The Study of Magnesium Substitution Effect on Physicochemical Properties of Hydroxyapatite

In the present study, pure and Mg-substituted hydroxyapatite powders made up of needle-like and plate-like particles, respectively, have been synthesized by wet chemical precipitation of CaO, MgO and H3PO4. The influence of different amounts of MgO addition into synthesis media on properties of as-synthesized and sintered powders has been evaluated. Through the phase and chemical composition analysis it has been determined that the prepared powders contain various amounts of Mg (in the range between 0.21–4.72 wt%). The substitution of Mg promoted the decomposition of hydroxyapatite to β-tricalcium phosphate.

[1]  C. Marchetti,et al.  Magnesium-substituted hydroxyapatite grafting using the vertical inlay technique. , 2013, The International journal of periodontics & restorative dentistry.

[2]  F. Mauri,et al.  Magnesium incorporation into hydroxyapatite. , 2011, Biomaterials.

[3]  Y. Leng,et al.  Synthesis, characterization and ab initio simulation of magnesium-substituted hydroxyapatite. , 2010, Acta biomaterialia.

[4]  M. Gazzano,et al.  Ionic substitutions in calcium phosphates synthesized at low temperature. , 2010, Acta biomaterialia.

[5]  M. Lombardi,et al.  Mg-substituted hydroxyapatite nanopowders: Synthesis, thermal stability and sintering behaviour , 2009 .

[6]  Avinash Balakrishnan,et al.  Synthesis of nano hydroxyapatite powder that simulate teeth particle morphology and composition , 2009 .

[7]  K. Matsunaga.  First-principles study of substitutional magnesium and zinc in hydroxyapatite and octacalcium phosphate. , 2008, The Journal of chemical physics.

[8]  Anna Tampieri,et al.  Biomimetic Mg-substituted hydroxyapatite: from synthesis to in vivo behaviour , 2008, Journal of materials science. Materials in medicine.

[9]  Anna Tampieri,et al.  Biomimetic Mg- and Mg,CO3-substituted hydroxyapatites: synthesis characterization and in vitro behaviour , 2006 .

[10]  I. Pasuk,et al.  The study of Mg2+ /Ca2+ substitution of β-tricalcium phosphate , 2006 .

[11]  K. Byrappa,et al.  Preparation of magnesium-substituted hydroxyapatite powders by the mechanochemical-hydrothermal method. , 2004, Biomaterials.

[12]  M. Vallet‐Regí,et al.  Hydroxyapatite, tricalcium phosphate and biphasic materials prepared by a liquid mix technique , 2003 .

[13]  V. Orlovskii,et al.  Synthesis and Structure of Magnesium-Substituted Hydroxyapatite , 2003 .

[14]  S. R. Kim,et al.  Synthesis of Si, Mg substituted hydroxyapatites and their sintering behaviors. , 2003, Biomaterials.

[15]  T. Albrektsson,et al.  Osteoinduction, osteoconduction and osseointegration , 2001, European Spine Journal.

[16]  J. Featherstone,et al.  Magnesium-containing carbonate apatites. , 1997, Journal of inorganic biochemistry.