Influence of the Hydrodynamic Environment on Quorum Sensing in Pseudomonas aeruginosa Biofilms (cid:1) †

We provide experimental and modeling evidence that the hydrodynamic environment can impact quorum sensing (QS) in a Pseudomonas aeruginosa biofilm. The amount of biofilm biomass required for full QS induction of the population increased as the flow rate increased. Quorum sensing (QS), or intercellular signaling, is used by a wide range of bacterial species to coordinate gene expression in a population 26). One of the best-studied QS mecha-nisms is the acyl homoserine-lactone (AHL) system used by many different gram-negative bacterial species QS has been characterized primarily in planktonic batch culture, where its corresponds to a specific population density at which an inducing concentration of occurs. the description of as a density-dependent

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