X-ray grating interferometer for biomedical imaging applications at Shanghai Synchrotron Radiation Facility.

An X-ray grating interferometer was installed at the BL13W beamline of Shanghai Synchrotron Radiation Facility (SSRF) for biomedical imaging applications. Compared with imaging results from conventional absorption-based micro-computed tomography, this set-up has shown much better soft tissue imaging capability. In particular, using the set-up, the carotid artery and the carotid vein in a formalin-fixed mouse can be visualized in situ without contrast agents, paving the way for future applications in cancer angiography studies. The overall results have demonstrated the broad prospects of the existing set-up for biomedical imaging applications at SSRF.

[1]  Atsushi Momose,et al.  Demonstration of X-Ray Talbot Interferometry , 2003 .

[2]  Richard Solomon,et al.  Contrast Media and Nephropathy: Findings From Systematic Analysis and Food and Drug Administration Reports of Adverse Effects , 2006, Investigative radiology.

[3]  O. Bunk,et al.  Hard x-ray phase tomography with low-brilliance sources. , 2007, Physical review letters.

[4]  Timm Weitkamp,et al.  Two-dimensional x-ray grating interferometer. , 2010, Physical review letters.

[5]  Franz Pfeiffer,et al.  Development of a prototype gantry system for preclinical x-ray phase-contrast computed tomography. , 2011, Medical physics.

[6]  Richard J. Fitzgerald,et al.  Phase‐Sensitive X‐Ray Imaging , 2000 .

[7]  C. David,et al.  The First Analysis and Clinical Evaluation of Native Breast Tissue Using Differential Phase-Contrast Mammography , 2011, Investigative radiology.

[8]  Franz Pfeiffer,et al.  X-ray phase radiography and tomography of soft tissue using grating interferometry. , 2008, European journal of radiology.

[9]  S W Wilkins,et al.  Phase-contrast radiography. , 1998, Radiographics : a review publication of the Radiological Society of North America, Inc.

[10]  A Bravin,et al.  High-resolution brain tumor visualization using three-dimensional x-ray phase contrast tomography , 2007, Physics in medicine and biology.

[11]  Jun Zhao,et al.  Microbubbles as contrast agent for in-line x-ray phase-contrast imaging , 2011 .

[12]  Atsushi Momose,et al.  Phase Tomography by X-ray Talbot Interferometry for Biological Imaging , 2006 .

[13]  Manuel Sanchez del Rio,et al.  Status of XOP: an x-ray optics software toolkit , 2004, SPIE Optics + Photonics.

[14]  K. Hyodo,et al.  Visualization, quantification and therapeutic evaluation of angiogenic vessels in cancer by synchrotron microangiography. , 2000, Journal of synchrotron radiation.

[15]  Ziyu Wu,et al.  Low-dose, simple, and fast grating-based X-ray phase-contrast imaging , 2010, Proceedings of the National Academy of Sciences.

[16]  Franz Pfeiffer,et al.  X-ray phase imaging with a grating interferometer. , 2005, Optics express.

[17]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[18]  K K W Siu,et al.  Dynamic imaging of the lungs using x-ray phase contrast , 2005, Physics in medicine and biology.

[19]  R. Lewis,et al.  Medical phase contrast x-ray imaging: current status and future prospects. , 2004, Physics in medicine and biology.

[20]  O. Bunk,et al.  Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources , 2006 .