Pediatric Corneal Transplants: Review of Current Practice Patterns

Purpose: To facilitate development of standardized guidelines for management of pediatric patients undergoing keratoplasty, particularly the youngest cohort, through a comprehensive survey assessing recent trends in practice patterns of corneal specialists and pediatric ophthalmologists. Methods: A cross-sectional, observational study of current practices pertaining to pediatric keratoplasty was performed by designing a 20-question survey focused on preoperative indications, surgical techniques, and postoperative management. This survey was sent electronically to corneal specialists and pediatric ophthalmologists. Results were compared with the findings of previous studies regarding pediatric keratoplasty. Results: Of the 80 ophthalmologists who responded, 51.3% currently perform pediatric keratoplasty; only 20% have performed >50 cases. The majority (73.8%) completed solely corneal fellowships; all perform penetrating keratoplasty, 35.2% also perform endothelial keratoplasty, and 37% also perform lamellar keratoplasty. Peters anomaly was the most common indication for transplantation (34.3%). The majority believe that 1 to 3 months is the optimal age range to perform keratoplasty for both monocular and binocular congenital corneal opacities, although 13% stated that they would never perform keratoplasty in a patient with a monocular opacity. All surgeons report modifying their intraoperative techniques for pediatric patients, but specific practices and postoperative management protocols vary. There is a consensus regarding the importance of amblyopia therapy in these patients. Conclusions: Our results were consistent with the published literature regarding the indication and types of surgery performed. Variability among surgical techniques and postoperative management protocols highlights the necessity of creating standardized guidelines to optimize management of pediatric patients undergoing keratoplasty. Collaborative efforts between corneal and pediatric specialists are crucial for defining visual rehabilitation protocols to enhance visual outcomes.

[1]  E. Hernández-Quintela,et al.  Indications and outcomes of pediatric keratoplasty in a tertiary eye care center , 2017, Medicine.

[2]  C. Rapuano,et al.  Pediatric corneal transplants , 2017, Current opinion in ophthalmology.

[3]  S. Bonini,et al.  The challenging management of pediatric corneal transplantation: an overview of surgical and clinical experiences , 2017, Japanese Journal of Ophthalmology.

[4]  C. Rapuano,et al.  Survival of Primary Penetrating Keratoplasty in Children. , 2016, American journal of ophthalmology.

[5]  J. Aquavella Incidence of peters anomaly and congenital opacity. , 2015, Cornea.

[6]  D. Tan,et al.  The outcomes of primary pediatric keratoplasty in Singapore. , 2014, American journal of ophthalmology.

[7]  H. Anwar,et al.  Endothelial keratoplasty in children , 2014, Current opinion in ophthalmology.

[8]  L. Speedwell,et al.  Defining Success in Infant Penetrating Keratoplasty for Developmental Corneal Opacities , 2014, The American orthoptic journal.

[9]  K. Nischal,et al.  Paediatric keratoplasty: choices and conundrums , 2013, British Journal of Ophthalmology.

[10]  M. Mannis,et al.  Pediatric Penetrating Keratoplasty , 2013, International ophthalmology clinics.

[11]  K. Nischal A new approach to the classification of neonatal corneal opacities , 2012, Current opinion in ophthalmology.

[12]  D. Coster,et al.  The outcome of corneal transplantation in infants, children, and adolescents. , 2011, Ophthalmology.

[13]  L. el Matri,et al.  Pediatric penetrating keratoplasty: indications and outcomes. , 2011, Transplantation proceedings.

[14]  M. Mannis,et al.  Primary Pediatric Keratoplasty: Indications and Outcomes , 2009, Cornea.

[15]  T. Dada,et al.  Pediatric keratoplasty. , 2009, Survey of ophthalmology.

[16]  K. Colby,et al.  Update on Pediatric Keratoplasty , 2008, International ophthalmology clinics.

[17]  R. Tandon,et al.  Pediatric Keratoplasty in India: Indications and Outcomes , 2007, Cornea.

[18]  M. Wagoner,et al.  Primary pediatric keratoplasty: indications, graft survival, and visual outcome. , 2007, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus.

[19]  J. Sugar,et al.  The indications for and outcome in pediatric keratoplasty. A multicenter study. , 1995, Ophthalmology.