtual reality in eating disorders , 2003 .

[37]  J. Abramowitz,et al.  Cognitive and behavioral treatments for anxiety disorders: a review of meta-analytic findings. , 2004, Journal of clinical psychology.

[38]  Albert Rizzo,et al.  Virtual Iraq/Afghanistan: Development and Early Evaluation of a Virtual Reality Exposure Therapy System for Combat-Related PTSD , 2010 .

[39]  Albert A. Rizzo,et al.  Virtual reality and cognitive assessment and rehabilitation: the state of the art. , 1997, Studies in health technology and informatics.

[40]  S. Adamovich,et al.  Integrated arm and hand training using adaptive robotics and virtual reality simulations , 2010 .

[41]  Giuseppe Riva,et al.  The Layers of Presence: A Bio-cultural Approach to Understanding Presence in Natural and Mediated Environments , 2004, Cyberpsychology Behav. Soc. Netw..

[42]  F Vincelli,et al.  Virtual reality and imaginative techniques in clinical psychology. , 1998, Studies in health technology and informatics.

[43]  Stéphane Bouchard,et al.  Experiential Cognitive Therapy in the Treatment of Panic Disorders with Agoraphobia: A Controlled Study , 2003, Cyberpsychology Behav. Soc. Netw..

[44]  Hunter G Hoffman,et al.  Factors influencing the efficacy of virtual reality distraction analgesia during postburn physical therapy: preliminary results from 3 ongoing studies. , 2007, Archives of physical medicine and rehabilitation.

[45]  Thomas C. Meyer,et al.  Presence as the Defining Factor in a VR Application , 1994 .

[46]  P. Jeffries,et al.  TECHNOLOGY ‐ BASED vs. Traditional Instruction: A Comparison of Two Methods for TEACHING the Skill of Performing a 12‐Lead ECG , 2003, Nursing education perspectives.

[47]  Gregory B. Newby,et al.  Virtual reality: Scientific and technological challenges , 1996 .

[48]  Diane J Skiba.  Nursing education 2.0: a second look at Second Life. , 2009, Nursing education perspectives.

[49]  Concepción Perpiñá,et al.  Telepsychology: Public Speaking Fear Treatment on the Internet , 2000, Cyberpsychology Behav. Soc. Netw..

[50]  P. Mitchell,et al.  Do adolescents with autistic spectrum disorders adhere to social conventions in virtual environments? , 2005, Autism : the international journal of research and practice.

[51]  M. Bellani,et al.  Virtual reality in autism: state of the art , 2011, Epidemiology and Psychiatric Sciences.

[52]  Joanne W. Y. Chung,et al.  Application of a virtual reality prototype for pain relief of pediatric burn in Taiwan. , 2007, Journal of clinical nursing.

[53]  Rameshsharma Ramloll,et al.  Web 3D for Public, Environmental and Occupational Health: Early Examples from Second Life® , 2008, International journal of environmental research and public health.

[54]  Albert A. Rizzo,et al.  Performance-Driven Facial Animation: Basic Research on Human Judgments of Emotional State in Facial Avatars , 2001, Cyberpsychology Behav. Soc. Netw..

[55]  Gerardo Herrera,et al.  Development of symbolic play through the use of virtual reality tools in children with autistic spectrum disorders , 2008, Autism : the international journal of research and practice.

[56]  Mark Jensen,et al.  The Effectiveness of Virtual Reality for Dental Pain Control: A Case Study , 2001, Cyberpsychology Behav. Soc. Netw..

[57]  Dong Pyo Jang,et al.  The treatment of fear of flying: a controlled study of imaginal and virtual reality graded exposure therapy , 2002, IEEE Transactions on Information Technology in Biomedicine.

[58]  Charles van der Mast,et al.  Virtual Reality Treatment in Acrophobia: A Comparison with Exposure in Vivo , 2001, Cyberpsychology Behav. Soc. Netw..

[59]  Mel Slater,et al.  Inducing a virtual hand ownership illusion through a brain–computer interface , 2009, Neuroreport.

[60]  Maria V. Sanchez-Vives,et al.  Inducing Illusory Ownership of a Virtual Body , 2009, Front. Neurosci..

[61]  Giuseppe Riva,et al.  Virtual environments in neuroscience , 1998, IEEE Transactions on Information Technology in Biomedicine.

[62]  B. Rothbaum,et al.  A pilot and feasibility study of virtual reality as a distraction for children with cancer. , 2004, Journal of the American Academy of Child and Adolescent Psychiatry.

[63]  A. Rizzo,et al.  Virtual reality in paediatric rehabilitation: A review , 2009, Developmental neurorehabilitation.

[64]  Robert S. Kennedy,et al.  Simulator Sickness Questionnaire: An enhanced method for quantifying simulator sickness. , 1993 .

[65]  Matthew S. Goodwin,et al.  Enhancing and Accelerating the Pace of Autism Research and Treatment , 2008 .

[66]  Susan Toth-Cohen,et al.  Development and Evaluation of Health and Wellness Exhibits at the Jefferson Occupational Therapy Education Center in Second Life , 2009 .

[67]  R McCloy,et al.  Virtual reality in surgery , 2001, BMJ : British Medical Journal.

[68]  Cristina Botella,et al.  Redefining Therapeutic Success with Virtual Reality Exposure Therapy , 2001, Cyberpsychology Behav. Soc. Netw..

[69]  A EhrlichJustin,et al.  A virtual environment for teaching social skills , 2009 .

[70]  J. Dankelman,et al.  Transfer validity of laparoscopic knot-tying training on a VR simulator to a realistic environment: A randomized controlled trial , 2008, Surgical Endoscopy.

[71]  M. Jensen,et al.  Applications of virtual reality for pain management in burn-injured patients , 2008, Expert review of neurotherapeutics.

[72]  Sarah Parsons,et al.  The Use and Understanding of Virtual Environments by Adolescents with Autistic Spectrum Disorders , 2004, Journal of autism and developmental disorders.

[73]  G. Riva,et al.  Virtual reality for the treatment of body image disturbances. , 1997, Studies in health technology and informatics.

[74]  J. Norris,et al.  The Growth and Direction of Healthcare Support Groups in Virtual Worlds , 2009 .

[75]  G. Riva,et al.  Being There: Concepts, Effects and Measurements of User Presence in Synthetic Environments , 2003 .

[76]  J. McComas,et al.  Current uses of virtual reality for children with disabilities. , 1998, Studies in health technology and informatics.

[77]  Patrick G. Kenny,et al.  Virtual Reality Goes to War: A Brief Review of the Future of Military Behavioral Healthcare , 2011, Journal of Clinical Psychology in Medical Settings.

[78]  T. Furness,et al.  Virtual reality as an adjunctive pain control during burn wound care in adolescent patients , 2000, Pain.

[79]  Andrea Gaggioli,et al.  Virtual Worlds, Real Healing , 2007, Science.

[80]  Richard M. Satava,et al.  Medical applications of virtual reality , 1997, CACM.

[81]  T. Anguera,et al.  From Communication to Presence: Cognition, emotions and culture towards the ultimate communicative experience , 2006 .

[82]  Rajesh Aggarwal,et al.  Proving the Effectiveness of Virtual Reality Simulation for Training in Laparoscopic Surgery , 2007, Annals of surgery.

[83]  R. Aggarwal,et al.  Systematic review of randomized controlled trials on the effectiveness of virtual reality training for laparoscopic surgery , 2008, The British journal of surgery.

[84]  P. Hut,et al.  Avatars Are For Real: Virtual Communities and Public Spheres , 2008 .

[85]  Xiaoli Yang,et al.  Script language for avatar animation in 3D virtual environments , 2003, IEEE International Symposium on Virtual Environments, Human-Computer Interfaces and Measurement Systems, 2003. VECIMS '03. 2003.

[86]  B. Rothbaum,et al.  Virtual reality exposure therapy for Vietnam veterans with posttraumatic stress disorder. , 2001, The Journal of clinical psychiatry.

[87]  Wijnand A. IJsselsteijn,et al.  Toward a Core Bibliography of Presence , 2001, Cyberpsychology Behav. Soc. Netw..

[88]  Robert M Sweet,et al.  Virtual reality as an adjunctive pain control during transurethral microwave thermotherapy. , 2005, Urology.

[89]  Emil M. Petriu,et al.  Capturing Behaviour for the Use of Avatars in Virtual Environments , 2003, Cyberpsychology Behav. Soc. Netw..

[90]  Larry F. Hodges,et al.  Virtual reality exposure therapy abbreviated treatment manual: Fear of flying application , 1999 .

[91]  R. Satava,et al.  Virtual reality in medicine , 1999 .

[92]  G. Riva,et al.  Communications Through Virtual Technologies: Identity, Community and Technology in the Communication Age , 2001 .

[93]  Inocencio Maramba,et al.  Pitfalls in 3-D Virtual Worlds Health Project Evaluations: The Trap of Drug-trial-style Media Comparative Studies , 2009 .

[94]  B. Rothbaum,et al.  Virtual Reality Exposure Therapy for PTSD Vietnam Veterans: A Case Study , 1999, Journal of traumatic stress.

[95]  A. Rizzo,et al.  Affective outcomes of virtual reality exposure therapy for anxiety and specific phobias: a meta-analysis. , 2008, Journal of behavior therapy and experimental psychiatry.

[96]  Mariano Alcañiz Raya,et al.  Affective Interactions Using Virtual Reality: The Link between Presence and Emotions , 2007, Cyberpsychology Behav. Soc. Netw..

[97]  G. Riva,et al.  Virtual Reality in Neuro-Psycho-Physiology: Cognitive, Clinical and Methodological Issues in Assessment and Treatment , 1997 .

[98]  S. Botden,et al.  What is going on in augmented reality simulation in laparoscopic surgery? , 2008, Surgical Endoscopy.

[99]  Giuseppe Riva,et al.  Virtual-reality-based multidimensional therapy for the treatment of body image disturbances in binge eating disorders: a preliminary controlled study , 2002, IEEE Transactions on Information Technology in Biomedicine.

[100]  Lakshmi Sastry,et al.  Virtual environments for engineering applications , 1998, Virtual Reality.

[101]  Frederick P. Brooks.  What's Real About Virtual Reality? , 1999, IEEE Computer Graphics and Applications.

[102]  G. Ferlin,et al.  PET Supports the Hypothesized Existence of a Male Sexual Brain Algorithm that May Respond to Treatment Combining Psychotherapy with Virtual Reality , 1999, Cyberpsychology Behav. Soc. Netw..

[103]  Brenda K. Wiederhold,et al.  Fear of Flying: A Case Report Using Virtual Reality Therapy with Physiological Monitoring , 1998, Cyberpsychology Behav. Soc. Netw..

[104]  G. Optale,et al.  Multimedia and virtual reality techniques in the treatment of male erectile disorders , 1997, International Journal of Impotence Research.

[105]  Jacob Cohen,et al.  A power primer. , 1992, Psychological bulletin.

[106]  M. North,et al.  Virtual reality therapy for fear of flying. , 1997, The American journal of psychiatry.

[107]  G. Riva,et al.  A Second Life for eHealth: Prospects for the Use of 3-D Virtual Worlds in Clinical Psychology , 2008, Journal of medical Internet research.

[108]  Andrea Giachetti,et al.  An integrated simulator for surgery of the petrous bone. , 2001, Studies in health technology and informatics.

[109]  P N Wilson,et al.  Uses of virtual reality in clinical training: developing the spatial skills of children with mobility impairments. , 1998, Studies in health technology and informatics.

[110]  Richard M. Satava,et al.  Medical applications of virtual reality , 1995, Journal of Medical Systems.

[111]  F. Biocca,et al.  Communication in the age of virtual reality , 1995 .

[112]  B. Rothbaum,et al.  A controlled study of virtual reality exposure therapy for the fear of flying. , 2000, Journal of consulting and clinical psychology.

[113]  Teodor P Grantcharov,et al.  Learning curves and impact of previous operative experience on performance on a virtual reality simulator to test laparoscopic surgical skills. , 2003, American journal of surgery.

[114]  D Strickland,et al.  Virtual reality for the treatment of autism. , 1997, Studies in health technology and informatics.

[115]  K. Wilson,et al.  A Survey of Health-Related Activities on Second Life , 2009, Journal of medical Internet research.

[116]  V. González.  Towards a virtual doctor-patient relationship: Understanding virtual patients. , 2009 .

[117]  Albert A. Rizzo,et al.  Initial Validation of a Virtual Environment for Assessment of Memory Functioning: Virtual Reality Cognitive Performance Assessment Test , 2008, Cyberpsychology Behav. Soc. Netw..

[118]  Albert A. Rizzo,et al.  Virtual Reality in Brain Damage Rehabilitation: Review , 2005, Cyberpsychology Behav. Soc. Netw..

[119]  L J Whalley,et al.  Ethical issues in the application of virtual reality to medicine. , 1995, Computers in biology and medicine.

[120]  Maged N Kamel Boulos,et al.  The University of Plymouth Sexual Health SIM experience in Second Life: evaluation and reflections after 1 year. , 2009, Health information and libraries journal.

[121]  Steve Wheeler,et al.  Second Life: an overview of the potential of 3-D virtual worlds in medical and health education. , 2007, Health information and libraries journal.

[122]  Virtual Iraq/Afghanistan and how it is helping some Troops and Vets with PTSD , 2010 .

[123]  Eric J. Seibel,et al.  Virtual Reality as an Adjunctive Non-pharmacologic Analgesic for Acute Burn Pain During Medical Procedures , 2011, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[124]  G. Riva.  Virtual environment for body image modification: virtual reality system for the treatment of body image disturbances , 1998 .

[125]  E. A. Attree,et al.  Virtual Environments in the Diagnosis, Prevention, and Intervention of Age-Related Diseases: A Review of VR Scenarios Proposed in the EC VETERAN Project , 1999, Cyberpsychology Behav. Soc. Netw..

[126]  Giuseppe Riva,et al.  Virtual Reality in Psychotherapy: Review , 2005, Cyberpsychology Behav. Soc. Netw..

[127]  Hunter G Hoffman,et al.  The Analgesic Effects of Opioids and Immersive Virtual Reality Distraction: Evidence from Subjective and Functional Brain Imaging Assessments , 2007, Anesthesia and analgesia.

[128]  Giuseppe Riva,et al.  Six-Month Follow-Up of In-Patient Experiential Cognitive Therapy for Binge Eating Disorders , 2003, Cyberpsychology Behav. Soc. Netw..

[129]  Jonathan Steuer,et al.  Defining virtual reality: dimensions determining telepresence , 1992 .

[130]  Hunter G. Hoffman,et al.  Manipulating presence influences the magnitude of virtual reality analgesia , 2004, Pain.

[131]  Sarah Nichols,et al.  Health and safety implications of virtual reality: a review of empirical evidence. , 2002, Applied ergonomics.

[132]  P. Mitchell,et al.  The potential of virtual reality in social skills training for people with autistic spectrum disorders. , 2002, Journal of intellectual disability research : JIDR.

[133]  Concepción Perpiñá,et al.  A New Realistic 3D Body Representation in Virtual Environments for the Treatment of Disturbed Body Image in Eating Disorders , 2000, Cyberpsychology Behav. Soc. Netw..

[134]  G. Riva,et al.  Virtual reality in anxiety disorders: the past and the future , 2008, Expert review of neurotherapeutics.

[135]  Albert A. Rizzo,et al.  Analysis of assets for virtual reality applications in neuropsychology , 2004 .

[136]  James R. Miller,et al.  A Virtual Environment for Teaching Social Skills: AViSSS , 2009, IEEE Computer Graphics and Applications.

[137]  Susan M. Schneider,et al.  Effect of virtual reality on time perception in patients receiving chemotherapy , 2011, Supportive Care in Cancer.

[138]  Giuseppe Riva,et al.  The need for a socio-cultural perspective in the implementation of virtual environments , 2000, Virtual Reality.

[139]  Jay D. Mabrey,et al.  SYMPOSIUM: ABJS CARL T. BRIGHTON WORKSHOP ON HEALTH INFORMATICS Virtual Reality in Orthopaedics , 2010 .

[140]  D. Reid,et al.  Virtual Reality in Pediatric Neurorehabilitation: Attention Deficit Hyperactivity Disorder, Autism and Cerebral Palsy , 2010, Neuroepidemiology.

[141]  Jennifer Martin.  Consuming Code: Use-Value, Exchange-Value, and the Role of Virtual Goods in Second Life , 2008 .

[142]  G Optale,et al.  PET supports the hypothesized existence of a male sexual brain algorithm which may respond to treatment combining psychotherapy with virtual reality. , 1999, Studies in health technology and informatics.

[143]  Jun Ye,et al.  Exploring the social competence of students with autism spectrum conditions in a collaborative virtual learning environment - The pilot study , 2010, Comput. Educ..

[144]  G Riva,et al.  A VR-based multicomponent treatment for panic disorders with agoraphobia. , 2001, Studies in health technology and informatics.

[145]  Andrea Gaggioli,et al.  NeuroVR 2 - A Free Virtual Reality Platform for the Assessment and Treatment in Behavioral Health Care , 2011, MMVR.

[146]  Leif Hedman,et al.  Proficiency-based virtual reality training significantly reduces the error rate for residents during their first 10 laparoscopic cholecystectomies. , 2007, American journal of surgery.

[147]  Susannah Fox.  Finding Answers Online in Sickness and in Health , 2006 .

[148]  P. King.  Virtual reality technology, 2nd edition - Book Review , 2004, IEEE Engineering in Medicine and Biology Magazine.

[149]  K. Kobak,et al.  Behavioral versus pharmacological treatments of obsessive compulsive disorder: a meta-analysis , 1998, Psychopharmacology.

[150]  M. Heim.  Virtual Realism , 1998 .

[151]  Giuseppe Riva,et al.  Virtual Reality-Based Multidimensional Therapy for the Treatment of Body Image Disturbances in Obesity: A Controlled Study , 2001, Cyberpsychology Behav. Soc. Netw..