TAFs mediate transcriptional activation and promoter selectivity.

The TATA-binding protein (TBP)-associated factors (TAFs) of TFIID play a central role in RNA polymerase II transcriptional regulation. Some TAFs can function as co-activators that mediate the activation signal from enhancer-bound regulators. In addition, interactions between selected TAFs and core elements direct promoter selectivity by RNA polymerase II.

[1]  R. Tjian,et al.  Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II , 1995, Cell.

[2]  X. Jacq,et al.  Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor , 1994, Cell.

[3]  D. Gilmour,et al.  Protein/DNA crosslinking of a TFIID complex reveals novel interactions downstream of the transcription start. , 1994, Nucleic acids research.

[4]  Winship Herr,et al.  Basal promoter elements as a selective determinant of transcriptional activator function , 1995, Nature.

[5]  H. Xiao,et al.  Recruiting TATA-binding protein to a promoter: transcriptional activation without an upstream activator , 1995, Molecular and cellular biology.

[6]  R. Roeder,et al.  Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators , 1995, Science.

[7]  R. Roeder,et al.  Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region , 1985, Cell.

[8]  Robert Tjian,et al.  Mechanism of transcriptional activation by Sp1: Evidence for coactivators , 1990, Cell.

[9]  R. Tjian,et al.  p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. , 1995, Science.

[10]  C. Verrijzer,et al.  CIF, an essential cofactor for TFIID-dependent initiator function. , 1996, Genes & development.

[11]  A. Rougvie,et al.  The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged , 1988, Cell.

[12]  R. Tjian,et al.  TAFs and TFIIA mediate differential utilization of the tandem Adh promoters , 1995, Cell.

[13]  W. Mercer,et al.  Expression of thymidine kinase and dihydrofolate reductase genes in mammalian ts mutants of the cell cycle. , 1985, The Journal of biological chemistry.

[14]  W. Herr,et al.  Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter , 1992, Cell.

[15]  Pamela Reinagel,et al.  Contact with a component of the polymerase II holoenzyme suffices for gene activation , 1995, Cell.

[16]  T. Burke,et al.  Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. , 1996, Genes & development.

[17]  K. Struhl,et al.  Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain , 1995, Nature.

[18]  Paul Lieberman,et al.  A general mechanism for transcriptional synergy by eukaryotic activators , 1995, Nature.

[19]  Robert Tjian,et al.  Multiple TAFIIs Directing Synergistic Activation of Transcription , 1995, Science.

[20]  K. Struhl,et al.  Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo. , 1994, Science.

[21]  M. Strubin,et al.  Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo , 1995, Nature.

[22]  R. Roeder,et al.  TATA‐binding protein‐associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA‐less class II promoter. , 1994, The EMBO journal.

[23]  M. Horikoshi,et al.  Mechanism of action of a yeast activator: Direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions , 1988, Cell.

[24]  D. Reinberg,et al.  Common themes in assembly and function of eukaryotic transcription complexes. , 1995, Annual review of biochemistry.

[25]  Y. Nakamura,et al.  The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein , 1991, Molecular and cellular biology.

[26]  R. Tjian,et al.  Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators , 1994, Cell.

[27]  R. Tjian,et al.  TAFII250 Is a Bipartite Protein Kinase That Phosphorylates the Basal Transcription Factor RAP74 , 1996, Cell.

[28]  P. Sharp,et al.  Five intermediate complexes in transcription initiation by RNA polymerase II , 1989, Cell.

[29]  R. Tjian,et al.  Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation , 1991, Cell.

[30]  A. Hoffmann,et al.  Unique TATA‐binding protein‐containing complexes and cofactors involved in transcription by RNA polymerases II and III. , 1993, The EMBO journal.

[31]  R. Tjian,et al.  Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA. , 1994, Science.

[32]  Michael R. Green,et al.  Eukaryotic activators function during multiple steps of preinitiation complex assembly , 1993, Nature.

[33]  R. Tjian,et al.  Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250. , 1994, Science.

[34]  S. Smale,et al.  Core promoter specificities of the Sp1 and VP16 transcriptional activation domains , 1995, Molecular and cellular biology.

[35]  R. Tjian,et al.  DNA Template and Activator-Coactivator Requirements for Transcriptional Synergism by Drosophila Bicoid , 1995, Science.

[36]  Yang Li,et al.  A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II , 1994, Cell.

[37]  Michael R. Green,et al.  Yeast TAF IIS in a multisubunit complex required for activated transcription , 1994, Nature.