Immune Fitness, Migraine, and Headache Complaints in Individuals with Self-Reported Impaired Wound Healing

Background Having chronic wounds and impaired wound healing are associated with psychological distress. The current study aims to evaluate migraine and headache complaints in young adults with self-reported impaired wound healing. Methods A survey was conducted among N=1935 young adults (83.6% women), 18–30 years old, living in the Netherlands. Wound healing status was verified, immune fitness was assessed using a single-item rating scale, and ID Migraine was completed. In addition, several questions were answered on past year’s headache experiences (including frequency, quantity, type, location, and severity). Results In both the control group (p < 0.001) and the IWH group (p = 0.002) immune fitness was significantly lower among those that reported headaches compared to those that reported no headaches. Individuals with self-reported impaired wound healing (IWH) scored significantly higher on the ID Migraine scale, and individuals of the IWH group scored significantly more often positive for migraine (ie, an ID Migraine score ≥2). They reported a younger age of onset of experiencing headaches, and significantly more often reported having a beating or pounding headache than the control group. Compared to the control group, the IWH group reported being significantly more limited in their daily activities compared to the control group. Conclusion Headaches and migraines are more frequently reported by individuals with self-reported impaired wound healing, and their reported immune fitness is significantly poorer compared to healthy controls. These headache and migraine complaints significantly limit them in their daily activities.

[1]  A. Scholey,et al.  Test-retest reliability of single-item assessments of immune fitness, mood, and quality of life. , 2023, Heliyon.

[2]  J. Verster,et al.  The Assessment of Immune Fitness , 2022, Journal of clinical medicine.

[3]  T. Houle,et al.  Lifestyle factors and migraine , 2022, The Lancet Neurology.

[4]  A. Boulton,et al.  [The diabetic foot]. , 2022, Khirurgiia.

[5]  J. Verster,et al.  Insomnia Complaints and Perceived Immune Fitness in Young Adults with and without Self-Reported Impaired Wound Healing , 2022, Medicina.

[6]  J. Verster,et al.  Inattention, Impulsivity, and Hyperactivity among Individuals with Self-Reported Impaired Wound Healing , 2022, Brain sciences.

[7]  J. Verster,et al.  Pandemic Preparedness: Maintaining Adequate Immune Fitness by Attaining a Normal, Healthy Body Weight , 2022, Journal of clinical medicine.

[8]  J. Verster,et al.  Pandemic Preparedness: The Importance of Adequate Immune Fitness , 2022, Journal of clinical medicine.

[9]  J. Verster,et al.  Mental Resilience, Mood, and Quality of Life in Young Adults with Self-Reported Impaired Wound Healing , 2022, International journal of environmental research and public health.

[10]  J. Verster,et al.  Self-Reported Impaired Wound Healing in Young Adults and Their Susceptibility to Experiencing Immune-Related Complaints , 2022, Journal of clinical medicine.

[11]  J. Verster,et al.  The Association of Irritable Bowel Complaints and Perceived Immune Fitness among Individuals That Report Impaired Wound Healing: Supportive Evidence for the Gut–Brain–Skin Axis , 2021, Gastroenterology Insights.

[12]  A. Scholey,et al.  The Impact of Having a Holiday or Work in Fiji on Perceived Immune Fitness , 2021, Tourism and Hospitality.

[13]  C. Kleinschnitz,et al.  Impaired wound healing in a migraine patient as a possible side effect of calcitonin gene-related peptide receptor antibody treatment: A case report , 2020, Cephalalgia : an international journal of headache.

[14]  J. Verster,et al.  Relationship between Alcohol Hangover and Physical Endurance Performance: Walking the Samaria Gorge , 2019, Journal of clinical medicine.

[15]  A. Scholey,et al.  Development and Validation of the Immune Status Questionnaire (ISQ) , 2019, International journal of environmental research and public health.

[16]  C. Sen.  Human Wounds and Its Burden: An Updated Compendium of Estimates. , 2019, Advances in wound care.

[17]  L. Edvinsson,et al.  CGRP as the target of new migraine therapies — successful translation from bench to clinic , 2018, Nature Reviews Neurology.

[18]  J. Verster,et al.  Mental resilience, perceived immune functioning, and health , 2017, Journal of multidisciplinary healthcare.

[19]  V. Appay,et al.  Aging of the immune system: Focus on inflammation and vaccination , 2016, European journal of immunology.

[20]  E. Nisenbaum,et al.  Development of a novel antibody to calcitonin gene-related peptide for the treatment of osteoarthritis-related pain. , 2014, Osteoarthritis and cartilage.

[21]  M. Schmelz,et al.  Epidermal nerve fibers modulate keratinocyte growth via neuropeptide signaling in an innervated skin model. , 2013, The Journal of investigative dermatology.

[22]  T. Fahey,et al.  Diagnostic Accuracy of the ID Migraine: A Systematic Review and Meta‐Analysis , 2011, Headache.

[23]  Y. Kurihara,et al.  Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice. , 2011, American journal of physiology. Heart and circulatory physiology.

[24]  J. Zhuang,et al.  Inhibitory effects of calcitonin gene-related peptides on experimental vein graft disease. , 2010, The Annals of thoracic surgery.

[25]  Amit N. Patel,et al.  Circulating endothelial progenitor cells: a new approach to anti-aging medicine? , 2009, Journal of Translational Medicine.

[26]  J. -. Park,et al.  Decreased number and function of endothelial progenitor cells in patients with migraine , 2008, Neurology.

[27]  P. Leung,et al.  Diabetic foot ulcers--a comprehensive review. , 2007, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[28]  D. Greenhalgh,et al.  Cutaneous Wound Healing , 2007, Journal of burn care & research : official publication of the American Burn Association.

[29]  Stephanie Wu,et al.  Foot ulcers in the diabetic patient, prevention and treatment , 2007, Vascular health and risk management.

[30]  P. Metharom,et al.  Endothelial progenitor cells , 2007 .

[31]  L. Harkless,et al.  Current concepts in diabetic microvascular dysfunction. , 2006, Journal of the American Podiatric Medical Association.

[32]  H. Miller,et al.  Comparative analysis of methods for assessment of circulating endothelial progenitor cells. , 2006, Tissue engineering.

[33]  Thomas K. Borg,et al.  What is the Future of Diabetic Wound Care? , 2006, The Diabetes educator.

[34]  T. Rabelink,et al.  Endothelial progenitor cell dysfunction in type 1 diabetes: another consequence of oxidative stress? , 2005, Antioxidants & redox signaling.

[35]  Jin‐Ho Choi,et al.  Transplantation of Endothelial Progenitor Cells Accelerates Dermal Wound Healing with Increased Recruitment of Monocytes/Macrophages and Neovascularization , 2005, Stem cells.

[36]  W. Malarkey,et al.  Exercise accelerates wound healing among healthy older adults: a preliminary investigation. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[37]  C. Baum,et al.  Normal Cutaneous Wound Healing: Clinical Correlation with Cellular and Molecular Events , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[38]  A. Avogaro,et al.  Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. , 2005, Journal of the American College of Cardiology.

[39]  S. Silberstein.  Migraine Pathophysiology and its Clinical Implications , 2004, Cephalalgia : an international journal of headache.

[40]  M. Herlyn,et al.  Adenoviral mediated gene transfer of PDGF‐B enhances wound healing in type I and type II diabetic wounds , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[41]  Sunyoung Kim,et al.  Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease , 2004, Experimental & Molecular Medicine.

[42]  Robert Goldman,et al.  Growth Factors and Chronic Wound Healing: Past, Present, and Future , 2004, Advances in skin & wound care.

[43]  P. Blume,et al.  Vascular evaluation and arterial reconstruction of the diabetic foot. , 2003, Clinics in podiatric medicine and surgery.

[44]  R. Lipton,et al.  A self-administered screener for migraine in primary care , 2003, Neurology.

[45]  A. Quyyumi,et al.  Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. , 2003, The New England journal of medicine.

[46]  G. Gurtner,et al.  Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures , 2002, Circulation.

[47]  M. Makuuchi,et al.  Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis , 2002, Nature Medicine.

[48]  Anthony Atala,et al.  Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo , 2001, Nature Medicine.

[49]  R. Lipton,et al.  Prevalence and Burden of Migraine in the United States: Data From the American Migraine Study II , 2001, Headache.

[50]  S. Fichtlscherer,et al.  Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease , 2001, Circulation research.

[51]  J. Changeux,et al.  Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in αCGRP-deficient mice , 2001, Nature Neuroscience.

[52]  L. Russell.  The importance of patients' nutritional status in wound healing. , 2001, British journal of nursing.

[53]  B. Rasmussen,et al.  The impact of migraine: Epidemiology, risk factors, and co-morbidities , 2001 .

[54]  K. Westlund,et al.  Arthritic calcitonin/α calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity , 2001, Pain.

[55]  J. Isner,et al.  Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Haruchika Masuda,et al.  Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization , 1999, Nature Medicine.

[57]  S. Rafii,et al.  Evidence for circulating bone marrow-derived endothelial cells. , 1998, Blood.

[58]  J. Olesen,et al.  Nitric Oxide Synthase Inhibition: A New Principle in the Treatment of Migraine Attacks , 1998, Cephalalgia : an international journal of headache.

[59]  Takayuki Asahara,et al.  Isolation of Putative Progenitor Endothelial Cells for Angiogenesis , 1997, Science.

[60]  A. Wysocki.  Wound Fluids and the Pathogenesis of Chronic Wounds , 1996, Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society.

[61]  R. Helme,et al.  Sensory peptides as neuromodulators of wound healing in aged rats. , 1996, The journals of gerontology. Series A, Biological sciences and medical sciences.

[62]  M. Tam,et al.  Vascular skin ulcers of limbs. , 1991, Cardiology clinics.

[63]  P. Goadsby,et al.  Vasoactive peptide release in the extracerebral circulation of humans during migraine headache , 1990, Annals of neurology.

[64]  P. Goadsby,et al.  Recent advances in understanding migraine mechanisms, molecules and therapeutics. , 2007, Trends in molecular medicine.

[65]  M. Rendell,et al.  Manifestations of Cutaneous Diabetic Microangiopathy , 2005, American journal of clinical dermatology.

[66]  C. Baum,et al.  Normal Cutaneous Wound Healing , 2005 .

[67]  Frank J T Staal,et al.  Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. , 2004, Diabetes.

[68]  M. Goodell,et al.  Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. , 2003, The Journal of clinical investigation.