Entorhinal cortex of the mouse: Cytoarchitectonical organization

The present study describes the cytoarchitectonical and chemoarchitectonical organization of the entorhinal cortex of the mouse (C57BL/6J strain). The entorhinal cortex is medially bordered by the parasubiculum, and laterally by the perirhinal cortex; rostrally and medially it is bordered by the piriform cortex, whereas caudally and dorsally it is bordered by the postrhinal cortex. The entorhinal cortex is divided into two main areas, i.e., the lateral entorhinal area (LEA) and the medial entorhinal area (MEA). Both entorhinal areas are further divided into subfields, i.e., LEA is divided into DLE (dorsolateral entorhinal field), DIE (dorsal intermediate entorhinal field), and VIE (ventral intermediate entorhinal field), whereas MEA is divided into CE (caudal entorhinal field) and ME (medial entorhinal field). Cytoarchitectonically, the main difference between LEA and MEA is displayed by layer II neurons: while these are in a dense layer in LEA, they are more dispersed in MEA. Further, in LEA there is a relatively cell‐free zone between layers II and III; this zone is not present in MEA. Histochemically, in acetylcholinesterase (AChE)‐stained material, MEA is characterized by darker‐stained bands in the superficial layer (i.e., layer I) and in the lamina dissecans, in contrast to LEA, which is more evenly stained for AChE. Further, both the border with the perirhinal cortex and the border with the parasubiculum are characterized by dark‐stained bands of AChE. The border between the entorhinal cortex and perirhinal cortex is also easily distinguished in parvalbumin‐stained material; while the entorhinal cortex is darkly stained, the perirhinal cortex is lightly stained. In contrast, in sections stained for calretinin, the entorhinal cortex is more lightly stained than the parasubiculum, which has a darkly stained superficial layer, and a densely stained group of neurons in layer III. Hippocampus 2001;11:397–407. © 2001 Wiley‐Liss, Inc.

[1]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[2]  J. Rawlins,et al.  The effects of NMDA‐induced retrohippocampal lesions on performance of four spatial memory tasks known to be sensitive to hippocampal damage in the rat , 1999, The European journal of neuroscience.

[3]  M. Witter,et al.  Entorhinal cortex of the rat: Cytoarchitectonic subdivisions and the origin and distribution of cortical efferents , 1998, Hippocampus.

[4]  Mnh,et al.  Histologie du Système Nerveux de Lʼhomme et des Vertébrés , 1998 .

[5]  D. Amaral,et al.  Entorhinal cortex of the rat: Organization of intrinsic connections , 1998, The Journal of comparative neurology.

[6]  D. Amaral,et al.  Entorhinal cortex of the rat: Topographic organization of the cells of origin of the perforant path projection to the dentate gyrus , 1998, The Journal of comparative neurology.

[7]  D. Amaral,et al.  Perirhinal and postrhinal cortices of the rat: Interconnectivity and connections with the entorhinal cortex , 1998, The Journal of comparative neurology.

[8]  J. Barnes,et al.  Evidence for recovery of spatial learning following entorhinal cortex lesions in mice , 1997, Brain Research.

[9]  J. Pérez‐clausell Distribution of terminal fields stained for zinc in the neocortex of the rat , 1996, Journal of Chemical Neuroanatomy.

[10]  T. Kosaka,et al.  The distribution of two calcium binding proteins, calbindin D-28K and parvalbumin, in the entorhinal cortex of the adult mouse , 1996, Neuroscience Research.

[11]  R. Jaffard,et al.  Spatial Location Learning in Mice with Ibotenate Lesions of Entorhinal Cortex or Subiculum , 1995, Neurobiology of Learning and Memory.

[12]  R. Insausti,et al.  The human entorhinal cortex: A cytoarchitectonic analysis , 1995, The Journal of comparative neurology.

[13]  T. Kosaka,et al.  Distribution of the calcium binding proteins, calbindin D-28K and parvalbumin, in the subicular complex of the adult mouse , 1995, Neuroscience Research.

[14]  M. Witter,et al.  Parvalbumin-immunoreactive neurons in the entorhinal cortex of the rat: localization, morphology, connectivity and ultrastructure , 1995, Journal of neurocytology.

[15]  C. Hölscher,et al.  Quinolinic acid lesion of the rat entorhinal cortex pars medialis produces selective amnesia in allocentric working memory (WM), but not in egocentric WM , 1994, Behavioural Brain Research.

[16]  J. Coyle,et al.  Cholinergic innervation of mouse forebrain structures , 1994, The Journal of comparative neurology.

[17]  R. Insausti Comparative anatomy of the entorhinal cortex and hippocampus in mammals , 1993, Hippocampus.

[18]  R Jaffard,et al.  Role of the hippocampal formation in learning and memory , 1993, Hippocampus.

[19]  L. Jarrard On the role of the hippocampus in learning and memory in the rat. , 1993, Behavioral and neural biology.

[20]  D. Béracochéa,et al.  Extended temporal gradient for the retrograde and anterograde amnesia produced by ibotenate entorhinal cortex lesions in mice , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[21]  I. Ferrer,et al.  Parvalbumin and calbindin D-28K in the human entorhinal cortex. An immunohistochemical study , 1992, Brain Research.

[22]  L. Squire Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. , 1992, Psychological review.

[23]  J. J. Hagan,et al.  Behavioural and electrophysiological studies of entorhinal cortex lesions in the rat , 1992, Physiology & Behavior.

[24]  J. Rogers,et al.  Calretinin in rat brain: An immunohistochemical study , 1992, Neuroscience.

[25]  L. Slomianka,et al.  Distribution of acetylcholinesterase in the hippocampal region of the mouse: I. Entorhinal area, parasubiculum, retrosplenial area, and Presubiculum , 1991, The Journal of comparative neurology.

[26]  M. Celio,et al.  Calbindin D-28k and parvalbumin in the rat nervous system , 1990, Neuroscience.

[27]  D. Amaral,et al.  Topographical organization of the entorhinal projection to the dentate gyrus of the monkey , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[28]  D. Amaral,et al.  The entorhinal cortex of the monkey: I. Cytoarchitectonic organization , 1987, The Journal of comparative neurology.

[29]  F. Ebner,et al.  Development of cholinergic markers in mouse forebrain. I. Choline acetyltransferase enzyme activity and acetylcholinesterase histochemistry. , 1985, Brain research.

[30]  F. Ebner,et al.  Development of cholinergic markers in mouse forebrain. II. Muscarinic receptor binding in cortex. , 1985, Brain research.

[31]  G. Danscher,et al.  Entorhinal and prepiriform cortices of the European hedgehog. A hisstochemical and densitometric study based on a comparison between Timm's sulphide silver method and the selenium method , 1985, Brain Research.

[32]  C. Destrade,et al.  Late post-learning effect of entorhinal cortex electrical stimulation persists despite destruction of the perforant path , 1984, Brain Research.

[33]  M P Witter,et al.  Laminar origin and septotemporal distribution of entorhinal and perirhinal projections to the hippocampus in the cat , 1984, The Journal of comparative neurology.

[34]  C. Destrade,et al.  Functional dissociation between lateral and medial entorhinal cortex in memory processes in mice , 1983, Behavioural Brain Research.

[35]  C. Destrade,et al.  Late post-learning participation of entorhinal cortex in memory processes , 1982, Brain Research.

[36]  M. Gauthier,et al.  Behavioral effects of bilateral entorhinal cortex lesions in the Balb/c mouse. , 1981, Behavioral and neural biology.

[37]  J M Wyss,et al.  An autoradiographic study of the efferent connections of the entorhinal cortex in the rat , 1981, The Journal of comparative neurology.

[38]  Y. Arimatsu,et al.  An atlas of α‐bungarotoxin binding sites and structures containing acetylcholinesterase in the mouse central nervous system , 1981 .

[39]  M. Eckardt The Hippocampus as a Cognitive Map , 1980 .

[40]  A stereotaxic atlas of the albino mouse forebrain , 1979, Pharmacology Biochemistry and Behavior.

[41]  W. Cowan,et al.  An autoradiographic study of the organization of intrahippocampal association pathways in the rat , 1978, The Journal of comparative neurology.

[42]  W. Cowan,et al.  An autoradiographic study of the organization of the efferet connections of the hippocampal formation in the rat , 1977, The Journal of comparative neurology.

[43]  O. Steward,et al.  Cells of origin of entorhinal cortical afferents to the hippocampus and fascia dentata of the rat , 1976, The Journal of comparative neurology.

[44]  V. Caviness Architectonic map of neocortex of the normal mouse , 1975, The Journal of comparative neurology.

[45]  Deepak N. Pandya,et al.  Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections , 1975, Brain Research.

[46]  Deepak N. Pandya,et al.  Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. II. Frontal lobe afferents , 1975, Brain Research.

[47]  R. Sidman,et al.  Retrohippocampal, hippocampal and related structures of the forebrain in the reeler mutant mouse , 1973, The Journal of comparative neurology.

[48]  Walle J. H. Nauta,et al.  Connections of the Cerebral Cortex , 1964 .

[49]  T. Blackstad Commissural connections of the hippocampal region in the rat, with special reference to their mode of termination , 1956, The Journal of comparative neurology.

[50]  G B KOELLE,et al.  A Histochemical Method for Localizing Cholinesterase Activity.* , 1949, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[51]  W. Krieg Connections of the cerebral cortex. I. The albino rat. B. Structure of the cortical areas , 1946, The Journal of comparative neurology.

[52]  W. Krieg Connections of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas , 1946 .

[53]  L. Slomianka,et al.  Postnatal development of zinc‐containing cells and neuropil in the hippocampal region of the mouse , 1997, Hippocampus.

[54]  J. Hanke,et al.  Pigmentarchitectonic subfields of the entorhinal region as revealed in tangential sections. , 1997, Journal fur Hirnforschung.

[55]  D. Amaral,et al.  Perirhinal and postrhinal cortices of the rat: A review of the neuroanatomical literature and comparison with findings from the monkey brain , 1995, Hippocampus.

[56]  B T Hyman,et al.  Entorhinal cortex pathology in Alzheimer's disease , 1991, Hippocampus.

[57]  K. Brodmann Vergleichende Lokalisationslehre der Großhirnrinde : in ihren Prinzipien dargestellt auf Grund des Zellenbaues , 1985 .

[58]  W. Greenough,et al.  A stereotaxic atlas of the albino mouse forebrain. , 1980 .

[59]  H. Braak [Pigmentarchitecture of the human cortex cerebri. I. Regio entorhinalis]. , 1972, Zeitschrift fur Zellforschung und mikroskopische Anatomie.

[60]  A. Nappi,et al.  Alzheimer ' s Disease : Cell-Specific Pathology Isolates the Hippocampal Formation , 2022 .