Translational control and the cancer cell response to stress.
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[1] I. Ulitsky,et al. Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress , 2017, eLife.
[2] Christos G. Gkogkas,et al. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2 , 2016, Proceedings of the National Academy of Sciences.
[3] S. Steinberg,et al. Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750—an antisense oligonucleotide against eIF4E—in combination with irinotecan in solid tumors and irinotecan‐refractory colorectal cancer , 2016, International journal of cancer.
[4] Xuemei Jiang,et al. Prognostic significance of eukaryotic initiation factor 4E in hepatocellular carcinoma , 2016, Journal of Cancer Research and Clinical Oncology.
[5] J. Seebacher,et al. Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy. , 2016, Cellular signalling.
[6] A. Kinghorn,et al. Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas. , 2016, Neuro-oncology.
[7] M. Pospíšek,et al. Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules , 2016, BMC Molecular Biology.
[8] R. Young,et al. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs , 2016, Genes & development.
[9] M. Haigis,et al. Mitochondria and Cancer , 2016, Cell.
[10] S. Ramón y. Cajal,et al. peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas , 2016, Cancer medicine.
[11] J. Doudna,et al. eIF3d is an mRNA cap-binding protein required for specialized translation initiation , 2016, Nature.
[12] R. E. Luna,et al. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation , 2016, Nucleic acids research.
[13] A. Hinnebusch,et al. Translational control by 5′-untranslated regions of eukaryotic mRNAs , 2016, Science.
[14] Chuan-Yuan Li,et al. eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation. , 2016, Cancer letters.
[15] R. Schneider,et al. Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer , 2016, Molecular Cancer Therapeutics.
[16] Davide Ruggero,et al. New frontiers in translational control of the cancer genome , 2016, Nature Reviews Cancer.
[17] Masahiro Morita,et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly , 2016, Nature Communications.
[18] J. Pelletier,et al. nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs , 2016, Genome research.
[19] J. Deddens,et al. Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma , 2016, British Journal of Cancer.
[20] Kyungho Lee,et al. Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells , 2016, Molecules and cells.
[21] A. Ballestrero,et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition , 2015, BMC Cancer.
[22] B. Jasani,et al. Phospho-4e-BP1 and eIF4E overexpression synergistically drives disease progression in clinically confined clear cell renal cell carcinoma. , 2015, American journal of cancer research.
[23] T. Tokuyasu,et al. Differential Requirements for eIF4E Dose in Normal Development and Cancer , 2015, Cell.
[24] A. Koromilas. Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment. , 2015, Biochimica et biophysica acta.
[25] P. Sorensen,et al. Stress-mediated translational control in cancer cells. , 2015, Biochimica et biophysica acta.
[26] G. Thomas,et al. A liaison between mTOR signaling, ribosome biogenesis and cancer. , 2015, Biochimica et biophysica acta.
[27] Jiangbin Ye,et al. Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress , 2015, PLoS genetics.
[28] N. Sonenberg,et al. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches , 2015, PloS one.
[29] Shuye Tian,et al. The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding. , 2015, The Biochemical journal.
[30] Eun Hee Lee,et al. Prognostic significance of phosphorylated 4E-binding protein 1 in non-small cell lung cancer. , 2015, International journal of clinical and experimental pathology.
[31] D. Speicher,et al. Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts , 2015, Cell cycle.
[32] W. Miller,et al. Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis. , 2015, Cancer research.
[33] N. Sonenberg,et al. Targeting the translation machinery in cancer , 2015, Nature Reviews Drug Discovery.
[34] D. Yee,et al. eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells. , 2015, Cancer research.
[35] D. Sabatini,et al. Nutrient-sensing mechanisms and pathways , 2015, Nature.
[36] S. Huang,et al. Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress , 2015, Cell Death and Disease.
[37] A. Eggermont,et al. eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies , 2014, Nature.
[38] N. Sonenberg,et al. Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3 , 2014, Oncogene.
[39] R. Xiang,et al. Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. , 2014, Trends in biochemical sciences.
[40] A. Tee,et al. mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3 , 2014, Oncogene.
[41] S. Kimball,et al. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1). , 2013, Cellular signalling.
[42] R. Kaufman,et al. eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies , 2013, Aging.
[43] N. Sonenberg,et al. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. , 2013, Cell metabolism.
[44] Benjamin J. Raphael,et al. Mutational landscape and significance across 12 major cancer types , 2013, Nature.
[45] B. Clarke,et al. Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3 , 2013, Clinical Cancer Research.
[46] Sofia Khan,et al. Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment , 2013, Breast Cancer Research and Treatment.
[47] S. Formenti,et al. Vitronectin-αvβ3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells. , 2013, Cancer research.
[48] E. Papadopoulos,et al. Hypoxia-inducible Factor-1α (HIF-1α) Promotes Cap-dependent Translation of Selective mRNAs through Up-regulating Initiation Factor eIF4E1 in Breast Cancer Cells under Hypoxia Conditions* , 2013, The Journal of Biological Chemistry.
[49] J. Pelletier,et al. eIF4F suppression in breast cancer affects maintenance and progression , 2013, Oncogene.
[50] R. Aebersold,et al. Quantitative Analysis of Fission Yeast Transcriptomes and Proteomes in Proliferating and Quiescent Cells , 2012, Cell.
[51] D. Ruggero. Translational control in cancer etiology. , 2012, Cold Spring Harbor perspectives in biology.
[52] Masahiro Morita,et al. Distinct perturbation of the translatome by the antidiabetic drug metformin , 2012, Proceedings of the National Academy of Sciences.
[53] A. Pause,et al. An oxygen-regulated switch in the protein synthesis machinery , 2012, Nature.
[54] E. Marcotte,et al. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses , 2012, Nature Reviews Genetics.
[55] Nicholas T. Ingolia,et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis , 2012, Nature.
[56] Satoshi O. Suzuki,et al. Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors. , 2012, Cancer research.
[57] Feimeng Zheng,et al. Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells , 2011, Medical oncology.
[58] Nicholas T. Ingolia,et al. Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes , 2011, Cell.
[59] G. Ammerer,et al. Controlling gene expression in response to stress , 2011, Nature Reviews Genetics.
[60] M. Fishman,et al. A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer , 2011, Clinical Cancer Research.
[61] M. Selbach,et al. Global quantification of mammalian gene expression control , 2011, Nature.
[62] Stephan Frank,et al. MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. , 2011, Cancer research.
[63] M. Bushell,et al. Translational regulation of gene expression during conditions of cell stress. , 2010, Molecular cell.
[64] Jiangbin Ye,et al. The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation , 2010, The EMBO journal.
[65] Ya-Yun Cheng,et al. Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions , 2009, Nucleic acids research.
[66] N. Sonenberg,et al. p53-dependent translational control of senescence and transformation via 4E-BPs. , 2009, Cancer cell.
[67] C. Wagner,et al. Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. , 2009, ACS chemical biology.
[68] J. Deddens,et al. eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. , 2009, Cancer research.
[69] J. Aguirre-Ghiso,et al. Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. , 2009, Cancer research.
[70] S. Kimball,et al. ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. , 2009, Biochemical and biophysical research communications.
[71] P. Gao,et al. Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells , 2009, Breast Cancer Research and Treatment.
[72] H. Yee,et al. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. , 2007, Molecular cell.
[73] O. Larsson,et al. Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors. , 2007, Cancer research.
[74] N. Sonenberg,et al. Weak binding affinity of human 4EHP for mRNA cap analogs. , 2007, RNA.
[75] Dimitris Kletsas,et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints , 2006, Nature.
[76] Aaron Bensimon,et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication , 2006, Nature.
[77] Claes Wahlestedt,et al. Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure , 2006, Nucleic acids research.
[78] Robert J. Schneider,et al. Hypoxia Inhibits Protein Synthesis through a 4E-BP1 and Elongation Factor 2 Kinase Pathway Controlled by mTOR and Uncoupled in Breast Cancer Cells , 2006, Molecular and Cellular Biology.
[79] P. Lambin,et al. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control , 2006, The EMBO journal.
[80] N. Sonenberg,et al. Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[81] D. Ron,et al. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response , 2004, The Journal of cell biology.
[82] K. Bennewith,et al. Quantifying Transient Hypoxia in Human Tumor Xenografts by Flow Cytometry , 2004, Cancer Research.
[83] Amy R. Cameron,et al. Characterization of mammalian eIF4E-family members. , 2004, European journal of biochemistry.
[84] P. Pandolfi,et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis , 2004, Nature Medicine.
[85] M. Mathews,et al. Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR , 2002, Oncogene.
[86] A. Fraire,et al. Expression of eukaryotic translation initiation factors 4E and 2α is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung , 2001, Cancer.
[87] B. Woda,et al. Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas. , 1999, The American journal of pathology.
[88] A. Harris,et al. Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E. , 1998, British Journal of Cancer.
[89] Benjamin D. L. Li,et al. Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas , 1997, Oncogene.
[90] G. Brown,et al. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. , 1997, Physiological reviews.
[91] F. Buttgereit,et al. A hierarchy of ATP-consuming processes in mammalian cells. , 1995, The Biochemical journal.
[92] A. De Benedetti,et al. Decreasing the level of translation initiation factor 4E with antisense rna causes reversal of ras‐mediated transformation and tumorigenesis of cloned rat embryo fibroblasts , 1993, International journal of cancer.
[93] N. Sonenberg,et al. The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts , 1992, Molecular and cellular biology.
[94] N. Sonenberg,et al. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap , 1990, Nature.
[95] N. Sonenberg,et al. eIF4E and Its Binding Proteins , 2014 .
[96] A. De Benedetti,et al. eIF4E expression in tumors: its possible role in progression of malignancies. , 1999, The international journal of biochemistry & cell biology.