Comparison of the Distribution of Tobramycin and Gentamicin in Body Fluids of Dogs

Tobramycin serum, thoracic lymph, renal lymph, and urine concentrations were measured in mongrel dogs after intravenously administered 5, 10, and 20 mg/kg doses. These were compared with intravenous gentamicin delivered at 5 and 20 mg/kg. Both drugs achieved similar concentrations in serum and thoracic lymph. At 20 mg/kg, tobramycin showed consistently higher renal lymph and urine concentrations than gentamicin. At 5 mg of tobramycin per kg, renal lymph and urine concentrations were higher than with gentamicin only within the 1st h after administration. Thereafter the difference was no longer significant. These data suggest that on the basis of distribution in the body fluids of dogs, tobramycin is a reasonable alternative to gentamicin.

[1]  W. M. Kirby,et al.  Comparative pharmacokinetics of tobramycin and gentamicin , 1973, Clinical pharmacology and therapeutics.

[2]  J. Calnan,et al.  Concentration of Antibacterial Agents in Interstitial Tissue Fluid , 1973, British medical journal.

[3]  M. Keyl,et al.  Summary of renal lymphatic studies. , 1973, The Journal of urology.

[4]  W. Lockwood,et al.  Tobramycin and Gentamicin Concentrations in the Serum of Normal and Anephric Patients , 1973, Antimicrobial Agents and Chemotherapy.

[5]  J. Vernon,et al.  A comparative study of the ototoxicity of tobramycin and gentamicin. , 1972, Archives of otolaryngology.

[6]  W. M. Kirby,et al.  Serum Protein Binding of the Aminoglycoside Antibiotics , 1972, Antimicrobial Agents and Chemotherapy.

[7]  B. Meyers,et al.  Pharmacologic studies on tobramycin and comparison with gentamicin. , 1972, The Journal of clinical pharmacology and new drugs.

[8]  B. Meyers,et al.  Tobramycin: in vitro antibacterial spectrum of a new aminoglycoside. , 1972, The Journal of clinical pharmacology and new drugs.

[9]  R. E. Winters,et al.  Relation between dose and levels of gentamicin in blood. , 1971, The Journal of infectious diseases.

[10]  M. Finland,et al.  Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma. , 1971, The Journal of laboratory and clinical medicine.

[11]  J. Calnan,et al.  The dose, distribution, and excretion of gentamicin with speical reference to renal failure. , 1969, The Journal of infectious diseases.

[12]  N. D. Reis,et al.  Distribution of Gentamicin in Body Fluids , 1968, British medical journal.

[13]  A. Cockett,et al.  Distribution of some newer antibiotics within the kidney interstitium: a therapeutic consideration in pyelonephritis. , 1967, Investigative urology.

[14]  A. Cockett,et al.  Significance of Antibacterial Levels in the Renal Lymph During Treatment for Pyelonephritis , 1966 .

[15]  C. K. Drinker,et al.  THE PROTEIN CONTENT OF MAMMALIAN LYMPH AND THE RELATION OF LYMPH TO TISSUE FLUID , 1931 .

[16]  H. Black,et al.  Preliminary studies with nebramycin factor 6. , 1970, Antimicrobial agents and chemotherapy.

[17]  G. Chisholm,et al.  Renal tissue levels of gentamicin and a dose schedule in renal impairment. , 1969, Therapeutische Umschau. Revue thérapeutique.

[18]  C. E. Higgins,et al.  Nebramycin, a new broad-spectrum antibiotic complex. II. Description of Streptomyces tenebrarius. , 1967, Antimicrobial agents and chemotherapy.

[19]  J. S. Welles,et al.  Nebramycin, a new broad-spectrum antibiotic complex. IV. In vitro and in vivo laboratory evaluation. , 1967, Antimicrobial agents and chemotherapy.

[20]  A. Cockett,et al.  The renal lymphatics and therapy of pyelonephritis. , 1965, British journal of urology.