Birth outcomes of infants born in areas with elevated ambient exposure to incinerator generated PCDD/Fs.

The purpose of this study was to determine if elevated ambient exposure to incinerator generated polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) may affect birth outcomes of exposed infants born in Taipei metropolitan areas, Taiwan. The relationships between exposure to elevated PCDD/Fs concentration and various birth outcomes including birth weight, gestational age, and proportion of females were cross-sectionally assessed in 1991 (one year before the incinerator started to operate) and 1997 (five years later), respectively. We used the US EPA Industrial Source Complex Model-Sort Term modeling technique to determine the ambient PCDD/Fs concentrations in the study areas, in which 40 districts with annual averaged PCDD/Fs exposure of > or = 0.03 pg TEQ/m3 were considered as the exposed areas and another 40 districts with an estimated concentration of zero were randomly selected as reference areas. Information on birth outcomes was retrieved from the Taiwan's Birth Registry. A total of 6697 and 6282 neonates were included in the analysis for 1991 and 1997, respectively. After controlling for potential confounders, the results showed that the odds ratios (ORs) of low birth weight (< 2500 g) for higher exposures were 0.94 (> 0.05 pg TEQ/m3) and 091 (0.03-0.05 pg TEQ/m3) in 1991 and were 1.07 (> 0.05 pg TEQ/m3) and 1.06 (0.03-0.05 pg TEQ/m3) in 1997. The corresponding ORs were 1.05/0.86 (1991) and 1.12/1.22 (1997) for preterm (< 37 completed weeks of gestation), as well as 0.95/1.00 (1991) and 0.95/0.90 (1997) for female births. The above ORs were all close to unity and were statistically insignificant. When birth weight was analyzed as a continuous variable, the difference in mean birth weight between exposed group (> 0.03 pg TEQ/m3) and reference group decreased from 3.02 g in 1991 to -5.87 g in 1997. Analysis of continuous data also showed that the mean difference in gestational age between exposed and reference areas decreased from 0.05 weeks in 1991 to -0.09 week (p<0.05) in 1997. This study tends to conclude that the incinerator generated dioxin poses little effects on birth weight and female birth, but might pose small effects on gestational age. If the observed adverse effects turn out to be real, the measures now taken for improvement of abatement of waste gases seem to be a wise thing to do.

[1]  D J Paustenbach,et al.  Evaluation of potential transmission of 2,3,7,8-tetrachlorodibenzo-p-dioxin-contaminated incinerator emissions to humans via foods. , 1990, Journal of toxicology and environmental health.

[2]  B. Woolf.  ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASE , 1955, Annals of human genetics.

[3]  M. Hadders‐Algra,et al.  Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development. , 1995, Early human development.

[4]  R. Bertollini,et al.  Birth Defects in the Seveso Area After TCDD Contamination , 1988 .

[5]  G. Eduljee,et al.  Validation of a methodology for modelling PCDD and PCDF intake via the foodchain. , 1996, The Science of the total environment.

[6]  M. S. Ho,et al.  Urban-rural and regional differences in infant mortality in Taiwan. , 1994, Social science & medicine.

[7]  S. Ratti,et al.  A two-exponential model to describe the vanishing trend of 2,3,7,8-tetrachlorodibenzodioxin (TCDD) in the soil at Seveso, northern Italy. , 1990 .

[8]  L. Hagmar,et al.  Lowered birth weight among infants born to women with a high intake of fish contaminated with persistent organochlorine compounds. , 2000, Chemosphere.

[9]  Laurie A. Piacitelli,et al.  Paternal Occupational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Birth Outcomes of Offspring: Birth Weight, Preterm Delivery, and Birth Defects , 2004, Environmental health perspectives.

[10]  F. Speizer,et al.  Maternal smoking during pregnancy, urine cotinine concentrations, and birth outcomes. A prospective cohort study. , 1997, International journal of epidemiology.

[11]  L. Hagmar,et al.  Dietary intake of fish contaminated with persistent organochlorine compounds in relation to low birthweight. , 1996, Scandinavian journal of work, environment & health.

[12]  L. Hagmar,et al.  Decreased birthweight among infants born to women with a high dietary intake of fish contaminated with persistent organochlorine compounds. , 1995, Scandinavian journal of work, environment & health.

[13]  G. Lucier,et al.  Decreased human birth weights after in utero exposure to PCBs and PCDFs are associated with decreased placental EGF-stimulated receptor autophosphorylation capacity. , 1987, Molecular pharmacology.

[14]  Gev Eduljee,et al.  An updated inventory of potential PCDD and PCDF emission sources in the UK , 1996 .

[15]  H. Tryphonas.  The impact of PCBs and dioxins on children's health: immunological considerations. , 1998, Canadian journal of public health = Revue canadienne de sante publique.

[16]  L. Edmonds,et al.  Reproductive outcomes of mothers with potential exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1988, American journal of epidemiology.

[17]  K. Olie,et al.  Effects of pre- and postnatal exposure to chlorinated dioxins and furans on human neonatal thyroid hormone concentrations. , 1993, Environmental health perspectives.

[18]  P. Brambilla,et al.  Paternal concentrations of dioxin and sex ratio of offspring , 2000, The Lancet.

[19]  B. Eskenazi,et al.  Maternal serum dioxin levels and birth outcomes in women of Seveso, Italy. , 2003, Environmental health perspectives.

[20]  P. Pinsky,et al.  Relationships between dioxins in soil, air, ash, and emissions from a municipal solid waste incinerator emitting large amounts of dioxins. , 1998, Chemosphere.

[21]  G L Kimmel,et al.  Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisons. , 1993, Critical reviews in toxicology.

[22]  Matthew Lorber,et al.  A Screening Level Risk Assessment of the Indirect Impacts From the Columbus Waste to Energy Facility in Columbus, Ohio , 1996 .

[23]  P. Liao,et al.  Associations between dietary intake and serum polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F) levels in Taiwanese. , 2003, Environmental research.

[24]  L. Needham,et al.  Dioxin incinerator emissions exposure study Times Beach, Missouri. , 2000, Chemosphere.

[25]  S. Thacker.  Fraudulent Studies and Meta-analysis-Reply , 1988 .

[26]  C. Koopman‐Esseboom,et al.  Effects of Environmental Exposure to Polychlorinated Biphenyls and Dioxins on Birth Size and Growth in Dutch Children , 1998, Pediatric Research.

[27]  S. Teng,et al.  Validation of the Taiwan Birth Registry using obstetric records. , 2004, Journal of the Formosan Medical Association = Taiwan yi zhi.