Calcium deficiency worldwide: prevalence of inadequate intakes and associated health outcomes

Dietary calcium deficiency is considered to be widespread globally, with published estimates suggesting that approximately half of the world's population has inadequate access to dietary calcium. Calcium is essential for bone health, but inadequate intakes have also been linked to other health outcomes, including pregnancy complications, cancers, and cardiovascular disease. Populations in low‐ and middle‐income countries (LMICs) are at greatest risk of low calcium intakes, although many individuals in high‐income countries (HICs) also do not meet recommendations. Paradoxically, many LMICs with lower calcium intakes show lower rates of osteoporotic fracture as compared with HICs, though data are sparse. Calcium intake recommendations vary across agencies and may need to be customized based on other dietary factors, health‐related behaviors, or the risk of calcium‐related health outcomes. The lack of standard methods to assess the calcium status of an individual or population has challenged efforts to estimate the prevalence of calcium deficiency and the global burden of related adverse health consequences. This paper aims to consolidate available evidence related to the global prevalence of inadequate calcium intakes and associated health outcomes, with the goal of providing a foundation for developing policies and population‐level interventions to safely improve calcium intake and status where necessary.

[1]  K. Kraemer,et al.  Interventions to improve calcium intake through foods in populations with low intake , 2022, Annals of the New York Academy of Sciences.

[2]  W. Fawzi,et al.  Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations , 2021, Annals of the New York Academy of Sciences.

[3]  P. Ashorn,et al.  Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis , 2021, Annals of the New York Academy of Sciences.

[4]  S. Abe,et al.  Polymorphisms Contributing to Calcium Status: A Systematic Review , 2021, Nutrients.

[5]  S. Mukhopadhyay,et al.  The Indian Society for Bone and Mineral Research (ISBMR) position statement for the diagnosis and treatment of osteoporosis in adults , 2021, Archives of Osteoporosis.

[6]  C. Harinarayan,et al.  Modern India and Dietary Calcium Deficiency—Half a Century Nutrition Data—Retrospect–Introspect and the Road Ahead , 2021, Frontiers in Endocrinology.

[7]  C. Sempos,et al.  Serum 25-hydroxyvitamin D requirements to prevent nutritional rickets in Nigerian children on a low-calcium diet-a multivariable reanalysis. , 2021, The American journal of clinical nutrition.

[8]  J. Kanis,et al.  FRAX-based fracture probabilities in South Africa , 2021, Archives of Osteoporosis.

[9]  L. Jafri,et al.  Clinical characteristics and outcomes of patients presenting with hip fractures at a tertiary care hospital in Pakistan , 2021, Archives of Osteoporosis.

[10]  J. Kanis,et al.  Epidemiology of hip fracture in Botswana , 2021, Archives of Osteoporosis.

[11]  B. Cassim,et al.  Prevalence and clinical risk factors for morphometric vertebral fractures in older subjects in KwaZulu-Natal , 2021 .

[12]  N. Kiwanuka,et al.  Bone Mineral Density in Antiretroviral Therapy‐Naïve HIV‐1–Infected Young Adult ‐Women Using Depot Medroxyprogesterone Acetate or Nonhormonal Contraceptives in Uganda , 2020, JBMR plus.

[13]  B. Poindexter,et al.  Nutritional Care of Preterm Infants , 2021, World Review of Nutrition and Dietetics.

[14]  J. P. Peña-Rosas,et al.  Current calcium fortification experiences: a review , 2020, Annals of the New York Academy of Sciences.

[15]  P. Polidori,et al.  Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis , 2020, Nutrients.

[16]  S. Yeap,et al.  Osteoporosis in South-East Asian Countries. , 2020, The Clinical biochemist. Reviews.

[17]  D. Roy,et al.  A comparison of the Indian diet with the EAT-Lancet reference diet , 2020, BMC Public Health.

[18]  Satyajit Bagudai,et al.  Prevalence of Osteoporosis and Osteopenia Status among Nepalese Population using Calcaneal Ultrasonography Method , 2019 .

[19]  S. Lekamwasam,et al.  Trabecular bone score and bone mineral density reference data for women aged 20–70 years and the effect of local reference data on the prevalence of postmenopausal osteoporosis: a cross-sectional study from Sri Lanka , 2019, Archives of Osteoporosis.

[20]  J. Belizán,et al.  Calcium Intake and Health , 2019, Nutrients.

[21]  S. Sultana,et al.  Using a gender lens to understand eating behaviours of adolescent females living in low‐income households in Bangladesh , 2019, Maternal & child nutrition.

[22]  P. Pradhan,et al.  Association of Lifestyle and Food Consumption with Bone Mineral Density among People Aged 50 Years and Above Attending the Hospitals of Kathmandu, Nepal , 2019, Journal of osteoporosis.

[23]  J. Belizán,et al.  Mechanisms Involved in the Relationship between Low Calcium Intake and High Blood Pressure , 2019, Nutrients.

[24]  J. S. San Martin,et al.  Rickets severity predicts clinical outcomes in children with X-linked hypophosphatemia: Utility of the radiographic Rickets Severity Score. , 2019, Bone.

[25]  A. Ciapponi,et al.  Global inequities in dietary calcium intake during pregnancy: a systematic review and meta‐analysis , 2018, BJOG : an international journal of obstetrics and gynaecology.

[26]  T. Wallace Optimizing Dietary Protein for Lifelong Bone Health , 2019, Nutrition Today.

[27]  R. Markwald,et al.  Chapter 1 Introduction to COVID-19 , 2022, COVID-19 in the Environment.

[28]  R. Stoltzfus,et al.  With adaptation, the WHO guidelines on calcium supplementation for prevention of pre‐eclampsia are adopted by pregnant women , 2018, Maternal & child nutrition.

[29]  L. Jafri,et al.  Osteoporosis and its perspective in Pakistan: A review of evidence and issues for addressing fragility fractures , 2018, Annals of medicine and surgery.

[30]  C. Cheung,et al.  An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study , 2018, Osteoporosis and sarcopenia.

[31]  Michel Lelo Tshikwela,et al.  Morphometric semi-quantitative assessment of vertebral fractures in postmenopausal black women in Central Africa , 2018, Archives of Osteoporosis.

[32]  G. Matthews,et al.  Osteoporotic hip fractures in Black South Africans: a regional study , 2017, Archives of Osteoporosis.

[33]  R. Rizzoli,et al.  Global dietary calcium intake among adults: a systematic review , 2017, Osteoporosis International.

[34]  Changwei Li,et al.  The Effects of Dietary Calcium Supplements Alone or With Vitamin D on Cholesterol Metabolism: A Meta-Analysis of Randomized Controlled Trials , 2017, The Journal of cardiovascular nursing.

[35]  E. Aurino Do boys eat better than girls in India? Longitudinal evidence on dietary diversity and food consumption disparities among children and adolescents , 2017, Economics and human biology.

[36]  J. Pettifor,et al.  Nutritional rickets around the world: an update , 2017, Paediatrics and international child health.

[37]  M. Budoff,et al.  Calcium Intake From Diet and Supplements and the Risk of Coronary Artery Calcification and its Progression Among Older Adults: 10‐Year Follow‐up of the Multi‐Ethnic Study of Atherosclerosis (MESA) , 2016, Journal of the American Heart Association.

[38]  A. Zengin,et al.  Ethnic differences in bone geometry between White, Black and South Asian men in the UK☆ , 2016, Bone.

[39]  N. Al-Sadat,et al.  Vitamin D and Calcium Intakes, Physical Activity, and Calcaneus BMC among School-Going 13-Year Old Malaysian Adolescents , 2016, Nutrients.

[40]  K. Uenishi,et al.  Recent nutritional trends of calcium and vitamin D in East Asia , 2016, Osteoporosis and sarcopenia.

[41]  S. Bonovas,et al.  Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials. , 2016, World journal of gastroenterology.

[42]  F. Ghani,et al.  Bone Turnover Markers for Osteoporosis Status Assessment at Baseline in Postmenopausal Pakistani Females. , 2016, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[43]  A. Khadilkar,et al.  International Journal of Women's Health Dovepress Epidemiology and Treatment of Osteoporosis in Women: an Indian Perspective , 2022 .

[44]  J. Shepherd,et al.  US White and Black Women Do Not Represent the Bone Mineral Density of Sub-Saharan Black Women. , 2015, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[45]  I. Reid,et al.  Calcium intake and bone mineral density: systematic review and meta-analysis , 2015, BMJ : British Medical Journal.

[46]  I. Reid,et al.  Calcium intake and risk of fracture: systematic review , 2015, BMJ : British Medical Journal.

[47]  A. Ciapponi,et al.  Calcium supplementation for prevention of primary hypertension. , 2015, The Cochrane database of systematic reviews.

[48]  E. Joy,et al.  Dietary calcium and zinc deficiency risks are decreasing but remain prevalent , 2015, Scientific Reports.

[49]  D. Akerele Household Food Expenditure Patterns, Food Nutrient Consumption and Nutritional Vulnerability in Nigeria: Implications for Policy , 2015, Ecology of food and nutrition.

[50]  Efsa Panel on Dietetic Products Scientific opinion on Dietary Reference Values for calcium. , 2015 .

[51]  James Y. Dai,et al.  Factors associated with bone mineral density in healthy African women , 2015, Archives of Osteoporosis.

[52]  A. Scher,et al.  Vertebral fracture prevalence in black and white South African women , 2015, Archives of Osteoporosis.

[53]  N. Thomas,et al.  Osteoporosis in Healthy South Indian Males and the Influence of Life Style Factors and Vitamin D Status on Bone Mineral Density , 2014, Journal of osteoporosis.

[54]  J. Pettifor Calcium and Vitamin D Metabolism in Children in Developing Countries , 2014, Annals of Nutrition and Metabolism.

[55]  A. Mithal,et al.  The Asia-Pacific Regional Audit-Epidemiology, Costs, and Burden of Osteoporosis in India 2013: A report of International Osteoporosis Foundation , 2014, Indian journal of endocrinology and metabolism.

[56]  R. Iqbal,et al.  Validation of a food frequency questionnaire for assessing macronutrient and calcium intake in adult Pakistani population. , 2014, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[57]  Mahbubur Rahman,et al.  Osteopenia and Osteoporosis Among 16–65 Year Old Women Attending Outpatient Clinics , 2014, Journal of Community Health.

[58]  H. Vorster,et al.  1. An introduction to the revised food-based dietary guidelines for South Africa , 2013 .

[59]  V. Moyer Vitamin D and Calcium Supplementation to Prevent Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement , 2013, Annals of Internal Medicine.

[60]  C. Cooper,et al.  Incidence of hip fracture in Rohtak district, North India , 2013, Archives of Osteoporosis.

[61]  K. Yeum,et al.  Impact of calcium and vitamin D insufficiencies on serum parathyroid hormone and bone mineral density: Analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV‐3, 2009 and KNHANES V‐1, 2010) , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[62]  A. Verma,et al.  Cross sectional study of osteoporosis among women. , 2013, Medical journal, Armed Forces India.

[63]  V. Moyer Screening for Intimate Partner Violence and Abuse of Elderly and Vulnerable Adults: U.S. Preventive Services Task Force Recommendation Statement , 2013, Annals of Internal Medicine.

[64]  N. Agrawal,et al.  Prevalence of osteoporosis in otherwise healthy Indian males aged 50 years and above , 2013, Archives of Osteoporosis.

[65]  M. Akhtaruzzaman,et al.  Nutrition, Health and Demographic Survey of Bangladesh-2011 , 2013 .

[66]  J. Manson,et al.  Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study , 2012, Osteoporosis International.

[67]  Jose Jackson-Malete,et al.  Validation and reproducibility of an FFQ for use among adults in Botswana , 2012, Public Health Nutrition.

[68]  N. Tandon,et al.  The prevalence of and risk factors for radiographic vertebral fractures in older Indian women and men: Delhi Vertebral Osteoporosis Study (DeVOS) , 2012, Archives of Osteoporosis.

[69]  C. Lassale,et al.  Protein intake, calcium balance and health consequences , 2012, European Journal of Clinical Nutrition.

[70]  S. Chiplonkar,et al.  Bone Status of Women Over 40 Years of Age from Two Socioeconomic Strata , 2012, Endocrine research.

[71]  S. Mitra,et al.  Dietary Calcium Intake, Vitamin D Status, and Bone Health in Postmenopausal Women in Rural Pakistan , 2011, Journal of health, population, and nutrition.

[72]  J. Muyonga,et al.  Nutrient-enhancement of matooke banana for improved nutrient intake of people living with HIV/AIDS in Rakai district, Uganda. , 2011 .

[73]  J. Thakur,et al.  Prevalence and related risk factors of osteoporosis in peri- and postmenopausal Indian women , 2011, Journal of mid-life health.

[74]  JoAnn E. Manson,et al.  The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know , 2010, The Journal of clinical endocrinology and metabolism.

[75]  N. Tandon,et al.  Bone health in healthy Indian population aged 50 years and above , 2011, Osteoporosis International.

[76]  S. Chiplonkar,et al.  Low bone mass in urban Indian women above 40 years of age: prevalence and risk factors , 2010, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[77]  A. Wickremasinghe,et al.  Prevalence and predictors of osteoporosis in an urban Sri Lankan population , 2010, International journal of rheumatic diseases.

[78]  J. Unni,et al.  Bone mineral density in women above 40 years , 2010, Journal of mid-life health.

[79]  S. Lekamwasam,et al.  Prevalence and determinants of osteoporosis among men aged 50 years or more in Sri Lanka: a community-based cross-sectional study , 2009, Archives of osteoporosis.

[80]  T. Trikalinos,et al.  Vitamin D and calcium: a systematic review of health outcomes. , 2009, Evidence report/technology assessment.

[81]  F. Mansuri,et al.  Association of menopause with osteopenia and osteoporosis: results from population based study done in Karachi. , 2009, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[82]  A. Babu,et al.  Osteoporosis and osteopenia in India: a few more observations. , 2009, Indian journal of medical sciences.

[83]  A. Afghan,et al.  Determining the risk factors and prevalence of osteoporosis using quantitative ultrasonography in Pakistani adult women. , 2009, Singapore medical journal.

[84]  N. Thomas,et al.  Prevalence of osteoporosis in ambulatory postmenopausal women from a semiurban region in Southern India: relationship to calcium nutrition and vitamin D status. , 2008, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[85]  G. Curhan,et al.  Determinants of 24-hour urinary oxalate excretion. , 2008, Clinical journal of the American Society of Nephrology : CJASN.

[86]  J. Aloia African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox. , 2008, The American journal of clinical nutrition.

[87]  N. Steyn,et al.  National fortification of staple foods can make a significant contribution to micronutrient intake of South African adults , 2008, Public Health Nutrition.

[88]  A. Mithal,et al.  The assessment of osteoporosis risk factors in Iranian women compared with Indian women , 2008, BMC musculoskeletal disorders.

[89]  C. Barba,et al.  Recommended dietary allowances harmonization in Southeast Asia. , 2008, Asia Pacific journal of clinical nutrition.

[90]  S. Lanham-New,et al.  Calcium supplementation and weight bearing physical activity--do they have a combined effect on the bone density of pre-pubertal children? , 2007, Bone.

[91]  S. Lekamwasam,et al.  Prevalence of osteoporosis among postmenopausal women in Sri Lanka: a cross‐sectional community study , 2007 .

[92]  David Moher,et al.  Effectiveness and safety of vitamin D in relation to bone health. , 2007, Evidence report/technology assessment.

[93]  George P McCabe,et al.  Racial differences in skeletal calcium retention in adolescent girls with varied controlled calcium intakes. , 2007, The American journal of clinical nutrition.

[94]  T. Winzenberg,et al.  Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials , 2006, BMJ : British Medical Journal.

[95]  M. Zeegers,et al.  Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials , 2006, Journal of Human Hypertension.

[96]  A. Prentice,et al.  Case-control study of breast milk calcium in mothers of children with and without nutritional rickets. , 2006, Acta paediatrica.

[97]  V. Tandon,et al.  Preliminary screening of osteoporosis and osteopenia in urban women from Jammu using calcaneal QUS. , 2006, Indian journal of medical sciences.

[98]  F. Beyer,et al.  Calcium supplementation for the management of primary hypertension in adults. , 2006, The Cochrane database of systematic reviews.

[99]  G. Sigurdsson,et al.  Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. , 2005, JAMA.

[100]  N. Balakrishna,et al.  Bone status of Indian women from a low-income group and its relationship to the nutritional status , 2005, Osteoporosis International.

[101]  Codex Alimentarius Commission,et al.  WORLD HEALTH ORGANIZATION FOOD AND AGRICULTURAL ORGANIZATION OF THE UNITED NATIONS , 2007 .

[102]  R. Swaminathan,et al.  Effect of acute oral calcium load on serum PTH and bone resorption in young healthy subjects: an overnight study , 2004, European Journal of Clinical Nutrition.

[103]  S. Lekamwasam,et al.  Osteoporosis in Sri Lanka. , 2004, Clinical calcium.

[104]  D. A. Barondess,et al.  Comparison of Cross‐Sectional Geometry of the Proximal Femur in White and Black Women from Detroit and Johannesburg , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[105]  M. Mercado,et al.  Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran". , 2003, Archives of surgery.

[106]  T. Binkley,et al.  Randomized Trial of Physical Activity and Calcium Supplementation on Bone Mineral Content in 3‐ to 5‐Year‐Old Children , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[107]  N. Bishop,et al.  Rickets , 1906, The Lancet.

[108]  W. O'Fallon,et al.  Variations in Bone Density among Persons of African Heritage , 2002, Osteoporosis International.

[109]  J. Belizán,et al.  A deficient maternal calcium intake during pregnancy increases blood pressure of the offspring in adult rats , 2002, BJOG : an international journal of obstetrics and gynaecology.

[110]  Susan R. Johnson,et al.  Osteoporosis prevention, diagnosis, and therapy. , 2001, JAMA.

[111]  J. Kerstetter,et al.  Nutrition in Bone Health Revisited: A Story Beyond Calcium , 2000, Journal of the American College of Nutrition.

[112]  G. Chan,et al.  Case-control study of factors associated with nutritional rickets in Nigerian children. , 2000, The Journal of pediatrics.

[113]  S. Cummings,et al.  Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences. , 1997, The Journal of clinical endocrinology and metabolism.

[114]  T J Cole,et al.  Low bone mineral content is common but osteoporotic fractures are rare in elderly rural Gambian women , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[115]  L. Melton,et al.  The worldwide problem of osteoporosis: insights afforded by epidemiology. , 1995, Bone.

[116]  J. Pettifor,et al.  Ethnic differences in bone density in female South African nurses , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[117]  M. Wiseman The COMA Report: Dietary Reference Values for Food Energy and Nutrients for the United Kingdom , 1992 .

[118]  C. Cooper,et al.  Fractures of the hip and distal forearm in West Africa and the United Kingdom. , 1991, Age and ageing.

[119]  G. Rinaldi,et al.  Dietary Calcium and Cell Membrane Abnormality in Genetic Hypertension , 1989, Hypertension.

[120]  J. L. Larraurí Comer bien para vivir mejor , 1988 .

[121]  B. Pence,et al.  Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3. , 1988, Carcinogenesis.

[122]  W. R. Bruce,et al.  Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. , 1984, Journal of the National Cancer Institute.

[123]  C. Dent,et al.  Osteoporosis of Lumbar Vertebrae and Calcification of Abdominal Aorta in Women Living in Durban , 1968, British medical journal.

[124]  L. Solomon Osteoporosis and fracture of the femoral neck in the South African Bantu. , 1968, The Journal of bone and joint surgery. British volume.