Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo
暂无分享,去创建一个
[1] Paul D. Jones,et al. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation , 2009, British journal of pharmacology.
[2] R. Burghardt,et al. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase , 2009, Cell Biology and Toxicology.
[3] O. Fiehn,et al. Soluble Epoxide Hydrolase Inhibitors Reduce the Development of Atherosclerosis in Apolipoprotein E-Knockout Mouse Model , 2008, Journal of cardiovascular pharmacology.
[4] B. Humphreys,et al. The case / progressive hypertension and proteinuria on anti-angiogenic therapy. , 2008, Kidney international.
[5] J. Gerss,et al. Prospective Comparison of Sorafenib and Sunitinib for Second-Line Treatment of Cytokine-Refractory Kidney Cancer Patients , 2008, Oncology.
[6] H. Mukai,et al. Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors , 2008, Cancer science.
[7] P. Brossart,et al. Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. , 2008, Blood.
[8] J. Patard,et al. Toxicities associated with the administration of sorafenib, sunitinib, and temsirolimus and their management in patients with metastatic renal cell carcinoma. , 2008, European urology.
[9] E. Raymond,et al. New developments in multitargeted therapy for patients with solid tumours. , 2008, Cancer treatment reviews.
[10] J. Kolesar,et al. Role of sunitinib and sorafenib in the treatment of metastatic renal cell carcinoma. , 2008, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
[11] W. Stock,et al. Anti-Angiogenic Effects of Sorafenib in Relapsed Chronic Lymphocytic Leukemia: Correlative Studies of a Phase 2 Clinical Trial. , 2007 .
[12] Kenneth P. Roos,et al. Autocrine VEGF Signaling Is Required for Vascular Homeostasis , 2007, Cell.
[13] S. Hwang,et al. Orally bioavailable potent soluble epoxide hydrolase inhibitors. , 2007, Journal of medicinal chemistry.
[14] J. P. Bowen,et al. Molecular design and clinical development of VEGFR kinase inhibitors. , 2007, Current topics in medicinal chemistry.
[15] Jeffrey W. Clark,et al. Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumors. , 2007, The oncologist.
[16] G. Gross,et al. Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury. , 2007, Prostaglandins & other lipid mediators.
[17] M. Sılay,et al. Sunitinib malate and sorafenib may be beneficial at the treatment of advanced bladder cancer due to their anti-angiogenic effects. , 2007, Medical hypotheses.
[18] S. Wilhelm,et al. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models , 2007, Cancer Chemotherapy and Pharmacology.
[19] B. Hammock,et al. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors , 2006, Proceedings of the National Academy of Sciences.
[20] A. El-Kadi,et al. Cytochrome P450 enzymes: central players in cardiovascular health and disease. , 2006, Pharmacology & therapeutics.
[21] Paul D. Jones,et al. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. , 2006, Bioorganic & medicinal chemistry letters.
[22] B. Hammock,et al. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors , 2006, Proceedings of the National Academy of Sciences.
[23] B. Rini,et al. Anti-proliferative effects of sorafenib in clear cell renal cell carcinoma (CCRCC) cell lines: Relationship to von Hippel Lindau protein (pVHL) expression and hypoxia. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[24] E. Friedman,et al. Multipopulation analysis of polymorphisms in five mononucleotide repeats used to determine the microsatellite instability status of human tumors. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] Pei-yin Lin,et al. Kidney cancer: identification of novel targets for therapy. , 2006, Kidney international.
[26] D. Christianson,et al. Human soluble epoxide hydrolase: Structural basis of inhibition by 4‐(3‐cyclohexylureido)‐carboxylic acids , 2006, Protein science : a publication of the Protein Society.
[27] B. Hammock,et al. An Orally Active Epoxide Hydrolase Inhibitor Lowers Blood Pressure and Provides Renal Protection in Salt-Sensitive Hypertension , 2005, Hypertension.
[28] J. Imig. Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases. , 2005, American journal of physiology. Renal physiology.
[29] Paul D. Jones,et al. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. , 2005, Analytical biochemistry.
[30] R. Hui,et al. Arachidonic Acid Epoxygenase Metabolites Stimulate Endothelial Cell Growth and Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways , 2005, Journal of Pharmacology and Experimental Therapeutics.
[31] A. Pozzi,et al. Characterization of 5,6- and 8,9-Epoxyeicosatrienoic Acids (5,6- and 8,9-EET) as Potent in Vivo Angiogenic Lipids* , 2005, Journal of Biological Chemistry.
[32] B. Hammock,et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[33] R. Busse,et al. Soluble Epoxide Hydrolase Is a Main Effector of Angiotensin II–Induced Hypertension , 2005, Hypertension.
[34] S. Doggrell. Cytochrome P-450: a new target in the heart and coronary circulation , 2005 .
[35] B. Hammock,et al. Epoxide hydrolases: their roles and interactions with lipid metabolism. , 2005, Progress in lipid research.
[36] R. Roman,et al. Role of cytochrome P450 metabolites of arachidonic acid in hypertension. , 2004, Current drug metabolism.
[37] Bruce D Hammock,et al. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. , 2004, Biochemistry.
[38] D. Barford,et al. Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF , 2004, Cell.
[39] J. Pollard. Tumour-educated macrophages promote tumour progression and metastasis , 2004, Nature Reviews Cancer.
[40] J. Falck,et al. 5,6-Epoxyeicosatrienoic Acid Mediates the Enhanced Renal Vasodilation to Arachidonic Acid in the SHR , 2003, Hypertension.
[41] Nathan R. McElroy,et al. QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds. , 2003, Journal of medicinal chemistry.
[42] C. Wheelock,et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. , 2002, Biochemical pharmacology.
[43] B. Hammock,et al. Soluble Epoxide Hydrolase Inhibition Lowers Arterial Blood Pressure in Angiotensin II Hypertension , 2002, Hypertension.
[44] Alberto Mantovani,et al. Inflammation and cancer: back to Virchow? , 2001, The Lancet.
[45] B D Hammock,et al. Binding of Alkylurea Inhibitors to Epoxide Hydrolase Implicates Active Site Tyrosines in Substrate Activation* , 2000, The Journal of Biological Chemistry.
[46] W. Campbell. New role for epoxyeicosatrienoic acids as anti-inflammatory mediators. , 2000, Trends in pharmacological sciences.
[47] K. Ley,et al. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. , 1999, Science.
[48] B D Hammock,et al. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[49] B. Borhan,et al. Improved radiolabeled substrates for soluble epoxide hydrolase. , 1995, Analytical biochemistry.
[50] B. Hammock,et al. cDNA cloning and expression of a soluble epoxide hydrolase from human liver. , 1993, Archives of biochemistry and biophysics.
[51] B D Hammock,et al. Affinity purification of cytosolic epoxide hydrolase using derivatized epoxy-activated Sepharose gels. , 1988, Analytical biochemistry.
[52] J. Falck,et al. Vasoactivity of arachidonic acid epoxides. , 1987, European journal of pharmacology.
[53] M. Dixon. The graphical determination of Km and Ki , 1972 .