论文信息 - Response: T cells are required for the CMV-induced antileukemia effect after transplant

Response: T cells are required for the CMV-induced antileukemia effect after transplant

With great interest we read the letter by Thomson and coworkers who reported the results of their retrospective study evaluating the antileukemic effect of a CMV-replication after T cell–depleted transplantation using Campath in 100 patients with AML[1][1]. Further, they evaluated the effect of a

[1] S. Mackinnon,et al. CMV-specific cellular therapy for acute myeloid leukemia? , 2012, Blood.

[2] S. Schnittger,et al. Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients. , 2011, Blood.

[3] C. Craddock,et al. Factors predicting outcome after unrelated donor stem cell transplantation in primary refractory acute myeloid leukaemia , 2011, Leukemia.

[4] P. Moss,et al. Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines , 2003, The Lancet.

[5] A. Elmaagacli,et al. Outcome of transplantation of highly purified peripheral blood CD34+ cells with T-cell add-back compared with unmanipulated bone marrow or peripheral blood stem cells from HLA-identical sibling donors in patients with first chronic phase chronic myeloid leukemia. , 2003, Blood.