Translational control and the cancer cell response to stress.

[1]  I. Ulitsky,et al.  Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress , 2017, eLife.

[2]  Christos G. Gkogkas,et al.  Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2 , 2016, Proceedings of the National Academy of Sciences.

[3]  S. Steinberg,et al.  Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750—an antisense oligonucleotide against eIF4E—in combination with irinotecan in solid tumors and irinotecan‐refractory colorectal cancer , 2016, International journal of cancer.

[4]  Xuemei Jiang,et al.  Prognostic significance of eukaryotic initiation factor 4E in hepatocellular carcinoma , 2016, Journal of Cancer Research and Clinical Oncology.

[5]  J. Seebacher,et al.  Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy. , 2016, Cellular signalling.

[6]  A. Kinghorn,et al.  Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas. , 2016, Neuro-oncology.

[7]  M. Pospíšek,et al.  Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules , 2016, BMC Molecular Biology.

[8]  R. Young,et al.  The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs , 2016, Genes & development.

[9]  M. Haigis,et al.  Mitochondria and Cancer , 2016, Cell.

[10]  S. Ramón y. Cajal,et al.  peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas , 2016, Cancer medicine.

[11]  J. Doudna,et al.  eIF3d is an mRNA cap-binding protein required for specialized translation initiation , 2016, Nature.

[12]  R. E. Luna,et al.  Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation , 2016, Nucleic acids research.

[13]  A. Hinnebusch,et al.  Translational control by 5′-untranslated regions of eukaryotic mRNAs , 2016, Science.

[14]  Chuan-Yuan Li,et al.  eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation. , 2016, Cancer letters.

[15]  R. Schneider,et al.  Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer , 2016, Molecular Cancer Therapeutics.

[16]  Davide Ruggero,et al.  New frontiers in translational control of the cancer genome , 2016, Nature Reviews Cancer.

[17]  Masahiro Morita,et al.  mTORC1 and CK2 coordinate ternary and eIF4F complex assembly , 2016, Nature Communications.

[18]  J. Pelletier,et al.  nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs , 2016, Genome research.

[19]  J. Deddens,et al.  Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma , 2016, British Journal of Cancer.

[20]  Kyungho Lee,et al.  Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells , 2016, Molecules and cells.

[21]  A. Ballestrero,et al.  EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition , 2015, BMC Cancer.

[22]  B. Jasani,et al.  Phospho-4e-BP1 and eIF4E overexpression synergistically drives disease progression in clinically confined clear cell renal cell carcinoma. , 2015, American journal of cancer research.

[23]  T. Tokuyasu,et al.  Differential Requirements for eIF4E Dose in Normal Development and Cancer , 2015, Cell.

[24]  A. Koromilas Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment. , 2015, Biochimica et biophysica acta.

[25]  P. Sorensen,et al.  Stress-mediated translational control in cancer cells. , 2015, Biochimica et biophysica acta.

[26]  G. Thomas,et al.  A liaison between mTOR signaling, ribosome biogenesis and cancer. , 2015, Biochimica et biophysica acta.

[27]  Jiangbin Ye,et al.  Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress , 2015, PLoS genetics.

[28]  N. Sonenberg,et al.  Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches , 2015, PloS one.

[29]  Shuye Tian,et al.  The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding. , 2015, The Biochemical journal.

[30]  Eun Hee Lee,et al.  Prognostic significance of phosphorylated 4E-binding protein 1 in non-small cell lung cancer. , 2015, International journal of clinical and experimental pathology.

[31]  D. Speicher,et al.  Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts , 2015, Cell cycle.

[32]  W. Miller,et al.  Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis. , 2015, Cancer research.

[33]  N. Sonenberg,et al.  Targeting the translation machinery in cancer , 2015, Nature Reviews Drug Discovery.

[34]  D. Yee,et al.  eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells. , 2015, Cancer research.

[35]  D. Sabatini,et al.  Nutrient-sensing mechanisms and pathways , 2015, Nature.

[36]  S. Huang,et al.  Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress , 2015, Cell Death and Disease.

[37]  A. Eggermont,et al.  eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies , 2014, Nature.

[38]  N. Sonenberg,et al.  Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3 , 2014, Oncogene.

[39]  R. Xiang,et al.  Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. , 2014, Trends in biochemical sciences.

[40]  A. Tee,et al.  mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3 , 2014, Oncogene.

[41]  S. Kimball,et al.  Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1). , 2013, Cellular signalling.

[42]  R. Kaufman,et al.  eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies , 2013, Aging.

[43]  N. Sonenberg,et al.  mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. , 2013, Cell metabolism.

[44]  Benjamin J. Raphael,et al.  Mutational landscape and significance across 12 major cancer types , 2013, Nature.

[45]  B. Clarke,et al.  Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3 , 2013, Clinical Cancer Research.

[46]  Sofia Khan,et al.  Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment , 2013, Breast Cancer Research and Treatment.

[47]  S. Formenti,et al.  Vitronectin-αvβ3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells. , 2013, Cancer research.

[48]  E. Papadopoulos,et al.  Hypoxia-inducible Factor-1α (HIF-1α) Promotes Cap-dependent Translation of Selective mRNAs through Up-regulating Initiation Factor eIF4E1 in Breast Cancer Cells under Hypoxia Conditions* , 2013, The Journal of Biological Chemistry.

[49]  J. Pelletier,et al.  eIF4F suppression in breast cancer affects maintenance and progression , 2013, Oncogene.

[50]  R. Aebersold,et al.  Quantitative Analysis of Fission Yeast Transcriptomes and Proteomes in Proliferating and Quiescent Cells , 2012, Cell.

[51]  D. Ruggero Translational control in cancer etiology. , 2012, Cold Spring Harbor perspectives in biology.

[52]  Masahiro Morita,et al.  Distinct perturbation of the translatome by the antidiabetic drug metformin , 2012, Proceedings of the National Academy of Sciences.

[53]  A. Pause,et al.  An oxygen-regulated switch in the protein synthesis machinery , 2012, Nature.

[54]  E. Marcotte,et al.  Insights into the regulation of protein abundance from proteomic and transcriptomic analyses , 2012, Nature Reviews Genetics.

[55]  Nicholas T. Ingolia,et al.  The translational landscape of mTOR signalling steers cancer initiation and metastasis , 2012, Nature.

[56]  Satoshi O. Suzuki,et al.  Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors. , 2012, Cancer research.

[57]  Feimeng Zheng,et al.  Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells , 2011, Medical oncology.

[58]  Nicholas T. Ingolia,et al.  Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes , 2011, Cell.

[59]  G. Ammerer,et al.  Controlling gene expression in response to stress , 2011, Nature Reviews Genetics.

[60]  M. Fishman,et al.  A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer , 2011, Clinical Cancer Research.

[61]  M. Selbach,et al.  Global quantification of mammalian gene expression control , 2011, Nature.

[62]  Stephan Frank,et al.  MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. , 2011, Cancer research.

[63]  M. Bushell,et al.  Translational regulation of gene expression during conditions of cell stress. , 2010, Molecular cell.

[64]  Jiangbin Ye,et al.  The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation , 2010, The EMBO journal.

[65]  Ya-Yun Cheng,et al.  Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions , 2009, Nucleic acids research.

[66]  N. Sonenberg,et al.  p53-dependent translational control of senescence and transformation via 4E-BPs. , 2009, Cancer cell.

[67]  C. Wagner,et al.  Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. , 2009, ACS chemical biology.

[68]  J. Deddens,et al.  eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. , 2009, Cancer research.

[69]  J. Aguirre-Ghiso,et al.  Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. , 2009, Cancer research.

[70]  S. Kimball,et al.  ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. , 2009, Biochemical and biophysical research communications.

[71]  P. Gao,et al.  Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells , 2009, Breast Cancer Research and Treatment.

[72]  H. Yee,et al.  A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. , 2007, Molecular cell.

[73]  O. Larsson,et al.  Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors. , 2007, Cancer research.

[74]  N. Sonenberg,et al.  Weak binding affinity of human 4EHP for mRNA cap analogs. , 2007, RNA.

[75]  Dimitris Kletsas,et al.  Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints , 2006, Nature.

[76]  Aaron Bensimon,et al.  Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication , 2006, Nature.

[77]  Claes Wahlestedt,et al.  Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure , 2006, Nucleic acids research.

[78]  Robert J. Schneider,et al.  Hypoxia Inhibits Protein Synthesis through a 4E-BP1 and Elongation Factor 2 Kinase Pathway Controlled by mTOR and Uncoupled in Breast Cancer Cells , 2006, Molecular and Cellular Biology.

[79]  P. Lambin,et al.  Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control , 2006, The EMBO journal.

[80]  N. Sonenberg,et al.  Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[81]  D. Ron,et al.  Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response , 2004, The Journal of cell biology.

[82]  K. Bennewith,et al.  Quantifying Transient Hypoxia in Human Tumor Xenografts by Flow Cytometry , 2004, Cancer Research.

[83]  Amy R. Cameron,et al.  Characterization of mammalian eIF4E-family members. , 2004, European journal of biochemistry.

[84]  P. Pandolfi,et al.  The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis , 2004, Nature Medicine.

[85]  M. Mathews,et al.  Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR , 2002, Oncogene.

[86]  A. Fraire,et al.  Expression of eukaryotic translation initiation factors 4E and 2α is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung , 2001, Cancer.

[87]  B. Woda,et al.  Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas. , 1999, The American journal of pathology.

[88]  A. Harris,et al.  Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E. , 1998, British Journal of Cancer.

[89]  Benjamin D. L. Li,et al.  Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas , 1997, Oncogene.

[90]  G. Brown,et al.  Cellular energy utilization and molecular origin of standard metabolic rate in mammals. , 1997, Physiological reviews.

[91]  F. Buttgereit,et al.  A hierarchy of ATP-consuming processes in mammalian cells. , 1995, The Biochemical journal.

[92]  A. De Benedetti,et al.  Decreasing the level of translation initiation factor 4E with antisense rna causes reversal of ras‐mediated transformation and tumorigenesis of cloned rat embryo fibroblasts , 1993, International journal of cancer.

[93]  N. Sonenberg,et al.  The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts , 1992, Molecular and cellular biology.

[94]  N. Sonenberg,et al.  Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap , 1990, Nature.

[95]  N. Sonenberg,et al.  eIF4E and Its Binding Proteins , 2014 .

[96]  A. De Benedetti,et al.  eIF4E expression in tumors: its possible role in progression of malignancies. , 1999, The international journal of biochemistry & cell biology.