Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

[1]  Gerome Breen,et al.  Genetic identification of brain cell types underlying schizophrenia , 2017, Nature Genetics.

[2]  S. Linnarsson,et al.  Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways , 2018, Nature Genetics.

[3]  B. Feige,et al.  Insomnia—perchance a dream? Results from a NREM/REM sleep awakening study in good sleepers and patients with insomnia , 2018, Sleep.

[4]  Robert M. Maier,et al.  Causal associations between risk factors and common diseases inferred from GWAS summary data , 2017, Nature Communications.

[5]  E. V. van Someren,et al.  Insomnia heterogeneity: Characteristics to consider for data-driven multivariate subtyping. , 2017, Sleep medicine reviews.

[6]  Erdogan Taskesen,et al.  Functional mapping and annotation of genetic associations with FUMA , 2017, Nature Communications.

[7]  Stephen H. Bell,et al.  Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry , 2022 .

[8]  B. Feige,et al.  Insomnia with objective short sleep duration is associated with longer duration of insomnia in the Freiburg Insomnia Cohort compared to insomnia with normal sleep duration, but not with hypertension , 2017, PloS one.

[9]  Robert Plomin,et al.  Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence , 2017, Nature Genetics.

[10]  H. Stefánsson,et al.  Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits , 2017, Nature Genetics.

[11]  M. Montico,et al.  SNCA 3′UTR genetic variants in patients with Parkinson’s disease and REM sleep behavior disorder , 2017, Neurological Sciences.

[12]  A. Hofman,et al.  Identification of context-dependent expression quantitative trait loci in whole blood , 2016, Nature Genetics.

[13]  Helen E. Parkinson,et al.  The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog) , 2016, Nucleic Acids Res..

[14]  Xiaofeng Zhu,et al.  Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits , 2016, Nature Genetics.

[15]  Y. D. van der Werf,et al.  I Keep a Close Watch on This Heart of Mine: Increased Interoception in Insomnia. , 2016, Sleep.

[16]  Anthony D. Schmitt,et al.  A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome. , 2016, Cell reports.

[17]  Andres Metspalu,et al.  Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci , 2016, PLoS genetics.

[18]  R. McIntyre,et al.  Mapping inflammation onto mood: Inflammatory mediators of anhedonia , 2016, Neuroscience & Biobehavioral Reviews.

[19]  E. Tagliazucchi,et al.  Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia. , 2016, Sleep.

[20]  T. Heskes,et al.  The statistical properties of gene-set analysis , 2016, Nature Reviews Genetics.

[21]  Max A. Little,et al.  Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank , 2016, Nature Communications.

[22]  B. Feige,et al.  Slow dissolving of emotional distress contributes to hyperarousal , 2016, Proceedings of the National Academy of Sciences.

[23]  N. Eriksson,et al.  GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person , 2016, Nature Communications.

[24]  J. Mesirov,et al.  The Molecular Signatures Database Hallmark Gene Set Collection , 2015 .

[25]  Allan R. Jones,et al.  Canonical Genetic Signatures of the Adult Human Brain , 2015, Nature Neuroscience.

[26]  P. Visscher,et al.  Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores , 2015, bioRxiv.

[27]  Yakir A Reshef,et al.  Partitioning heritability by functional annotation using genome-wide association summary statistics , 2015, Nature Genetics.

[28]  K. Kendler,et al.  A Longitudinal Twin Study of Insomnia Symptoms in Adults. , 2015, Sleep.

[29]  Jun S. Liu,et al.  The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans , 2015, Science.

[30]  Paul Antoine Salin,et al.  The supramammillary nucleus and the claustrum activate the cortex during REM sleep , 2015, Science Advances.

[31]  Joris M. Mooij,et al.  MAGMA: Generalized Gene-Set Analysis of GWAS Data , 2015, PLoS Comput. Biol..

[32]  M. Butler,et al.  High-Resolution Chromosome Ideogram Representation of Currently Recognized Genes for Autism Spectrum Disorders , 2015, International Journal of Molecular Sciences.

[33]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[34]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[35]  Jack Euesden,et al.  PRSice: Polygenic Risk Score software , 2014, Bioinform..

[36]  C. Nievergelt,et al.  Genetic variants associated with sleep disorders , 2014, Sleep medicine.

[37]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[38]  Rachel Manber,et al.  Insomnia disorder , 2015, Nature Reviews Disease Primers.

[39]  M. Chesselet,et al.  Sleep Dysfunction and EEG Alterations in Mice Overexpressing Alpha-Synuclein , 2018, Journal of Parkinson's disease.

[40]  Yi-Xiang J. Wang,et al.  Altered intrinsic regional brain spontaneous activity and subjective sleep quality in patients with chronic primary insomnia: a resting-state fMRI study , 2014, Neuropsychiatric disease and treatment.

[41]  Brian N. Mathur,et al.  The claustrum in review , 2014, Front. Syst. Neurosci..

[42]  J. Shendure,et al.  A general framework for estimating the relative pathogenicity of human genetic variants , 2014, Nature Genetics.

[43]  Y. D. van der Werf,et al.  The caudate: a key node in the neuronal network imbalance of insomnia? , 2013, Brain : a journal of neurology.

[44]  K. Safranow,et al.  The BTBD9 gene polymorphisms in Polish patients with Gilles de la Tourette syndrome. , 2014, Acta neurobiologiae experimentalis.

[45]  M. Peters,et al.  Systematic identification of trans eQTLs as putative drivers of known disease associations , 2013, Nature Genetics.

[46]  R. Greene,et al.  Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice , 2013, Proceedings of the National Academy of Sciences.

[47]  Jun Lu,et al.  How do the basal ganglia regulate sleep–wake behavior? , 2012, Trends in Neurosciences.

[48]  T. van Groen,et al.  Motor restlessness, sleep disturbances, thermal sensory alterations and elevated serum iron levels in Btbd9 mutant mice. , 2012, Human molecular genetics.

[49]  H. Jinnah,et al.  Sleep Fragmentation and Motor Restlessness in a Drosophila Model of Restless Legs Syndrome , 2012, Current Biology.

[50]  J. Sweatt,et al.  Enhanced Hippocampal Long-Term Potentiation and Fear Memory in Btbd9 Mutant Mice , 2012, PloS one.

[51]  Manolis Kellis,et al.  ChromHMM: automating chromatin-state discovery and characterization , 2012, Nature Methods.

[52]  J. Os,et al.  The size and burden of mental disorders and other disorders of the brain in Europe 2010 , 2011, European Neuropsychopharmacology.

[53]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[54]  Nicholas Eriksson,et al.  Efficient Replication of over 180 Genetic Associations with Self-Reported Medical Data , 2011, PloS one.

[55]  Helga Thorvaldsdóttir,et al.  Molecular signatures database (MSigDB) 3.0 , 2011, Bioinform..

[56]  M. Qiu,et al.  Role of Basal Ganglia in Sleep–Wake Regulation: Neural Circuitry and Clinical Significance , 2010, Frontiers in Neuroanatomy.

[57]  T. Paparrigopoulos,et al.  Insomnia and its correlates in a representative sample of the Greek population , 2010, BMC public health.

[58]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[59]  H. Hakonarson,et al.  ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.

[60]  Brian T. Naughton,et al.  Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits , 2010, PLoS genetics.

[61]  Eden R Martin,et al.  Genome‐Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease , 2010, Annals of human genetics.

[62]  M. Qiu,et al.  Basal ganglia control of sleep–wake behavior and cortical activation , 2010, The European journal of neuroscience.

[63]  Seung Bong Hong,et al.  Epidemiology of Insomnia in Korean Adults: Prevalence and Associated Factors , 2009, Journal of clinical neurology.

[64]  S. Rombouts,et al.  Prefrontal hypoactivation and recovery in insomnia. , 2008, Sleep.

[65]  I. Borecki,et al.  Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; The NHLBI Family Heart Study , 2008, BMC Medical Genetics.

[66]  Kari Stefansson,et al.  A genetic risk factor for periodic limb movements in sleep. , 2007, The New England journal of medicine.

[67]  P. Croft,et al.  Epidemiology of insomnia: a longitudinal study in a UK population. , 2007, Sleep.

[68]  Bin Zhang,et al.  Sex differences in insomnia: a meta-analysis. , 2006, Sleep.

[69]  C. Saper,et al.  Hypothalamic regulation of sleep and circadian rhythms , 2005, Nature.

[70]  B Marshall,et al.  Gene Ontology Consortium: The Gene Ontology (GO) database and informatics resource , 2004, Nucleic Acids Res..

[71]  Kimberly Van Auken,et al.  WormBase: a multi-species resource for nematode biology and genomics , 2004, Nucleic Acids Res..

[72]  A. Krystal,et al.  NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. , 2002, Sleep.

[73]  Charles J. Wilson,et al.  Spontaneous firing patterns of identified spiny neurons in the rat neostriatum , 1981, Brain Research.