Proteomic and Functional Analyses Reveal a Mitochondrial Dysfunction in P301L Tau Transgenic Mice*
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R. Ravid | P. Rizzu | J. Götz | D. David | U. Brandt | W. Müller | A. Eckert | S. Dröse | S. Hauptmann | I. Scherping | K. Schuessel | U. Keil | Della C. David | W. Müller
[1] T. Bayer,et al. Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice , 2005, Neurobiology of Disease.
[2] P. Greengard,et al. Different Presynaptic Roles of Synapsins at Excitatory and Inhibitory Synapses , 2004, The Journal of Neuroscience.
[3] C. Haass,et al. Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis* , 2004, Journal of Biological Chemistry.
[4] L. Landino,et al. Redox modulation of tau and microtubule-associated protein-2 by the glutathione/glutaredoxin reductase system. , 2004, Biochemical and biophysical research communications.
[5] A. Drzezga,et al. Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study , 2004, Neurobiology of Aging.
[6] Armin Scheurich,et al. Association of elevated phospho-tau levels with alzheimer-typical 18F-Fluoro-2-Deoxy-D-Glucose positron emission tomography findings in patients with mild cognitive impairment , 2004, Biological Psychiatry.
[7] L. Landino,et al. Cysteine Oxidation of Tau and Microtubule-associated Protein-2 by Peroxynitrite , 2004, Journal of Biological Chemistry.
[8] M. Beal,et al. Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[9] J. Streffer,et al. Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy , 2004, Molecular Psychiatry.
[10] A. Drzezga,et al. Region-Specific Decline of Cerebral Glucose Metabolism in Patients with Frontotemporal Dementia: A Prospective 18F-FDG-PET Study , 2004, Dementia and Geriatric Cognitive Disorders.
[11] N. Cairns,et al. Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer’s disease brain , 2004, Journal of Neural Transmission.
[12] R. Nitsch,et al. Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice , 2004, Neurobiology of Disease.
[13] Eden R Martin,et al. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. , 2003, Human molecular genetics.
[14] T. Bayer,et al. Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice , 2003, Experimental Neurology.
[15] D. Butterfield,et al. Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration , 2003, Journal of neurochemistry.
[16] J. Trojanowski,et al. Enhanced brain levels of 8,12-iso-iPF2α-VI differentiate AD from frontotemporal dementia , 2003, Neurology.
[17] Richard F. Thompson,et al. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[18] Visith Thongboonkerd,et al. Proteomic identification of nitrated proteins in Alzheimer's disease brain , 2003, Journal of neurochemistry.
[19] E. R. Taylor,et al. Reversible Glutathionylation of Complex I Increases Mitochondrial Superoxide Formation* , 2003, Journal of Biological Chemistry.
[20] M. Robin,et al. Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells , 2003, The Journal of cell biology.
[21] A. Delacourte,et al. Association of atp synthase α-chain with neurofibrillary degeneration in alzheimer’s disease , 2003, Neuroscience.
[22] T. Russo,et al. Signal Transduction through Tyrosine‐Phosphorylated Carboxy‐Terminal Fragments of APP via an Enhanced Interaction with Shc/Grb2 Adaptor Proteins in Reactive Astrocytes of Alzheimer's Disease Brain , 2002, Annals of the New York Academy of Sciences.
[23] Xiongwei Zhu,et al. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau , 2002, Neurobiology of Aging.
[24] K. Kaibuchi,et al. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly , 2002, Nature Cell Biology.
[25] G. Sobue,et al. Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease , 2002, Acta Neuropathologica.
[26] Peter Lipp,et al. Mitochondria are morphologically and functionally heterogeneous within cells , 2002, The EMBO journal.
[27] J. Land,et al. β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities , 2001, Journal of neurochemistry.
[28] R. Faull,et al. Proteomic analysis of the brain in Alzheimer’s disease: Molecular phenotype of a complex disease process , 2001, Proteomics.
[29] R. Nitsch,et al. Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils , 2001, Science.
[30] K. Kaibuchi,et al. CRMP-2 induces axons in cultured hippocampal neurons , 2001, Nature Neuroscience.
[31] N. Cairns,et al. The reduction of NADH ubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease. , 2001, Life sciences.
[32] B. Winblad,et al. The Cerebrocortical Areas in Normal Brain Aging and in Alzheimer's Disease: Noticeable Differences in the Lipid Peroxidation Level and in Antioxidant Defense , 2001, Neurochemical Research.
[33] N. Cairns,et al. Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease. , 2001, Biochemical and biophysical research communications.
[34] R. Nitsch,et al. Tau Filament Formation in Transgenic Mice Expressing P301L Tau* , 2001, The Journal of Biological Chemistry.
[35] I. Lemahieu,et al. Differential Regional Cerebral Uptake of 18F-Fluoro-2-Deoxy-D-Glucose in Alzheimer’s Disease and Frontotemporal Dementia at Initial Diagnosis , 2001, European Neurology.
[36] G. Perry,et al. Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4‐hydroxy‐2‐nonenal , 2000, FEBS letters.
[37] M. Kinoshita,et al. Differential localization of septins in the mouse brain , 2000, The Journal of comparative neurology.
[38] Wen-Lang Lin,et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein , 2000, Nature Genetics.
[39] E B Mukaetova-Ladinska,et al. Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. , 2000, The American journal of pathology.
[40] M. Radermacher,et al. Biophysical and structural characterization of proton-translocating NADH-dehydrogenase (complex I) from the strictly aerobic yeast Yarrowia lipolytica. , 2000, Biochimica et biophysica acta.
[41] U. F. Rasmussen,et al. Human quadricepts muscle mitochondria: A functional characterization , 2000, Molecular and Cellular Biochemistry.
[42] S. Menini,et al. Lipoperoxidation Is Selectively Involved in Progressive Supranuclear Palsy , 2000, Journal of neuropathology and experimental neurology.
[43] Luis Moroder,et al. Structure of TPR Domain–Peptide Complexes Critical Elements in the Assembly of the Hsp70–Hsp90 Multichaperone Machine , 2000, Cell.
[44] M. Goedert,et al. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) , 2000, Neurogenetics.
[45] J. Kovács,et al. Enhanced association of mutant triosephosphate isomerase to red cell membranes and to brain microtubules. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[46] C. Culmsee,et al. Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases , 1999, Annals of the New York Academy of Sciences.
[47] J. Prehn,et al. Mitochondrial Depolarization Is Not Required for Neuronal Apoptosis , 1999, The Journal of Neuroscience.
[48] D. Butterfield,et al. The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase, and NADH Dehydrogenase, in Different Brain Regions in Alzheimer's Disease , 1999, Neurochemical Research.
[49] R. Bowser,et al. The septin CDCrel-1 binds syntaxin and inhibits exocytosis , 1999, Nature Neuroscience.
[50] Mark A. Smith,et al. Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli , 1999, Brain Research.
[51] C Xie,et al. Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease , 1998, Neurology.
[52] E. Mandelkow,et al. Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease , 1998, The Journal of cell biology.
[53] A Klug,et al. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[54] Ronald C. Petersen,et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 , 1998, Nature.
[55] G. Schellenberg,et al. Tau is a candidate gene for chromosome 17 frontotemporal dementia , 1998, Annals of neurology.
[56] H. Akiyama,et al. Identification of septins in neurofibrillary tangles in Alzheimer's disease. , 1998, The American journal of pathology.
[57] G. Davey,et al. Energy Thresholds in Brain Mitochondria , 1998, The Journal of Biological Chemistry.
[58] D. Hochstrasser,et al. Extraction of membrane proteins by differential solubilization for separation using two‐dimensional gel electrophoresis , 1998, Electrophoresis.
[59] Y. Ihara,et al. Collapsin Response Mediator Protein-2 Is Associated with Neurofibrillary Tangles in Alzheimer’s Disease* , 1998, The Journal of Biological Chemistry.
[60] M. Freedman,et al. Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease , 1998, Experimental Neurology.
[61] J. Kocsis,et al. Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root Ganglia In Vivo , 1998, The Journal of Neuroscience.
[62] S. Budd,et al. Mitochondrial membrane potential and hydroethidine‐monitored superoxide generation in cultured cerebellar granule cells , 1997, FEBS letters.
[63] M. Mattson,et al. Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal , 1997, Journal of neurochemistry.
[64] Mark A. Smith,et al. 4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease , 1997, Journal of neurochemistry.
[65] R. DeTeresa,et al. Neurofibrillary tangle-associated alteration of stathmin in Alzheimer's disease , 1996, Neurobiology of Aging.
[66] G. Davey,et al. Threshold Effects and Control of Oxidative Phosphorylation in Nonsynaptic Rat Brain Mitochondria , 1996, Journal of neurochemistry.
[67] W. D. Ehmann,et al. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease , 1995, Neurology.
[68] H. Schägger,et al. Human diseases with defects in oxidative phosphorylation. 2. F1F0 ATP-synthase defects in Alzheimer disease revealed by blue native polyacrylamide gel electrophoresis. , 1995, European journal of biochemistry.
[69] M. Beal,et al. Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease , 1994, Journal of neurochemistry.
[70] M. Beal,et al. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. , 1994, Genomics.
[71] M. Mattson,et al. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[72] C. Nebot,et al. Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol. , 1993, Analytical biochemistry.
[73] I. Ceballos-Picot,et al. 4-Hydroxynonenal content lower in brains of 25 month old transgenic mice carrying the human CuZn superoxide dismutase gene than in brains of their non-transgenic littermates. , 1993, Journal of lipid mediators.
[74] B. Crain,et al. Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. , 1993, Genomics.
[75] D. Price,et al. Age‐Dependent Impairment of Mitochondrial Function in Primate Brain , 1993, Journal of neurochemistry.
[76] W. Müller,et al. Age-related deficits of central muscarinic cholinergic receptor function in the mouse: Partial restoration by chronic piracetam treatment , 1992, Neurobiology of Aging.
[77] W. Jagust,et al. Diminished Glucose Transport in Alzheimer's Disease: Dynamic PET Studies , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[78] M. Brammer,et al. Brain membrane fluidity and lipid peroxidation in Alzheimer's disease , 1990, Neuroscience Letters.
[79] D. Neary,et al. Mitochondrial function in brain tissue in primary degenerative dementia , 1987, Brain Research.
[80] M. Comporti. Glutathione depleting agents and lipid peroxidation. , 1987, Chemistry and physics of lipids.
[81] D. Neary,et al. AN ULTRASTRUCTURAL ANALYSIS OF THE EFFECTS OF ACCUMULATION OF NEUROFIBRILLARY TANGLE IN PYRAMIDAL NEURONS OF THE CEREBRAL CORTEX IN ALZHEIMER'S DISEASE , 1986, Neuropathology and applied neurobiology.
[82] K. Ohta,et al. Regional Distributions of Thiobarbituric Acid‐Reactive Products, Activities of Enzymes Regulating the Metabolism of Oxygen Free Radicals, and Some of the Related Enzymes in Adult and Aged Rat Brains , 1986, Journal of neurochemistry.
[83] F. Ursini,et al. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. , 1985, Biochimica et biophysica acta.
[84] J. Gutteridge,et al. Lipid peroxidation initiated by superoxide‐dependent hydroxyl radicals using complexed iron and hydrogen peroxide , 1984, FEBS letters.
[85] J. Gutteridge,et al. Superoxide-dependent lipid peroxidation. Problems with the use of catalase as a specific probe for fenton-derived hydroxyl radicals. , 1983, Biochemical and biophysical research communications.
[86] J. Turrens,et al. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. , 1980, The Biochemical journal.
[87] W. Valentine,et al. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. , 1967, The Journal of laboratory and clinical medicine.
[88] Oliver H. Lowry,et al. Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.
[89] J. Trojanowski,et al. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. , 2004, The American journal of pathology.
[90] R. Kozłowski,et al. The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. , 1993, Journal of immunological methods.
[91] H. Esterbauer,et al. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. , 1990, Methods in enzymology.
[92] P. Tarroux,et al. Improvement and simplification of low‐background silver staining of proteins by using sodium dithionite , 1988, Electrophoresis.