Multiple pathways for the regulation of telomerase activity.

[1]  J. Shay,et al.  Telomerase activity concentrates in the mitotically active segments of human hair follicles. , 1997, The Journal of investigative dermatology.

[2]  W. Wright,et al.  Telomeres and Telomerase: A Simple Picture Becomes Complex , 1996, Cell.

[3]  R. Effros,et al.  Mechanism of telomerase induction during T cell activation. , 1996, Experimental cell research.

[4]  C. Greider,et al.  Telomerase regulation during entry into the cell cycle in normal human T cells. , 1996, Molecular biology of the cell.

[5]  K. Riabowol,et al.  Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines. , 1996, Cancer research.

[6]  E. Greene,et al.  Processing of nontelomeric 3' ends by telomerase: default template alignment and endonucleolytic cleavage , 1996, Molecular and cellular biology.

[7]  J. Shay,et al.  Refining the telomere-telomerase hypothesis of aging and cancer , 1996, Nature Biotechnology.

[8]  J. Shay,et al.  Regulation of telomerase activity in immortal cell lines , 1996, Molecular and cellular biology.

[9]  D. Corey,et al.  Inhibition of human telomerase activity by peptide nucleic acids , 1996, Nature Biotechnology.

[10]  E. Estey,et al.  Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[11]  E. Dmitrovsky,et al.  Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines. , 1996, Cancer research.

[12]  J. Shay,et al.  Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. , 1996, The EMBO journal.

[13]  J. Shay,et al.  Detection of telomerase activity in malignant and nonmalignant skin conditions. , 1996, The Journal of investigative dermatology.

[14]  A. Gazdar,et al.  Telomerase activity in human breast tumors. , 1996, Journal of the National Cancer Institute.

[15]  E. Blackburn,et al.  Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines , 1996, Molecular and cellular biology.

[16]  D. S. Coffey,et al.  Telomerase activity: a prevalent marker of malignant human prostate tissue. , 1996, Cancer research.

[17]  J. Shay,et al.  Telomerase activity in human germline and embryonic tissues and cells. , 1996, Developmental genetics.

[18]  A. Sartorelli,et al.  Differentiation of immortal cells inhibits telomerase activity. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[19]  H. Erdjument-Bromage,et al.  A Human Telomeric Protein , 1995, Science.

[20]  J. Shay,et al.  Telomerase activity in human brain tumours , 1995, The Lancet.

[21]  J. Shay,et al.  Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. , 1995, Journal of immunology.

[22]  M. Oshimura,et al.  Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 , 1995, Japanese journal of cancer research : Gann.

[23]  D. Broccoli,et al.  Telomerase activity in normal and malignant hematopoietic cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[24]  R. Reddel,et al.  Telomere elongation in immortal human cells without detectable telomerase activity. , 1995, The EMBO journal.

[25]  A. Gazdar,et al.  Telomerase activity in small-cell and non-small-cell lung cancers. , 1995, Journal of the National Cancer Institute.

[26]  B. Leber,et al.  Telomerase activity in normal leukocytes and in hematologic malignancies. , 1995, Blood.

[27]  J. Shay,et al.  Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP) , 1995 .

[28]  Keiko Hiyama,et al.  Correlating telomerase activity levels with human neuroblastoma outcomes , 1995, Nature Medicine.

[29]  J. Shay,et al.  Mechanisms of escaping cellular senescence , 1995 .

[30]  C B Harley,et al.  Specific association of human telomerase activity with immortal cells and cancer. , 1994, Science.

[31]  C B Harley,et al.  Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[32]  J. Murnane,et al.  Telomere dynamics in an immortal human cell line. , 1994, The EMBO journal.

[33]  C. Greider,et al.  Telomerase activity in germline and embryonic cells of Xenopus. , 1994, The EMBO journal.

[34]  J. Minna,et al.  Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines. , 1994, Oncogene.

[35]  C. Harley,et al.  Telomerase activity in human ovarian carcinoma. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[36]  J. Minna,et al.  A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity. , 1993, Oncogene.

[37]  J. Shay,et al.  E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. , 1993, Oncogene.

[38]  S. Naylor,et al.  Definition of a tumor suppressor locus within human chromosome 3p21-p22. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[39]  C B Harley,et al.  Telomere length predicts replicative capacity of human fibroblasts. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[40]  C B Harley,et al.  Telomere end-replication problem and cell aging. , 1992, Journal of molecular biology.

[41]  J. Steitz,et al.  Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. , 1992, The EMBO journal.

[42]  J. Shay,et al.  A role for both RB and p53 in the regulation of human cellular senescence. , 1991, Experimental cell research.

[43]  E. Blackburn,et al.  Functional evidence for an RNA template in telomerase. , 1990, Science.

[44]  G. Morin.  The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats , 1989, Cell.

[45]  J. Shay,et al.  Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts , 1989, Molecular and cellular biology.

[46]  E. Blackburn,et al.  A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis , 1989, Nature.

[47]  J. Minna,et al.  Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23). , 1982, Science.

[48]  Olovnikov Am.  Principle of marginotomy in template synthesis of polynucleotides , 1971 .