Adiabatic TOCSY MAS in liquids.

The effect of magic angle spinning (MAS) of liquids upon the performance of various isotropic mixing sequences is investigated. Although the mathematical formalism for isotropic mixing under MAS conditions is similar for both liquids and solids, the mechanism through which the coherence transfer is disturbed is different. In liquids, the use of sample spinning in the presence of both RF and magnetic-field inhomogeneities introduces a modulation of the effective field, which compromises the performance of the conventional mixing sequences. This effect is further amplified by supercycles, which normally improve the performance of the mixing and decoupling experiments. It is demonstrated that adiabatic mixing sequences are less susceptible to such modulations and perform considerably better in TOCSY MAS experiments. The best performance of TOCSY MAS is observed under the rotational resonance condition when the sample appears static in the nutation reference frame.

[1]  Pi7, an orphan peptide from the scorpion Pandinus imperator: a 1H-NMR analysis using a nano-NMR Probe. , 1999, Biochemistry.

[2]  E. Kupče,et al.  Adiabatic mixing in the liquid state. , 1998, Journal of magnetic resonance.

[3]  P. Keifer.  NEW METHODS FOR OBTAINING HIGH-RESOLUTION NMR SPECTRA OF SOLID-PHASE SYNTHESIS RESINS, NATURAL PRODUCTS, AND SOLUTION-STATE COMBINATORIAL CHEMISTRY LI BRARIES , 1998 .

[4]  Rafael Brüschweiler,et al.  Time-resolved observation of spin waves in a linear chain of nuclear spins , 1997 .

[5]  Susanta K. Sarkar,et al.  An NMR Method To Identify Nondestructively Chemical Compounds Bound to a Single Solid-Phase-Synthesis Bead for Combinatorial Chemistry Applications , 1996 .

[6]  D. Rice,et al.  A Comparison of NMR Spectra Obtained for Solid-Phase-Synthesis Resins Using Conventional High-Resolution, Magic-Angle-Spinning, and High-Resolution Magic-Angle-Spinning Probes , 1996 .

[7]  S. Vega,et al.  A Theory for Cross-Polarization NMR of Nonspinning and Spinning Samples , 1996 .

[8]  B. Meier,et al.  Efficient N-15-C-13 polarization transfer by adiabatic-passage Hartmann-Hahn cross polarization , 1996 .

[9]  M. Goldman,et al.  Improved Versions of Off-Resonance ROESY , 1995 .

[10]  H. Köstler,et al.  Adiabatic J Cross Polarization with and without Localization , 1994 .

[11]  I. Campbell,et al.  Cool Decoupling and Mixing Wave-Forms , 1994 .

[12]  T. Barbara.  Cylindrical Demagnetization Fields and Microprobe Design in High-Resolution NMR , 1994 .

[13]  G. Bodenhausen,et al.  NMR cross polarization by adiabatic passage through the Hartmann-Hahn condition (APHH) , 1994 .

[14]  G. Bodenhausen,et al.  Selective Correlation Spectroscopy by Adiabatic Coherence Transfer , 1994 .

[15]  K. Zilm,et al.  Cross polarization with high-speed magic-angle spinning , 1993 .

[16]  R. Freeman,et al.  Multiple Hartmann-Hahn coherence transfer in nuclear magnetic resonance spectroscopy , 1992 .

[17]  M. Levitt.  Heteronuclear cross polarization in liquid‐state nuclear magnetic resonance: Mismatch compensation and relaxation behavior , 1991 .

[18]  A. Bax.  Homonuclear Hartmann-Hahn experiments. , 1989, Methods in enzymology.

[19]  T. Oas,et al.  Rotary resonance recoupling of dipolar interactions in solid‐state nuclear magnetic resonance spectroscopy , 1988 .

[20]  T. Fujiwara,et al.  Composite inversion pulses with frequency switching and their application to broadband decoupling , 1988 .

[21]  A. J. Shaka,et al.  Broadband spin decoupling in isotropic-liquids , 1987 .

[22]  John Guckenheimer,et al.  Fixed point theory of iterative excitation schemes in NMR , 1985 .

[23]  R. Freeman,et al.  Composite pulse decoupling , 1981 .

[24]  A. N. Garroway,et al.  Creation of J-ordered magnetic states by adiabatic demagnetization in the rotating frame , 1980 .

[25]  Richard R. Ernst,et al.  Coherence transfer in the rotating frame , 1979 .

[26]  D. Hoult.  Solvent peak saturation with single phase and quadrature fourier transformation , 1976 .

[27]  Peter Diehl,et al.  NMR: Basic Principles and Progress , 1969 .

[28]  E. Hahn,et al.  Nuclear Double Resonance in the Rotating Frame , 1962 .

[29]  H. Carr,et al.  The Principles of Nuclear Magnetism , 1961 .