Sulfation of endogenous compounds and xenobiotics--interactions and function in health and disease.

Sulfation is a major detoxication mechanism for endogenous compounds and xenobiotics performed by a family of sulfotransferase isoenzymes. Understanding the normal cellular functions of these different sulfotransferases and the way in which endogenous and exogenous factors are able to influence their activity and expression will provide us with the information necessary to develop novel therapeutic strategies for conditions where sulfation may be implicated. This concept is discussed and is illustrated by examples including adverse drug reactions, fetal development and cancer.

[1]  R. Hobkirk.  Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles. , 1985, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire.

[2]  M. Sporn,et al.  Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. , 1990, Development.

[3]  I. Henderson,et al.  Cancer of the breast: the past decade (first of two parts). , 1980, The New England journal of medicine.

[4]  R. Weinshilboum,et al.  Cholesterol sulfation in human liver. Catalysis by dehydroepiandrosterone sulfotransferase. , 1993, Drug metabolism and disposition: the biological fate of chemicals.

[5]  N. Kaplowitz,et al.  Purification of a 32.5 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroids , 1986, FEBS letters.

[6]  R. Hume,et al.  Estrogen and phenol sulfotransferase activities in human fetal lung. , 1992, Early human development.

[7]  M. Coughtrie,et al.  Purification and immunochemical characterization of a male-specific rat liver oestrogen sulphotransferase. , 1993, The Biochemical journal.

[8]  R. Hume,et al.  Immunochemical characterisation of a dehydroepiandrosterone sulfotransferase in rats and humans. , 1993, European journal of biochemistry.

[9]  M. Sporn,et al.  Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. , 1990, British Journal of Cancer.

[10]  R. Hume,et al.  Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes. , 1994, Endocrinology.

[11]  J. Torday,et al.  Coordination of growth and differentiation in the fetal lung. , 1990, Experimental cell research.

[12]  C. Falany.  Molecular enzymology of human liver cytosolic sulfotransferases. , 1991, Trends in pharmacological sciences.

[13]  B. Chatterjee,et al.  Estrogen sulfotransferase of the rat liver: complementary DNA cloning and age- and sex-specific regulation of messenger RNA. , 1992, Molecular endocrinology.

[14]  R. Weinshilboum,et al.  Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. , 1992, Molecular pharmacology.

[15]  Y. Abul-Hajj.  Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma , 1975, Steroids.

[16]  M. Coughtrie,et al.  Purification and immunochemical characterization of a rat liver sulphotransferase conjugating paracetamol. , 1990, Biochemical pharmacology.

[17]  J. Beaumont,et al.  Oral Contraception, Circulating Immune Complexes, Antiethinylestradiol Antibodies, and Thrombosis * , 1982, American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction.

[18]  K. A. Comer,et al.  Human liver steroid sulphotransferase sulphates bile acids. , 1990, The Biochemical journal.

[19]  F. Labrie,et al.  Cloning and expression of cDNA encoding human placental estrogen sulfotransferase , 1994, Molecular and Cellular Endocrinology.

[20]  Takashi Suzuki,et al.  PURIFICATION AND PROPERTIES OF ESTROGEN SULEOTRANSFERASE OF HUMAN FETAL LIVER , 1993 .

[21]  A. Jones,et al.  Common food additives are potent inhibitors of human liver 17 alpha-ethinyloestradiol and dopamine sulphotransferases. , 1993, Biochemical pharmacology.

[22]  K. A. Comer,et al.  Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase. , 1993, Molecular pharmacology.

[23]  C. Falany,et al.  Purification and characterization of human liver phenol-sulfating phenol sulfotransferase. , 1990, Archives of biochemistry and biophysics.

[24]  J. Torday.  Androgens delay human fetal lung maturation in vitro. , 1990, Endocrinology.