A Concise Route for the Synthesis of Pyranonaphthoquinone Derivatives
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An efficient synthesis of pyranonaphthoquinones is achieved by ethylenediamine diacetate-catalyzed reactions of 4-hydroxy-2-quinolones with a variety of α,β-unsaturated aldehydes in moderate yields. This method provides arapid entry into biologically interesting α-lapachone derivatives with a variety of substituents on the pyran ring.