An exclusion map of Marfan syndrome.

The combined genetic data between the Marfan syndrome and 75 informative loci on 18 autosomes were used to construct an exclusion map for this disorder. Data are also presented for a further two unmapped markers. The most likely location of the Marfan syndrome gene is highlighted and all the unexcluded areas of the genome are displayed in a graphical form. This exclusion map shows that almost 75% of the genome has been excluded as a likely location for the Marfan syndrome gene in the majority of the families studied. Apart from chromosomes 8, 13, 21, and 22, for which no data were available, other regions not excluded yet include 5p, 6p, 9p, 10p, 12p, 15, 17p, 18, and 20p. Future linkage analysis using markers located in the highlighted regions should facilitate the identification of the site of the Marfan syndrome gene.

[1]  C. Junien,et al.  Linkage analysis of five fibrillar collagen loci in a large French Marfan syndrome family. , 1990, Journal of medical genetics.

[2]  A. Child,et al.  Linkage data for Marfan syndrome and markers on chromosomes 1 and 11. , 1990, Journal of medical genetics.

[3]  S. Blanton,et al.  Linkage analysis in Marfan syndrome. , 1990, Journal of medical genetics.

[4]  D. Meyers,et al.  Marfan syndrome: exclusion of genetic linkage to three major collagen genes. , 1988, American journal of medical genetics.

[5]  R. Dalgleish,et al.  Segregation of all four major fibrillar collagen genes in the Marfan syndrome. , 1987, American journal of human genetics.

[6]  J. Edwards,et al.  An exclusion map for Von Recklinghausen neurofibromatosis. , 1987, Journal of medical genetics.

[7]  J. Edwards.  Exclusion mapping. , 1987, Journal of medical genetics.

[8]  R. Dalgleish,et al.  Exclusion of the alpha 2(I) and alpha 1(III) collagen genes as the mutant loci in a Marfan syndrome family. , 1987, Journal of medical genetics.

[9]  P. Harper,et al.  Marfan syndrome: exclusion of genetic linkage to the COL1A2 gene. , 1986, Clinical genetics.

[10]  M. Mace.  A suggestion of linkage between the Marfan syndrome and the rhesus blood group , 1979, Clinical genetics.

[11]  V. McKusick,et al.  The Marfan syndrome: diagnosis and management. , 1979, The New England journal of medicine.

[12]  V. McKusick,et al.  A linkage study of the Marfan syndrome 1 , 1976, Clinical genetics.

[13]  R. Dalgleish,et al.  Exclusion of the u2(I) and ul(III) collagen genes as the mutant loci in a Marfan syndrome family , 2022 .