A wireless implantable passive strain sensor system

A design study of a novel passive strain-sensor technology for the in-situ measurement of small strains on implants, bones or fixation systems is presented. The sensing principle is based on hydro-mechanical strain amplification which allows for the abandonment of any electrical circuits. Thus, the sensor can be fabricated applying solely biocompatible or bioresorbable polymeric materials. Finite element simulations are employed to validate the basic sensing principle and to optimize design parameters according to the required target specifications. Remote wireless and passive signal read-out of the sensor signal can be achieved by advanced ultrasound imaging technologies

[1]  M van der Elst,et al.  [Biodegradable implants in fracture fixation: state of the art]. , 2000, Der Unfallchirurg.

[2]  Laurie Brown,et al.  Epoxy resins as stamps for hot embossing of microstructures and microfluidic channels , 2005 .

[3]  Gang Chen,et al.  Fabrication of poly(methyl methacrylate) microfluidic chips by atmospheric molding. , 2004, Analytical chemistry.

[4]  J C Middleton,et al.  Synthetic biodegradable polymers as orthopedic devices. , 2000, Biomaterials.

[5]  G. Kotzar,et al.  Evaluation of MEMS materials of construction for implantable medical devices. , 2002, Biomaterials.

[6]  Y. Sakai,et al.  Fabrication of microstructures in photosensitive biodegradable polymers for tissue engineering applications. , 2004, Biomaterials.

[7]  Andreas Lendlein,et al.  Hydrolytic Degradation of Phase‐Segregated Multiblock Copoly(ester urethane)s Containing Weak Links , 2001 .

[8]  P. Neuenschwander,et al.  Development of degradable polyesterurethanes for medical applications: in vitro and in vivo evaluations. , 1997, Journal of biomedical materials research.

[9]  Adam T Woolley,et al.  Thermal bonding of polymeric capillary electrophoresis microdevices in water. , 2003, Analytical chemistry.

[10]  W S Pietrzak,et al.  Bioabsorbable Fixation Devices: Status for the Craniomaxillofacial Surgeon , 1997, The Journal of craniofacial surgery.

[11]  Brian J. Tighe,et al.  A review of biodegradable polymers: uses, current developments in the synthesis and characterization of biodegradable polyesters, blends of biodegradable polymers and recent advances in biodegradation studies , 1998 .

[12]  Changchun Zeng,et al.  Three‐Dimensional Assembly of Polymer Microstructures at Low Temperatures , 2004 .

[13]  P. Renaud,et al.  Polyimide and SU-8 microfluidic devices manufactured by heat-depolymerizable sacrificial material technique. , 2004, Lab on a chip.

[14]  K. Feldman,et al.  Solid‐State Replication of Relief Structures in Semicrystalline Polymers , 2000 .

[15]  D B Burr,et al.  In vivo measurement of human tibial strains during vigorous activity. , 1996, Bone.

[16]  G. Schmidt,et al.  Polymer bonding process for nanolithography , 2001 .

[17]  W S Pietrzak,et al.  Bioabsorbable Polymer Science for the Practicing Surgeon , 1997, The Journal of craniofacial surgery.

[18]  Wilhelm T. S. Huck,et al.  Microembossing of Elastomeric Triblock Copolymers , 2002 .

[19]  W S Pietrzak,et al.  Bioresorbable implants--practical considerations. , 1996, Bone.

[20]  Dirk J. Broer,et al.  Microcutting Materials on Polymer Substrates , 2002 .

[21]  Yong-Kyu Yoon,et al.  Micromachined biodegradable microstructures , 2003, The Sixteenth Annual International Conference on Micro Electro Mechanical Systems, 2003. MEMS-03 Kyoto. IEEE.

[22]  G. Whitesides,et al.  Soft Lithography. , 1998, Angewandte Chemie.