COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
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H. Schlüter | J. Izbicki | M. Jücker | Astrid Drenckhan | F. Ewald | C. Wagener | K. Grupp | M. Bockhorn | C. Güngör | P. Lange | A. T. El Gammal | G. Wolters-Eisfeld | S. Harder | B. Hofmann | B. Mercanoglu | Laura Schlüter | A. Fölster | Aeint-Steffen Picksak | Bianca T Hofmann
[1] Richard D Cummings,et al. Protein glycosylation in cancer. , 2015, Annual review of pathology.
[2] J. Izbicki,et al. ABO Blood Group IgM Isoagglutinins Interact with Tumor-Associated O-Glycan Structures in Pancreatic Cancer , 2014, Clinical Cancer Research.
[3] J. Olsen,et al. Immature truncated O-glycophenotype of cancer directly induces oncogenic features , 2014, Proceedings of the National Academy of Sciences.
[4] Po-Huang Lee,et al. The molecular chaperone cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK , 2014, Molecular carcinogenesis.
[5] P. Jha,et al. Correction: Factors Associated with Physician Agreement on Verbal Autopsy of over 11500 Injury Deaths in India , 2013, PLoS ONE.
[6] K. David,et al. Combined targeting of AKT and mTOR using MK‐2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma , 2013, International journal of cancer.
[7] Helene K Myrvang,et al. Protein interactions between surface annexin A2 and S100A10 mediate adhesion of breast cancer cells to microvascular endothelial cells , 2013, FEBS letters.
[8] G. Chang,et al. Surface a -Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target , 2013 .
[9] B. Meyer,et al. Tumor-associated Neu5Ac-Tn and Neu5Gc-Tn antigens bind to C-type lectin CLEC10A (CD301, MGL). , 2013, Glycobiology.
[10] S. Brunak,et al. Precision mapping of the human O‐GalNAc glycoproteome through SimpleCell technology , 2013, The EMBO journal.
[11] C. Leclerc,et al. Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer , 2013, Cancer Immunology, Immunotherapy.
[12] P. Argani,et al. Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78 , 2013, Clinical Cancer Research.
[13] R. Cummings,et al. Epigenetic Silencing of the Chaperone Cosmc in Human Leukocytes Expressing Tn Antigen , 2022 .
[14] Xiaowei Wang,et al. PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update , 2011, Nucleic Acids Res..
[15] H. Wandall,et al. Mining the O-glycoproteome using zinc-finger nuclease–glycoengineered SimpleCell lines , 2011, Nature Methods.
[16] A. Tres,et al. Phase III multicenter clinical trial of the sialyl-TN (STn)-keyhole limpet hemocyanin (KLH) vaccine for metastatic breast cancer. , 2011, The oncologist.
[17] C. Borrebaeck,et al. A new murine IgG1 anti-Tn monoclonal antibody with in vivo anti-tumor activity. , 2011, Glycobiology.
[18] J. Izbicki,et al. Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer. , 2011, Cancer research.
[19] K. Taniuchi,et al. Overexpression of GalNAc-transferase GalNAc-T3 Promotes Pancreatic Cancer Cell Growth , 2011, Oncogene.
[20] Yusuke Nakamura,et al. Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin. , 2011, Neoplasia.
[21] Henrik Clausen,et al. Location, location, location: new insights into O-GalNAc protein glycosylation. , 2011, Trends in cell biology.
[22] B. Xia,et al. A novel fluorescent assay for T-synthase activity. , 2011, Glycobiology.
[23] Jeremy C. Collette,et al. Emerging Paradigms for the Initiation of Mucin-type Protein O-Glycosylation by the Polypeptide GalNAc Transferase Family of Glycosyltransferases* , 2011, The Journal of Biological Chemistry.
[24] R. Cummings,et al. The Tn Antigen—Structural Simplicity and Biological Complexity , 2011, Angewandte Chemie.
[25] A. Hovanessian,et al. Surface Expressed Nucleolin Is Constantly Induced in Tumor Cells to Mediate Calcium-Dependent Ligand Internalization , 2010, PloS one.
[26] Douglas B. Evans,et al. High Levels of Nucleolar Expression of Nucleolin Are Associated with Better Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma , 2010, Clinical Cancer Research.
[27] R. Simon,et al. Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung , 2010, BMC Cancer.
[28] Leonor David,et al. Alterations in glycosylation as biomarkers for cancer detection , 2010, Journal of Clinical Pathology.
[29] Giovanni Parmigiani,et al. Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers , 2009, Proceedings of the National Academy of Sciences.
[30] A. Scarpa,et al. An integrated humoral and cellular response is elicited in pancreatic cancer by α‐enolase, a novel pancreatic ductal adenocarcinoma‐associated antigen , 2009, International journal of cancer.
[31] M. Anver,et al. Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines , 2009, Molecular Cancer Therapeutics.
[32] T. Irimura,et al. A lectin recognizes differential arrangements of O-glycans on mucin repeats. , 2008, Biochemical and biophysical research communications.
[33] B. Xia,et al. Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc (Cancer Research (2008) 68, (1636-1646)) , 2008 .
[34] B. Xia,et al. Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc. , 2008, Cancer research.
[35] Henrik Clausen,et al. Mucin-type O-glycosylation and its potential use in drug and vaccine development. , 2008, Biochimica et biophysica acta.
[36] H. Müller-Hermelink,et al. A new tumor-specific variant of GRP78 as target for antibody-based therapy , 2008, Laboratory Investigation.
[37] G. Cavet,et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL , 2007, Nature Medicine.
[38] E. Bennett,et al. Immunolocalisation of members of the polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer. , 2007, Acta histochemica.
[39] G. Meijer,et al. The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma , 2007, Cancer Immunology, Immunotherapy.
[40] M. Morris,et al. A polyvalent vaccine for high-risk prostate patients: “are more antigens better?” , 2007, Cancer Immunology, Immunotherapy.
[41] F. Real,et al. Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2. , 2007, The American journal of pathology.
[42] Maido Remm,et al. Enhancements and modifications of primer design program Primer3 , 2007, Bioinform..
[43] G. Soma,et al. Expression of Tn and sialyl-Tn antigens in endometrial cancer: its relationship with tumor-produced cyclooxygenase-2, tumor-infiltrated lymphocytes and patient prognosis. , 2006, Anticancer research.
[44] P. Azadi,et al. A Mutant Chaperone Converts a Wild-Type Protein into a Tumor-Specific Antigen , 2006, Science.
[45] I. Brockhausen,et al. Mucin‐type O‐glycans in human colon and breast cancer: glycodynamics and functions , 2006, EMBO reports.
[46] R. Cummings,et al. Protein glycosylation: Chaperone mutation in Tn syndrome , 2005, Nature.
[47] S. Chierici,et al. Chemoselective assembly and immunological evaluation of multiepitopic glycoconjugates bearing clustered Tn antigen as synthetic anticancer vaccines. , 2005, Bioconjugate chemistry.
[48] D. Legrand,et al. Nucleolin undergoes partial N- and O-glycosylations in the extranuclear cell compartment. , 2005, Biochemistry.
[49] G. Courtand,et al. Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration , 2005, Breast Cancer Research and Treatment.
[50] H. Narimatsu,et al. Expression of UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase-12 in Gastric and Colonic Cancer Cell Lines and in Human Colorectal Cancer , 2004, Oncology.
[51] J. Le Pendu,et al. Expression of sialyl-Tn epitopes on β1 integrin alters epithelial cell phenotype, proliferation and haptotaxis , 2004, Journal of Cell Science.
[52] W. Arap,et al. Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. , 2004, Cancer cell.
[53] L. BenMohamed,et al. A Fully Synthetic Therapeutic Vaccine Candidate Targeting Carcinoma-Associated Tn Carbohydrate Antigen Induces Tumor-Specific Antibodies in Nonhuman Primates , 2004, Cancer Research.
[54] R. Cummings,et al. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[55] S. Crawley,et al. Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas. , 2002, Gastroenterology.
[56] A. Nanashima,et al. High serum concentrations of sialyl Tn antigen in carcinomas of the biliary tract and pancreas. , 1999, Journal of hepato-biliary-pancreatic surgery.
[57] Guo‐Jun Zhang,et al. Prognostic relevance of tn expression in Breast Cancer , 1999, Breast cancer.
[58] G. Springer. Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy , 1997, Journal of Molecular Medicine.
[59] K. Hajjar,et al. Interaction of the Fibrinolytic Receptor, Annexin II, with the Endothelial Cell Surface , 1996, The Journal of Biological Chemistry.
[60] T. Terada,et al. Expression of mucin carbohydrate antigens (T, Tn and sialyl Tn) and MUC-1 gene product in intraductal papillary-mucinous neoplasm of the pancreas. , 1996, American journal of clinical pathology.
[61] E. Scanlon,et al. Pancarcinoma T/Tn Antigen Detects Human Carcinoma Long before Biopsy Does and Its Vaccine Prevents Breast Carcinoma Recurrence a , 1993, Annals of the New York Academy of Sciences.
[62] S. Hakomori,et al. Expression of Tn, sialosyl Tn, and T antigens in human pancreas. , 1991, Gastroenterology.
[63] J. Dausset,et al. [Acquired hemolytic anemia with polyagglutinability of erythrocytes by a new factor present in normal blood]. , 1957, Bulletins et memoires de la Societe medicale des hopitaux de Paris.
[64] A. Jemal,et al. Cancer statistics, 2012 , 2012, CA: a cancer journal for clinicians.
[65] C. Borrebaeck,et al. A new murine IgG 1 anti-Tn monoclonal antibody with in vivo anti-tumor activity , 2011 .
[66] A. Furlan,et al. ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity. , 2006, Glycobiology.
[67] H. Makino,et al. Serum sialyl-Tn antigen levels in patients with digestive cancers. , 1991, Oncology.
[68] N. Dubrawsky. Cancer statistics , 1989, CA: a cancer journal for clinicians.