Does Sonographic Needle Guidance Affect the Clinical Outcome of Intraarticular Injections?

Objective. This randomized controlled study addressed whether sonographic needle guidance affected clinical outcomes of intraarticular (IA) joint injections. Methods. In total, 148 painful joints were randomized to IA triamcinolone acetonide injection by conventional palpation-guided anatomic injection or sonographic image-guided injection enhanced with a one-handed control syringe (the reciprocating device). A one-needle, 2-syringe technique was used, where the first syringe was used to introduce the needle, aspirate any effusion, and anesthetize and dilate the IA space with lidocaine. After IA placement and synovial space dilation were confirmed, a syringe exchange was performed, and corticosteroid was injected with the second syringe through the indwelling IA needle. Baseline pain, procedural pain, pain at outcome (2 weeks), and changes in pain scores were measured with a 0–10 cm visual analog pain scale (VAS). Results. Relative to conventional palpation-guided methods, sonographic guidance resulted in 43.0% reduction in procedural pain (p < 0.001), 58.5% reduction in absolute pain scores at the 2 week outcome (p < 0.001), 75% reduction in significant pain (VAS pain score ≥ 5 cm; p < 0.001), 25.6% increase in the responder rate (reduction in VAS score ≥ 50% from baseline; p < 0.01), and 62.0% reduction in the nonresponder rate (reduction in VAS score < 50% from baseline; p < 0.01). Sonography also increased detection of effusion by 200% and volume of aspirated fluid by 337%. Conclusion. Sonographic needle guidance significantly improves the performance and outcomes of outpatient IA injections in a clinically significant manner.

[1]  H. Bliddal,et al.  Intra-articular distribution pattern after ultrasound-guided injections in wrist joints of patients with rheumatoid arthritis. , 2009, European journal of radiology.

[2]  W. Grassi,et al.  Modern imaging techniques: a revolution for rheumatology practice. , 2008, Best practice & research. Clinical rheumatology.

[3]  Peter Sögner,et al.  Feasibility of ultrasound-guided sacroiliac joint injection considering sonoanatomic landmarks at two different levels in cadavers and patients. , 2008, Arthritis and rheumatism.

[4]  L. Kiemeney,et al.  Glenohumeral joint injection: a comparative study of ultrasound and fluoroscopically guided techniques before MR arthrography , 2008, European Radiology.

[5]  E. Bedrick,et al.  A randomized, controlled trial of the reciprocating procedure device for local anesthesia. , 2008, Journal of Emergency Medicine.

[6]  J. Natour,et al.  Ultrasound-guided intra-articular injections in the wrist in patients with rheumatoid arthritis: a double-blind, randomised controlled study , 2008, Annals of the rheumatic diseases.

[7]  A. Iagnocco,et al.  Imaging Ultrasound imaging for the rheumatologist XVI . Ultrasound-guided procedures , 2006 .

[8]  A. Bankhurst,et al.  Patient pain and tissue trauma during syringe procedures: a randomized controlled trial. , 2008, The Journal of rheumatology.

[9]  L. Louis Musculoskeletal ultrasound intervention: principles and advances. , 2008, Radiologic clinics of North America.

[10]  H. Bliddal,et al.  Clinical outcome and imaging changes after intraarticular (IA) application of etanercept or methylprednisolone in rheumatoid arthritis: magnetic resonance imaging and ultrasound-Doppler show no effect of IA injections in the wrist after 4 weeks. , 2008, The Journal of rheumatology.

[11]  M. Awerbuch The clinical utility of ultrasonography for rotator cuff disease, shoulder impingement syndrome and subacromial bursitis , 2008, The Medical journal of Australia.

[12]  D. Kane,et al.  A modular, flexible training strategy to achieve competence in diagnostic and interventional musculoskeletal ultrasound in patients with hip osteoarthritis. , 2007, Rheumatology.

[13]  O. Sander Intra-articular corticosteroid injections with the reciprocating procedure device reduced procedural pain and duration more than the conventional syringe , 2007, Evidence-based medicine.

[14]  M. Yunus,et al.  Techniques for "blind" glucocorticosteroid injections into glenohumeral joints. , 2007, The Journal of rheumatology.

[15]  M. Esenyel,et al.  Comparison of four different intra-articular injection sites in the knee: a cadaver study , 2007, Knee Surgery, Sports Traumatology, Arthroscopy.

[16]  Mark A. Pollard,et al.  Accuracy of injection into the basal joint of the thumb. , 2007, American journal of orthopedics.

[17]  P. Emery,et al.  The development of an evidence-based educational framework to facilitate the training of competent rheumatologist ultrasonographers. , 2007, Rheumatology.

[18]  D. Rivero,et al.  Reduced Pain of Intraarticular Hyaluronate Injection With the Reciprocating Procedure Device , 2007, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

[19]  Craig S. Wong,et al.  Needle Phobia and Stress-Reducing Medical Devices in Pediatric and Adult Chemotherapy Patients , 2007, Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses.

[20]  A. Bankhurst,et al.  Control and performance characteristics of eight different suction biopsy devices. , 2006, Journal of vascular and interventional radiology : JVIR.

[21]  D. Adams,et al.  Impact of safety needle devices on occupationally acquired needlestick injuries: a four-year prospective study. , 2006, The Journal of hospital infection.

[22]  H. Draeger,et al.  Patients with needle phobia? Try stress-reducing medical devices. , 2006, The Journal of family practice.

[23]  J. Katz,et al.  Can the carpometacarpal joint be injected accurately in the office setting? Implications for therapy. , 2006, The Journal of rheumatology.

[24]  N. Hanchard,et al.  Accuracy and dispersal of subacromial and glenohumeral injections in cadavers. , 2006, The Journal of rheumatology.

[25]  H. Draeger,et al.  Physician control of needle and syringe during aspiration-injection procedures with the new reciprocating syringe. , 2006, The Journal of rheumatology.

[26]  R. Nelissen,et al.  The accuracy of subacromial injections: a prospective randomized magnetic resonance imaging study. , 2006, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[27]  M. Yunus,et al.  Accuracy of intra-articular injection of the glenohumeral joint: a cadaveric study. , 2006, Orthopedics.

[28]  Metin Ozalay,et al.  Accuracy and Outcome of Sonographically Guided Intra‐articular Sodium Hyaluronate Injections in Patients With Osteoarthritis of the Hip , 2005, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[29]  J. Natour,et al.  Polyarticular corticosteroid injection versus systemic administration in treatment of rheumatoid arthritis patients: a randomized controlled study. , 2005, The Journal of rheumatology.

[30]  Rebecca S Lewis,et al.  Relative procedure intensity with self-referral and radiologist referral: extremity radiography. , 2005, Radiology.

[31]  Andrew K. Brown,et al.  Recommendations for musculoskeletal ultrasonography by rheumatologists: setting global standards for best practice by expert consensus. , 2005, Arthritis and rheumatism.

[32]  J. Sunshine,et al.  Who gets paid for diagnostic imaging, and how much? , 2004, Journal of the American College of Radiology.

[33]  R. Buchbinder,et al.  Do imaging methods that guide needle placement improve outcome? , 2004, Annals of the rheumatic diseases.

[34]  W. Grassi,et al.  Musculoskeletal Ultrasound: A State of the Art Review in Rheumatology. Part I: Current Controversies and Issues in the Development of Musculoskeletal Ultrasound in Rheumatology , 2004, Rheumatology.

[35]  J. Read,et al.  Sonographically guided glenohumeral joint injection. , 2004, AJR. American journal of roentgenology.

[36]  E. Naredo,et al.  A randomized comparative study of short term response to blind injection versus sonographic-guided injection of local corticosteroids in patients with painful shoulder. , 2004, The Journal of rheumatology.

[37]  C. Gordon,et al.  Ultrasound guidance allows accurate needle placement and aspiration from small joints in patients with early inflammatory arthritis. , 2003, Rheumatology.

[38]  D. Kane,et al.  Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis. , 2003, The Journal of rheumatology.

[39]  G. Koren,et al.  Evaluation of eutectic lidocaine/prilocaine cream (EMLA) for steroid joint injection in children with juvenile rheumatoid arthritis: a double blind, randomized, placebo controlled trial. , 2003, The Journal of rheumatology.

[40]  I. McInnes,et al.  Ultrasound guided versus conventional joint and soft tissue fluid aspiration in rheumatology practice: a pilot study. , 2002, The Journal of rheumatology.

[41]  Kotaro Yamakado,et al.  The targeting accuracy of subacromial injection to the shoulder: an arthrographic evaluation. , 2002, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[42]  D. W. Jackson,et al.  Accuracy of Needle Placement into the Intra-Articular Space of the Knee , 2002, The Journal of bone and joint surgery. American volume.

[43]  R. Adler,et al.  Ultrasound-guided interventions in the foot and ankle. , 2002, Seminars in musculoskeletal radiology.

[44]  P. Bearcroft,et al.  Musculoskeletal sonography by rheumatologists: the challenges. , 2002, Rheumatology.

[45]  P. Emery,et al.  The impact of ultrasonography on diagnosis and management of patients with musculoskeletal conditions. , 2001, Arthritis and rheumatism.

[46]  H. Bliddal,et al.  Guidance by ultrasound of intra-articular injections in the knee and hip joints. , 2001, Osteoarthritis and cartilage.

[47]  U. Fredberg,et al.  Placement of intra-articular injections verified by ultrasonography and injected air as contrast medium , 2001, Annals of the rheumatic diseases.

[48]  W. Grassi,et al.  Sonographically guided procedures in rheumatology. , 2001, Seminars in arthritis and rheumatism.

[49]  J. Koski Ultrasound guided injections in rheumatology. , 2000, The Journal of rheumatology.

[50]  M. Dougados,et al.  Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: results of a multicenter, randomized, controlled trial. , 1999, Arthritis and rheumatism.

[51]  B. W. Carson,et al.  Ultrasonographic guidance for injections of local steroids in the native hip. , 1999, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[52]  P. Partington,et al.  Diagnostic injection around the shoulder: hit and miss? A cadaveric study of injection accuracy. , 1998, Journal of shoulder and elbow surgery.

[53]  P. Melloni,et al.  Sonographic guidance of needle position for MR arthrography of the shoulder. , 1997, AJR. American journal of roentgenology.

[54]  B. Bresnihan,et al.  Comparison of the accuracy of steroid placement with clinical outcome in patients with shoulder symptoms , 1997, Annals of the rheumatic diseases.

[55]  C W Hayes,et al.  Dry taps and what to do about them: a pictorial essay on failed arthrocentesis of the knee. , 1996, The American journal of medicine.

[56]  R. Lindsay,et al.  The systemic effect of intraarticular administration of corticosteroid on markers of bone formation and bone resorption in patients with rheumatoid arthritis. , 1996, Arthritis and rheumatism.

[57]  M. Regan,et al.  Importance of placement of intra-articular steroid injections. , 1993, BMJ.

[58]  D G Ferris,et al.  Measurement of subjective phenomena in primary care research: the Visual Analogue Scale. , 1993, Family practice research journal.

[59]  G. Firestein,et al.  Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids. , 1991, Arthritis and rheumatism.

[60]  C. Warfield,et al.  The measurement of pain. , 1988, Hospital practice.

[61]  H. Möllmann,et al.  Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra‐articular administration , 1986, Clinical pharmacology and therapeutics.

[62]  Jay Smith,et al.  Ultrasound-guided intra-articular injection of the trapeziometacarpal joint: description of technique. , 2008, Archives of physical medicine and rehabilitation.

[63]  H. Draeger,et al.  A randomized controlled trial of the reciprocating procedure device for intraarticular injection of corticosteroid. , 2007, The Journal of rheumatology.

[64]  A. Iagnocco,et al.  Ultrasound imaging for the rheumatologist. , 2006, Clinical and experimental rheumatology.

[65]  P. Sethi,et al.  Accuracy of intra-articular injection of the glenohumeral joint: a cadaveric study. , 2006, Orthopedics.

[66]  I Cavazzana,et al.  Mechanisms of immune-mediated skin diseases: an overview. , 2006, Clinical and experimental rheumatology.

[67]  P. Sethi,et al.  Accuracy of anterior intra-articular injection of the glenohumeral joint. , 2005, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[68]  N. Bellamy,et al.  Intraarticular corticosteroid for treatment of osteoarthritis of the knee. , 2005, The Cochrane database of systematic reviews.

[69]  M. Esenyel,et al.  [The correlation between the accuracy of steroid injections and subsequent shoulder pain and function in subacromial impingement syndrome]. , 2003, Acta orthopaedica et traumatologica turcica.

[70]  J. H. Post Accuracy of needle placement into the intra-articular space of the knee. , 2003, The Journal of bone and joint surgery. American volume.

[71]  R. Adler,et al.  Use of ultrasonographic guidance in interventional musculoskeletal procedures: a review from a single institution. , 2001, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.